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Marfan Syndrome (Marfan's Syndrome)

An autosomal dominant disorder of CONNECTIVE TISSUE with abnormal features in the heart, the eye, and the skeleton. Cardiovascular manifestations include MITRAL VALVE PROLAPSE, dilation of the AORTA, and aortic dissection. Other features include lens displacement (ectopia lentis), disproportioned long limbs and enlarged DURA MATER (dural ectasia). Marfan syndrome is associated with mutations in the gene encoding fibrillin, a major element of extracellular microfibrils of connective tissue.
Also Known As:
Marfan's Syndrome; Marfans Syndrome; Syndrome, Marfan; Syndrome, Marfan's
Networked: 1272 relevant articles (20 outcomes, 88 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Aortic Aneurysm (Aneurysm, Aortic)
2. Aneurysm (Aneurysms)
3. Ectopia Lentis
4. Thoracic Aortic Aneurysm
5. Hypertension (High Blood Pressure)

Experts

1. Dietz, Harry C: 34 articles (05/2015 - 04/2002)
2. Ramirez, Francesco: 20 articles (11/2015 - 03/2003)
3. Reinhardt, Dieter P: 16 articles (07/2015 - 12/2002)
4. Milewicz, Dianna M: 14 articles (01/2014 - 01/2002)
5. Boileau, Catherine: 13 articles (08/2015 - 04/2002)
6. Robinson, Peter N: 13 articles (11/2014 - 09/2002)
7. Judge, Daniel P: 11 articles (01/2015 - 07/2004)
8. Groenink, Maarten: 10 articles (05/2015 - 07/2002)
9. Mulder, Barbara J M: 10 articles (04/2015 - 07/2002)
10. Hubmacher, Dirk: 9 articles (05/2015 - 10/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Marfan Syndrome:
1. Losartan (Cozaar)FDA LinkGeneric
2. fibrillinIBA
3. Atenolol (Tenormin)FDA LinkGeneric
4. AngiotensinsIBA
5. Transforming Growth Factor beta (TGF-beta)IBA
6. DNA (Deoxyribonucleic Acid)IBA
7. Angiotensin IIIBA
8. Doxycycline (Vibramycin)FDA LinkGeneric
9. Angiotensin IIBA
10. Angiotensin Receptors (Angiotensin II Receptor)IBA

Therapies and Procedures

1. Transplants (Transplant)
2. Prostheses and Implants (Prosthesis)
3. Palatal Expansion Technique
4. Mandibular Advancement
5. Lenses