Mannosyltransferases

Enzymes that catalyze the transfer of mannose from a nucleoside diphosphate mannose to an acceptor molecule which is frequently another carbohydrate. The group includes EC 2.4.1.32, EC 2.4.1.48, EC 2.4.1.54, and EC 2.4.1.57.

Also Known As:

Networked: 52 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Thiel, Christian: 6 articles (01/2022 - 10/2002)
2.	Lehle, Ludwig: 6 articles (10/2012 - 10/2002)
3.	Denecke, Jonas: 4 articles (01/2019 - 03/2004)
4.	Körner, Christian: 4 articles (04/2010 - 10/2002)
5.	Kranz, Christian: 3 articles (08/2005 - 03/2004)
6.	Marquardt, Thorsten: 3 articles (08/2005 - 03/2004)
7.	Schwarz, Markus: 3 articles (03/2004 - 10/2002)
8.	von Figura, Kurt: 3 articles (03/2004 - 10/2002)
9.	Dimitrov, Bianca: 2 articles (01/2022 - 01/2019)
10.	Himmelreich, Nastassja: 2 articles (01/2022 - 01/2019)

Related Diseases

1.	Congenital, Hereditary, and Neonatal Diseases and Abnormalities (Congenital Disorders) 01/01/2019 - "ALG3-CDG is one of the very rare types of congenital disorder of glycosylation (CDG) caused by variants in the ER-mannosyltransferase ALG3. " 10/01/2012 - "Deficiency of β-1,4 mannosyltransferase (MT-1) congenital disorder of glycosylation (CDG), due to ALG1 gene mutations. " 09/15/2002 - "The ALG12 mannosyltransferase defect defines a new type of congenital disorder of glycosylation, designated CDG-Ig." 09/15/2002 - "ALG12 mannosyltransferase defect in congenital disorder of glycosylation type lg." 04/15/2010 - "A severe human metabolic disease caused by deficiency of the endoplasmatic mannosyltransferase hALG11 leads to congenital disorder of glycosylation-Ip."
2.	Muscular Dystrophies (Muscular Dystrophy) 01/01/2018 - "This mechanism may shed light on analogous functions of POMT genes in mammals and help to elucidate the etiology of neurological defects in muscular dystrophies.SIGNIFICANCE STATEMENT Protein O-mannosyltransferases (POMTs) are evolutionarily conserved in metazoans. " 01/01/2023 - "Mutations in protein O-mannosyltransferases (POMTs) result in severe brain defects and congenital muscular dystrophies characterized by abnormal glycosylation of α-dystroglycan (α-Dg). " 01/12/2010 - "Mutations in protein O-mannosyltransferases (POMTs) cause a heterogeneous group of muscular dystrophies with abnormal glycosylation of alpha-dystroglycan (dystroglycanopathies). " 04/05/2013 - "During the last years, a few mammalian proteins have been identified as targets of the protein-O-mannosyltransferases 1 and 2. However, these still cannot explain the high content of O-mannosyl glycans in brain and the strong brain involvement of congenital muscular dystrophies caused by POMT mutations (Walker-Warburg syndrome, dystroglycanopathies). " 01/13/2004 - "Among these muscular dystrophies, Walker-Warburg syndrome is caused by mutations in the gene encoding putative protein O-mannosyltransferase 1 (POMT1), which is homologous to yeast protein O-mannosyltransferases. "
3.	Congenital Disorders of Glycosylation 07/12/2002 - "Congenital disorders of glycosylation type Ig is defined by a deficiency in dolichyl-P-mannose:Man7GlcNAc2-PP-dolichyl mannosyltransferase." 12/01/1999 - "Carbohydrate deficient glycoprotein syndrome type IV: deficiency of dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase." 11/01/2010 - "Guanosine diphosphate-mannose:GlcNAc2-PP-dolichol mannosyltransferase deficiency (congenital disorders of glycosylation type Ik): five new patients and seven novel mutations." 04/15/2010 - "A new type of congenital disorders of glycosylation, designated CDG-Ip, is caused by the deficiency of GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase, encoded by the human ortholog of ALG11 from yeast. " 06/20/2003 - "Deficiency of GDP-Man:Man1GlcNAc2-PP-dolichol mannosyltransferase (hALG2), is the cause of a new type of congenital disorders of glycosylation (CDG) designated CDG-Ii. The patient presented normal at birth but developed in the 1st year of life a multisystemic disorder with mental retardation, seizures, coloboma of the iris, hypomyelination, hepatomegaly, and coagulation abnormalities. "
4.	Walker-Warburg Syndrome 11/01/2002 - "Mutations in the O-mannosyltransferase gene POMT1 give rise to the severe neuronal migration disorder Walker-Warburg syndrome." 08/01/2008 - "POMT2, a key enzyme in Walker-Warburg syndrome: somatic sPOMT2, but not testis-specific tPOMT2, is crucial for mannosyltransferase activity in vivo." 04/05/2013 - "During the last years, a few mammalian proteins have been identified as targets of the protein-O-mannosyltransferases 1 and 2. However, these still cannot explain the high content of O-mannosyl glycans in brain and the strong brain involvement of congenital muscular dystrophies caused by POMT mutations (Walker-Warburg syndrome, dystroglycanopathies). " 01/13/2004 - "Among these muscular dystrophies, Walker-Warburg syndrome is caused by mutations in the gene encoding putative protein O-mannosyltransferase 1 (POMT1), which is homologous to yeast protein O-mannosyltransferases. "
5.	Tuberculosis (Tuberculoses) 02/25/2004 - "Mannosyltransferases play a crucial role in mycobacterial cell-wall biosynthesis and are potential new drug targets for the treatment of tuberculosis. " 03/14/2008 - "tuberculosis and NCgl2106 in Corynebacterium glutamicum) that encodes a mannosyltransferase involved in the synthesis of the early dimannosylated PIM species, acyl-PIM2, and LAM. " 08/05/2005 - "tuberculosis membrane protein homolog of eukaryotic protein mannosyltransferases, was shown to catalyze the initial step of protein mannosylation. " 09/12/2006 - "tuberculosis, with 10 predicted transmembrane domains and a glycosyltransferase (GT) motif (DID), features that are common to eukaryotic mannosyltransferases (ManTs) of the GT-C superfamily that rely on polyprenyl-linked rather than nucleotide-linked sugar donors. "

Related Drugs and Biologics

1.	Dolichols
2.	Enzymes
3.	Polysaccharides (Glycans)
4.	chitobiose
5.	Proteins (Proteins, Gene)
6.	Mannose (D-Mannose)
7.	N,N-diacetylchitobiose
8.	Dystroglycans (Dystroglycan)
9.	Guanosine Diphosphate (GDP)
10.	dolichol monophosphate (dolichyl phosphate)