|1.||Liu, Bo: 8 articles (10/2014 - 10/2008)|
|2.||Bao, Jin-Ku: 7 articles (04/2013 - 02/2006)|
|3.||Balzarini, Jan: 7 articles (09/2012 - 10/2004)|
|4.||Morère, Alain: 6 articles (05/2015 - 05/2006)|
|5.||Garcia, Marcel: 6 articles (05/2015 - 05/2006)|
|6.||Braulke, Thomas: 6 articles (10/2014 - 09/2005)|
|7.||Freeze, Hudson H: 6 articles (04/2014 - 03/2006)|
|8.||Gary-Bobo, Magali: 5 articles (05/2015 - 03/2009)|
|9.||Maillard, Philippe: 5 articles (05/2015 - 03/2009)|
|10.||Durand, Jean-Olivier: 5 articles (05/2015 - 03/2009)|
|1.||Gaucher Disease (Gaucher's Disease)
01/01/1994 - "Two pediatric female patients with moderately severe type 1 Gaucher disease were treated with commercially available GC, mannose terminated to be macrophage-targeted. "
02/01/1995 - "Mannose-terminal glucocerebrosidase prepared by exoglycosidase digestion of human placental glucocerebrosidase is reported effective in the treatment of patients with type 1 Gaucher's disease [Barton et al. (1991); N Engl J Med 324:1464-1470]. "
10/01/1991 - "We describe here an investigation of the hematologic response of a child with Gaucher disease to a six-year therapeutic trial of human placental mannose-terminated glucocerebrosidase. "
10/10/2006 - "Except for Gaucher disease, for which an enzyme with exposed mannosyl residues targets mannose receptors (MR) on macrophages, ERT targets primarily the mannose 6-phosphate receptor (MPR). "
04/01/2002 - "In anticipation of intracerebral administration of mannose-terminal glucocerebrosidase to patients with type 2 Gaucher disease, it was important to learn the mechanism involved in its cellular uptake. "
11/01/2011 - "Biodistribution studies were carried out in athymic mice with induced tumours (PC-3 or C6 cancer cells) or in Wistar rats (⁹⁹mTc-AuNP-mannose for sentinel lymph node detection). "
09/01/2015 - "γ-Tilmanocept ((99m)Tc-labeled-tilmanocept or [(99m)Tc]-tilmanocept) is the first mannose-containing, receptor-directed, radiolabeled tracer for the highly sensitive imaging of sentinel lymph nodes in solid tumor staging. "
01/01/2015 - " The recently discovered high mannose (HM)-binding lectin family in lower organisms such as bacteria, cyanobacteria, and marine algae represents a novel class of anti-viral or anti-tumor compounds. "
12/01/2014 - "We also confirmed that the acid-sensitive sheddable PEGylated, mannose-modified DOX-nanoparticles (DOX-AS-M-NPs) targeted TAMs because depletion of TAMs in tumor-bearing mice significantly decreased the accumulation of DOX in tumor tissues. "
12/01/2014 - "We demonstrated that surface-modification of the DOX-NPs with both mannose and acid-sensitive sheddable PEG significantly increased the accumulation of DOX in tumors, enhanced the uptake of the DOX by TAMs, but decreased the distribution of DOX in mononuclear phagocyte system (MPS), such as liver. "
|3.||Urinary Tract Infections (Urinary Tract Infection)
02/01/2014 - "To test whether D-mannose powder is effective for recurrent urinary tract infection (UTI) prevention. "
01/01/1985 - "Earlier studies have shown that the majority of Escherichia coli isolates from urinary tract infections which possess a D-mannose-resistant adhesin contain gene sequences homologous to the pap pilus gene sequences encoded on the recombinant plasmid pRHU845. "
02/01/2014 - "D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial."
01/01/2014 - "Use of D-mannose in prophylaxis of recurrent urinary tract infections (UTIs) in women."
12/29/2009 - "Positive selection identifies an in vivo role for FimH during urinary tract infection in addition to mannose binding."
10/15/2009 - "A polarizable molecular mechanics (SIBFA) study was performed on the complexes of d-mannose 6-phosphate and two of its analogues with PMI from Candida albicans, an enzyme involved in yeast infection homologous to S. "
12/01/1992 - "However, a temporal study up to 14 days post-infection indicates that, as it matures, the vacuole gains mannose 6-phosphate receptor, and becomes more accessible to endocytosed ligand, suggesting that the vacuole has functionally translocated from a lysosomal to late endosomal compartment. "
11/01/2015 - "Furthermore, E. tarda infection was significantly inhibited by mannose pretreatment suggesting that the bacterium potentially recognizes and binds to mannose or mannose containing chains following desialylation. "
01/01/2015 - "These fibres recognize oligo-mannose units on the bacterial cell surface prior to infection and are composed of homotrimers of the pb1 protein. "
11/28/2011 - "Moreover, addition of mannose to an IBV vaccine altered both vaccine-induced changes in circulating T-cell populations and IBV specific vaccine and infection-induced antibody responses in chickens with high serum MBL levels. "
|5.||Breast Neoplasms (Breast Cancer)
05/20/2010 - "In conclusion, this study showed that the involvement of the mannose-mediated EGFR pathway has a critical function in the preclinical rationale for the development of PA-MSHA for the treatment of human breast cancer. "
05/20/2010 - "Inhibition of EGFR pathway signaling and the metastatic potential of breast cancer cells by PA-MSHA mediated by type 1 fimbriae via a mannose-dependent manner."
03/28/2009 - "Functionalisation of MSN with mannose for PDT applications dramatically improved the efficiency of PDT on breast cancer cells."
12/01/2013 - "Although loss of the mannose 6-phosphate/insulin-like growth factor-II receptor (M6P/IGF-IIR) in breast cancer is believed to play a role in tumorigenesis, it has not been demonstrated that M6P/IGF-IIR loss is sufficient to confer a malignant phenotype in an untransformed cell. "
01/01/2013 - "The results showed that, compared with the matched adjacent normal tissue samples, two biantennary N-glycans (NA2 and NA2FB) were significantly decreased (p <0.0001) in the breast cancer tissue samples, while the triantennary glycan (NA3FB) and a high-mannose glycan (M8) were dramatically increased (p = 0.001 and p <0.0001, respectively). "
|1.||Enzyme Replacement Therapy
|3.||Drug Therapy (Chemotherapy)