Mannose (D-Mannose)

A hexose or fermentable monosaccharide and isomer of glucose from manna, the ash Fraxinus ornus and related plants. (From Grant & Hackh's Chemical Dictionary, 5th ed & Random House Unabridged Dictionary, 2d ed)

Also Known As:

Networked: 1927 relevant articles (80 outcomes, 155 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Morère, Alain: 13 articles (07/2020 - 05/2006)
2.	Garcia, Marcel: 12 articles (07/2020 - 05/2006)
3.	Gary-Bobo, Magali: 12 articles (07/2020 - 03/2009)
4.	Freeze, Hudson H: 11 articles (01/2021 - 03/2006)
5.	Durand, Jean-Olivier: 9 articles (07/2020 - 03/2009)
6.	Braulke, Thomas: 9 articles (01/2020 - 09/2005)
7.	Maynadier, Marie: 9 articles (06/2019 - 12/2010)
8.	Wuhrer, Manfred: 8 articles (03/2022 - 01/2005)
9.	El Cheikh, Khaled: 8 articles (07/2020 - 12/2014)
10.	Liu, Bo: 8 articles (10/2014 - 10/2008)

Related Diseases

1.	Neoplasms (Cancer) 05/23/2023 - "Incubating type 1 pili expressing bacteria with the competitive FimH inhibitor D-mannose before cancer cell treatment also led to a significant reduction in cytotoxicity on both MDA-MB-231 and MCF-7 cancer cells, compared to vehicle control or D-mannose alone, indicating the requirement for functional FimH for cytotoxicity. " 10/17/2016 - "Targeting by multivalent mannose significantly improved the capability of DOX-loaded nanoparticles to inhibit the growth of MDA-MB-231 cancer cells with minimal side effects in vivo. " 11/01/2011 - "Biodistribution studies were carried out in athymic mice with induced tumours (PC-3 or C6 cancer cells) or in Wistar rats (⁹⁹mTc-AuNP-mannose for sentinel lymph node detection). " 08/30/2023 - "This review discusses the progress made in understanding the regulatory roles of mannose in cancer progression, the mechanisms underlying its anticancer effects, and its current application in cancer diagnosis and treatment." 08/30/2023 - "Biological function, regulatory mechanism, and clinical application of mannose in cancer."
2.	Gaucher Disease (Gaucher's Disease) 01/01/1994 - "Two pediatric female patients with moderately severe type 1 Gaucher disease were treated with commercially available GC, mannose terminated to be macrophage-targeted. " 01/01/2016 - "The recombinant GC, which has been used for enzyme replacement therapy in patients with Gaucher's disease, requires terminal mannose for its therapeutic efficacy. " 10/01/1991 - "We describe here an investigation of the hematologic response of a child with Gaucher disease to a six-year therapeutic trial of human placental mannose-terminated glucocerebrosidase. " 04/01/2002 - "In anticipation of intracerebral administration of mannose-terminal glucocerebrosidase to patients with type 2 Gaucher disease, it was important to learn the mechanism involved in its cellular uptake. " 11/18/2005 - "Enzyme replacement therapy (ERT) for Gaucher disease designed to target glucocerebrosidase (GC) to macrophages via mannose-specific endocytosis is very effective in reversing hepatosplenomegaly, and normalizing hematologic parameters but is less effective in improving bone and lung involvement and ineffective in brain. "
3.	Urinary Tract Infections (Urinary Tract Infection) 01/01/2016 - "The present study aimed to determine whether D-mannose alone is effective in treating acute urinary tract infections in women and its possible utility in the management of recurrences. " 02/01/2021 - "Efficacy of an orally administered combination of Lactobacillus paracasei LC11, cranberry and D-mannose for the prevention of uncomplicated, recurrent urinary tract infections in women." 01/01/2021 - "D-MannosE to prevent Recurrent urinary tract InfecTions (MERIT): protocol for a randomised controlled trial." 10/01/2020 - "There are few studies on the effect of combination of cranberry extract with D-mannose in acute urinary tract infection management. " 09/01/2020 - "In addition, we discussed the results of basic and clinical studies, proving the efficiency of D-mannose for prevention and treatment of lower urinary tract infection."
4.	Infections 07/31/2023 - "We observed that a macrophage membrane coating facilitated NP enrichment at the infection site, followed by active NP accumulation in macrophages in a mannose-dependent manner. " 05/01/2023 - "The above results demonstrated that mannose could be considered as a novel adjuvant therapeutic agent for anti-Trichinella drugs to block larval invasion at early stage of Trichinella infection." 05/01/2023 - "The protective effect of the mannose against Trichinella infection might be not related to specific antibody and cellular immune responses. " 11/01/2022 - "Pharmacodynamics of D-mannose in the prevention of recurrent urinary infections." 02/01/2022 - "Importance of mannose-binding lectin2 polymorphism (rs1800450) in infections in children."
5.	Cystitis 08/01/2022 - "Despite the limitations of the studies, the consistent results observed among all studies give support to the general findings that D-mannose may be useful in the treatment of UTI/cystitis symptoms." 08/01/2022 - "Studies were selected for the systematic review if they were clinical studies and reported original data, the number of patients using D-mannose alone or in association with other treatments, and the number of patients with symptoms of UTI/cystitis at trial entry and after the follow-up period. " 02/25/2022 - "A recent prospective, non-interventional study in female patients with acute cystitis reported good success rates for treatment with d-mannose. " 01/01/2016 - "The results of this study suggest that D-mannose can be an effective aid in acute cystitis management and also a successful prophylactic agent in a selected population; however, more studies will certainly be needed to confirm the results of our pilot study." 08/01/2022 - "In this paper, we systematically reviewed the published data on the effect of D-mannose, alone or in association with other compounds, on the typical symptoms of UTI/cystitis. "

Related Drugs and Biologics

1.	Glucosylceramidase (Glucocerebrosidase)
2.	Hemagglutinins (Hemagglutinin)
3.	Glucose (Dextrose)
4.	Antibodies
5.	Chitosan
6.	imiglucerase
7.	Polysaccharides (Glycans)
8.	Galactose (Galactopyranose)
9.	Enzymes
10.	Fructose

Related Therapies and Procedures

1.	Therapeutics
2.	Enzyme Replacement Therapy
3.	Drug Therapy (Chemotherapy)
4.	Immunotherapy
5.	Photochemotherapy (Photodynamic Therapy)