2-Methyl-4-chlorophenoxyacetic Acid (MCPA)

03/02/2016 - "A Community-Engaged Approach to Developing a Mobile Cancer Prevention App: The mCPA Study Protocol."
01/01/2013 - "This systematic review assembles the available data to evaluate epidemiologic, toxicological, pharmacokinetic, exposure, and biomonitoring studies with respect to key cellular events noted in disease etiology and how those relate to hypothesized modes of action for these constituents to determine the plausibility of an association between exposure to environmentally relevant concentrations of 2,4-D and MCPA and lymphohematopoietic cancers. "
03/02/2016 - "A community academic team will develop a theory-based, culturally tailored, mobile-enabled, Web-based app-the Mobile Cancer Prevention App (mCPA)-to promote adherence to dietary and physical activity guidelines. "
01/01/2016 - "Treatment with DPX/mCPA could delay tumor growth, and tri-therapy with DPX/mCPA/anti-PD-1 provided long-term control of tumors. "
01/01/2016 - "We found that treatment with DPX/mCPA/anti-PD-1 enhanced systemic antigen-specific immune responses detected in the spleen as determined by IFN-γ ELISpot compared to those in the DPX/mCPA group, but immune responses in tumor-draining lymph nodes were not increased. "

10/01/1986 - "Among workers whose jobs entailed potential exposure to MCPA, there was one death from soft tissue sarcoma (0.6 expected). "
04/01/1998 - "Based on small numbers, the study suggests an association between the exposure to MCPA and related phenoxy herbicides and the risk of soft-tissue sarcoma. "
01/01/2013 - "Epidemiologic studies suggest that exposure to 2,4-D and MCPA may be associated with increased risk non-Hodgkins lymphoma (NHL), Hodgkin's disease (HD), leukemia, and soft-tissue sarcoma (STS). "
10/01/1986 - "The findings do not exclude the possibility that MCPA is a human carcinogen, but they suggest that any risk of soft tissue sarcoma is less than that indicated by earlier studies of 2,4,5-T (2,4,5-trichlorophenoxyacetic acid) and 2,4,5-trichlorophenol and is small in absolute terms."

03/02/2016 - "The aim of this study is to develop mCPA content with input from breast cancer survivors. "
05/02/2019 - "To analyze the potential effects that selected herbicides (MCPA, mesotrione, bifenox and dichlobenil) may have upon cancerous cells, we conducted studies of the cytotoxicity of physiological concentrations of four pesticides and the mix of TA with tested herbicides in three different breast cancer cell lines (MCF-7, ZR-75-1 and MDA-MB-231) and one normal healthy breast cell line MCF-12A. "

12/19/2022 - "The objective of this study is to describe the epidemiology, case fatality and extent of renal injury in a large cohort of MCPA self-poisonings. "
04/01/2023 - "To our knowledge, liver damage is a rare manifestation of MCPA poisoning, which has not yet been reported in Sri Lanka. "
12/19/2022 - "The higher numbers of men with MCPA poisoning likely reflects greater occupational access to pesticides. "
03/25/2011 - "128 blood samples were obtained in 49 patients with acute MCPA poisoning and total and unbound concentrations of MCPA were determined. "
03/01/2008 - "From these toxicological data, together with autopsy findings, the cause of his death was diagnosed as acute MCPA poisoning."

01/01/1975 - "In subacute dermal studies in rabbits during 3 weeks the dosages were 0, 0.5, 1.0 and 2 g MCPA or MCPP per kg body weight. "
06/01/2005 - "MCPA at 2000 ppm caused reduced food consumption and body weight gain and increased water consumption in females only. "
08/01/1989 - "administration of MCPA, virtually no distribution occurs (Vrel = 18% of the body weight). "
12/01/1983 - "Five healthy volunteers were given 15 micrograms MCPA per kg body weight. "
07/15/2004 - "For both 2,4-D and MCPA, the dog plasma half-life (t(1/2)) and renal clearance (Clr; mL/h) rates did not scale as a function of body weight across species; whereas for all other species evaluated, including humans, these pharmacokinetic parameters reasonably scaled. "