|1.||Kamiński, Krzysztof: 3 articles (02/2015 - 06/2010)|
|2.||Obniska, Jolanta: 3 articles (02/2015 - 06/2010)|
|3.||Chlebek, Iwona: 2 articles (09/2012 - 06/2010)|
|4.||Balzarini, J: 2 articles (11/2000 - 10/2000)|
|5.||Kowalchuk, T P: 2 articles (11/2000 - 10/2000)|
|6.||Nazarali, A J: 2 articles (11/2000 - 10/2000)|
|7.||Dimmock, J R: 2 articles (11/2000 - 10/2000)|
|8.||Allen, T M: 2 articles (11/2000 - 10/2000)|
|9.||Motaganahalli, N L: 2 articles (11/2000 - 10/2000)|
|10.||Kutty, Samuel K: 1 article (11/2015)|
11/15/2015 - "Synthesis, biological evaluation and structure-activity relationship studies of isoflavene based Mannich bases with potent anti-cancer activity."
07/15/2015 - "The synthesized Mannich bases were screened for in vitro growth inhibition against a panel of 3 different human cancer cell lines. "
08/01/1979 - "Five of the Mannich bases were evaluated as respiratory inhibitors in mitochondria derived from hepatic tumors, liver tissue from tumor-bearing animals, and normal rat liver. "
04/01/1972 - "[Antimicrobial and tumor-inhibiting effects of Mannich bases of the 3,3'-and 4,4'-dihydroxy- , -diethylstilben]."
11/01/2007 - "Ten of the Mannich bases characterized by significant activity in BV-173 were further evaluated against the chronic myeloid leukemia cell line K-562 and were found to suppress the growth of these cells at relatively higher concentrations as compared to the former tumor model. "
07/01/1981 - "The Mannich bases II, III and V raised the minimal electro-shock seizure threshold of rats. "
09/01/2012 - "A library of 21 new N-Mannich bases of 3,3-diphenyl- (5a-g), 3-methyl-3-phenyl- (6a-g), and 3-ethyl-3-methylpyrrolidine-2,5-diones (7a-g) were synthesized and evaluated for their anticonvulsant activity in the maximum electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) seizure tests after intraperitoneal injection into mice. "
06/01/2010 - "A series of new Mannich bases of N-[(4-arylpiperazin-1-yl)-methyl]-3-(chlorophenyl)-pyrrolidine-2,5-diones 10-23 have been synthesized and evaluated for their anticonvulsant activity in maximum electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) seizure threshold tests. "
08/01/2002 - "In the present study, anticonvulsant activity of hydrazones, Schiff and Mannich bases of isatin were evaluated by maximal electroshock method (MES) and metrazol-induced convulsions (MET) at 30, 100 and 300 mg/kg dose levels. "
04/01/1984 - "Syntheses and evaluation of some mannich bases derived from acetophenones against P388 lymphocytic leukemia and toxicological assessment of 3-dimethyl-amino-2-dimethylaminomethyl-1-(4-methoxyphenyl)-1-propanone dihydrochloride in rats."
08/01/1983 - "Evaluation of some Mannich bases derived from substituted acetophenones against P-388 lymphocytic leukemia and on respiration in isolated rat liver mitochondria."
08/01/1979 - "Analogs of some antineoplastic and cytotoxic Mannich bases derived from conjugated styryl ketones were prepared and evaluated for activity in the P-388 lymphocytic leukemia screen. "
02/01/1975 - "A number of nuclear-substituted styryl ketones, the related Mannich bases, and allyl alcohols were synthesized and evaluated for antitumor activity, principally in the L-1210 lymphoid leukemia and P-388 lymphocytic leukemia screening tests. "
01/01/2005 - "Other potential malaria chemoprophylactic drugs such as third-generation antifol compounds and Mannich bases have reached advanced preclinical testing. "
12/01/1984 - "The chemotherapy of rodent malaria, XXXVII. The in vivo action of two Mannich bases, WR 194,965 and WR 228,258 and an 8-aminoquinoline WR 225,448."
|5.||Colonic Neoplasms (Colon Cancer)
11/01/2000 - "The average cytotoxicity of the dienones 2 was more than three times greater than was found with the monoarylidene analogues 1, and, in general, were slightly more cytotoxic than the Mannich bases 3-5. A number of the compounds displayed potency towards a panel of human tumour cell lines and most of the representative compounds in series 2-5 were selectively toxic to colon cancers and leukaemic cells."
10/19/2000 - "In addition, the significant potencies of some of the Mannich bases toward human tumor cell lines, in particular coupled to their selective toxicity toward human leukemic and colon cancer cells, confirms their usefulness in serving as lead molecules for further development. "
|7.||Mechlorethamine (Nitrogen Mustard)
|9.||Oxyquinoline (8 Hydroxyquinoline)
|1.||Transplantation (Transplant Recipients)
|3.||Drug Therapy (Chemotherapy)