Meclofenamic Acid (Meclofenamate)

A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.

Also Known As:

Meclofenamate; Meclofenamate Sodium; Benzoic acid, 2-((2,6-dichloro-3-methylphenyl)amino)-, monosodium salt, monohydrate; Meclofenamate Sodium Anhydrous; Meclofenamate Sodium Monohydrate; Meclomen; Sodium Meclofenamate; Meclofenamate, Sodium; Benzoic acid, 2-((2,6-dichloro-3-methylphenyl)amino)-

Networked: 221 relevant articles (26 outcomes, 34 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzoates: 426
        Aminobenzoates: 1
        ortho-Aminobenzoates: 8
        Fenamates: 20
        Meclofenamic Acid: 221
        terofenamate: 1
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Benzoates: 426
      - Aminobenzoates: 1
        ortho-Aminobenzoates: 8
        Fenamates: 20
        Meclofenamic Acid: 221
        terofenamate: 1

Experts

1.	Diéguez, Godofredo: 7 articles (02/2008 - 12/2002)
2.	Fernández, Nuria: 7 articles (02/2008 - 12/2002)
3.	Monge, Luis: 7 articles (02/2008 - 12/2002)
4.	Guzman-Esquivel, Jose: 4 articles (10/2015 - 04/2012)
5.	García-Villalón, Angel Luis: 4 articles (02/2008 - 05/2004)
6.	Delgado-Enciso, Ivan: 3 articles (10/2015 - 04/2012)
7.	Espinoza-Gómez, Francisco: 3 articles (10/2015 - 04/2012)
8.	Galvan-Salazar, Hector R: 3 articles (10/2015 - 04/2012)
9.	Montes-Galindo, Daniel A: 3 articles (10/2015 - 04/2012)
10.	Valdez-Velazquez, Laura L: 3 articles (10/2015 - 04/2012)

Related Diseases

1.	Pain (Aches) 01/01/1983 - "Analysis of variance of the data from those patients who completed 12 weeks in the trial showed that in the sodium meclofenamate group there was a significant improvement in articular index, left grip strength, pain severity and patients' global assessment over the course of the study. " 05/01/1985 - "When compared with the placebo, meclofenamate sodium at either dose level produced a significantly greater reduction in pain intensity, greater pain relief, fewer withdrawals for inefficacy, greater percentage of patients who considered their medication effective, and greater percentage of patients considered by the investigator to have received drug-attributable benefits. " 02/01/1993 - "Similarly, after 4 and 8 days, both types of pain improved to a larger extent in the meclofenamic acid group with respect to the naproxene group (P < 0.05 after four days and P < 0.01 after eight days). " 01/01/1981 - "Morning stiffness, walking speed, pain score, patient impression of response, joint tenderness and power, work and maximum grip strength achieved by hand grip were all improved by sodium meclofenamate and an anti-inflammatory effect of the drug was demonstrated, with some reduction in the swelling of PIP joints. " 01/01/2021 - "Meclofenamate is a nonsteroidal anti-inflammatory drug used in the treatment of mild-to-moderate pain yet poses a rare risk of hepatotoxicity through an unknown mechanism. "
2.	Rheumatoid Arthritis 01/01/1983 - "Meclofenamate sodium is a safe, effective agent for the treatment of rheumatoid arthritis." 01/01/1981 - "A single-blind crossover trial was carried out in 21 patients with active rheumatoid arthritis to assess the effectiveness and tolerance of sodium meclofenamate (300 mg per day) compared with placebo. " 01/01/1988 - "Plasma and synovial fluid meclofenamic acid concentrations in patients with rheumatoid arthritis of the knee." 01/01/1983 - "Double-blind multicenter studies with meclofenamate sodium in the treatment of rheumatoid arthritis in the United States and Canada." 01/01/1981 - "Sodium meclofenamate showed good control of disease activity and was generally well tolerated in the treatment of rheumatoid arthritis."
3.	Prostatic Neoplasms (Prostate Cancer) 04/01/2012 - "In vivo trials were divided into two phases; meclofenamic acid toxicity was initially determined at different doses (0, 5, 10 and 20 mg/kg/day/25 days) in BALB/c mice, after which a trial using non-toxic doses was carried out to evaluate the antitumor efficacy of the drug in a PC3/nude-mouse model of human androgen-independent prostate cancer. " 03/01/2018 - "The cytotoxicity of simvastatin and meclofenamic acid was assessed in prostate cancer cells using MTS and migration assays. " 03/01/2018 - "Simvastatin in combination with meclofenamic acid inhibits the proliferation and migration of human prostate cancer PC-3 cells via an AKR1C3 mechanism." 09/01/2015 - "The objective of the present work was to analyze the histological changes caused by meclofenamic acid in androgen-independent prostate cancer. " 04/01/2012 - "Antitumor effect of meclofenamic acid on human androgen-independent prostate cancer: a preclinical evaluation."
4.	Postoperative Pain 03/01/1992 - "Effects of sodium meclofenamate on postoperative pain following periodontal surgery." 01/01/1991 - "A brief review of meclofenamic acid use for primary dysmenorrhea, menorrhagia, and episiotomy pain is followed by an original study of this compound in postsurgical pain and stress. " 07/01/1985 - "The efficacy of meclofenamate sodium (Meclomen) at two different doses was compared with that of buffered aspirin and placebo in the control of postsurgical pain in a double-blind, randomized study of 205 patients. " 03/01/1992 - "It is concluded that meclofenamate is a non-steroidal antiinflammatory drug with interesting analgesic properties which can be used as directed as an alternative to aspirin or acetaminophen for the control of postoperative pain following periodontal surgery."
5.	Menorrhagia 10/01/1987 - "A double-blind, placebo-controlled crossover trial was undertaken to determine the efficacy of meclofenamate sodium in the treatment of menorrhagia. " 10/01/1987 - "Treatment of menorrhagia with meclofenamate sodium." 01/01/1991 - "A brief review of meclofenamic acid use for primary dysmenorrhea, menorrhagia, and episiotomy pain is followed by an original study of this compound in postsurgical pain and stress. " 01/01/1991 - "Meclofenamic acid is a nonsteroidal anti-inflammatory drug (NSAID) approved for use in arthritis (osteo and rheumatoid), analgesia (mild to moderate pain), dysmenorrhea, and heavy menstrual blood loss (menorrhagia). "

Related Drugs and Biologics

1.	Meclofenamic Acid (Meclofenamate)
2.	Indomethacin (Indometacin)
3.	Analgesics (Analgesic Drugs)
4.	Aspirin (Acetylsalicylic Acid)
5.	Ibuprofen (Motrin)
6.	Sodium
7.	Naproxen (Naprosyn)
8.	Codeine (Codeine Phosphate)
9.	Androgens
10.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)

Related Therapies and Procedures

1.	Episiotomy
2.	Therapeutics
3.	Root Planing
4.	Ligation
5.	Oral Surgery (Maxillofacial Surgery)