Manganese

A trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)

Networked: 3248 relevant articles (69 outcomes, 427 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Aschner, Michael: 96 articles (11/2022 - 01/2002)
2.	Bowman, Aaron B: 29 articles (01/2022 - 01/2010)
3.	Kim, Yangho: 20 articles (12/2017 - 12/2003)
4.	Zheng, Wei: 19 articles (12/2020 - 03/2004)
5.	Lee, Eunsook: 17 articles (10/2022 - 01/2014)
6.	Batinic-Haberle, Ines: 16 articles (01/2021 - 08/2004)
7.	Erikson, Keith M: 15 articles (12/2021 - 01/2002)
8.	Liu, Wei: 14 articles (10/2022 - 08/2016)
9.	Anantharam, Vellareddy: 13 articles (12/2019 - 04/2005)
10.	Kanthasamy, Arthi: 13 articles (12/2019 - 04/2005)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2022 - "The apoptosis and ferroptosis jointly render the manganese-based agent potent efficacy with tumor-targeting specificity in antitumor treatment under electric stimulation." 07/27/2021 - "Fenton-like reactions driven by manganese-based nanostructures have been widely applied in cancer treatment owing to the intrinsic physiochemical properties of these nanostructures and their improved sensitivity to the tumor microenvironment. " 01/01/2013 - "Ultrashort echo time for improved positive-contrast manganese-enhanced MRI of cancer." 01/01/2023 - "In this study, a facile and green synthesis method is proposed for the preparation of a manganese ion (Mn2+)-based immunostimulatory MOF (ISAMn-MOF) for cancer metalloimmunotherapy. " 11/01/2016 - "In this study, a fluorescent manganese(II) nanoparticle, labeled as (PEG-Mn-BDA), was synthesized and used as both fluorescent and MRI imaging agents in cancer cells. "
2.	Parkinsonian Disorders (Parkinsonism) 02/01/2016 - "Chronic manganese intoxication has an insidious and progressive course terminating to atypical parkinsonism with little therapeutic efficacy. " 01/01/2023 - "Manganese-Induced Parkinsonism: Evidence from Epidemiological and Experimental Studies." 01/01/2020 - "Our study focused on epidemiological, clinical, toxicological and experimental aspects of Manganese-induced Parkinsonism in south of Morocco. " 11/01/2017 - "Previous studies showed that overexposure to manganese causes parkinsonism, a disorder of dopaminergic neurons. " 09/17/2015 - "Although both metallic NPs proved adversely bio-active in many respects considered in this study, Mn₃O₄-NPs were somewhat more noxious than NiO-NPs as concerns most of the non-specific toxicity manifestations and they induced more marked damage to neurons in the striatum and the hippocampus, which may be considered an experimental correlate of the manganese-induced Parkinsonism. "
3.	Inflammation (Inflammations) 01/01/2023 - "Other pathological mechanisms mainly include manganese toxicity, autophagy inhibition, mitochondrial damage, inflammation, and senescence, proposing new avenues for future therapeutic interventions." 02/01/2022 - "Excessive exposure to manganese (Mn) is associated with neurotoxicity characterized by oxidative stress, inflammation, and apoptosis induction. " 05/01/2019 - "Excess exposure to Manganese (Mn) promotes oxidative stress and neuro-inflammation. " 01/01/2019 - "Divalent manganese (Mn2+) exposure can stimulate neurotoxicity by increasing inflammation. " 01/01/2018 - "Histopathological evaluation of the caudal nasal cavity showed moderate, acute to subacute suppurative inflammation of the olfactory epithelium and submucosa of the ethmoid turbinates and mild suppurative exudate in the nasal sinuses in animals given manganese. "
4.	Liver Diseases (Liver Disease) 05/01/1996 - "As dietary manganese is normally cleared by the liver, we hypothesize that hepatic dysfunction could lead to manganese overload and account for the MRI abnormalities seen in patients with chronic liver disease. " 12/01/1994 - "As manganese is primarily cleared by the liver, inadequate elimination of manganese absorbed from the normal diet may lead to manganese overload in patients with liver disease. " 01/01/2023 - "Our findings imply that SLC30A10-T95I either has a complex association with liver injury that extends beyond the simple reduction in SLC30A10 activity or alternatively the T95I mutation lacks a causal role in liver disease.NEW & NOTEWORTHY This study demonstrates that the T95I polymorphism in the manganese transporter SLC30A10, which has been associated with liver disease in human GWAS studies, does not impact transporter function in cell culture. " 09/05/2012 - "Air manganese levels and chronic liver disease mortality in North Carolina counties: an ecological study." 11/01/1996 - "In the present study, blood manganese concentrations were measured by atomic absorption spectrometry together with MRI and neurological evaluation in 57 cirrhotic patients with various etiologies and severity of liver disease. "
5.	Infections 10/01/2000 - "The assumption that one possible mechanism of action could be that manganese at such exposure levels disturbs certain protective functions in the lung--thus making the organism more susceptible to infections--is supported by toxicological studies. " 12/01/1982 - "On the 14th day of the infections, all four coccidial infections increased manganese absorption two- to fourfold that found in the controls in one trial but not in the second trial. " 01/01/2023 - "Bio-Functionalized Manganese Nanoparticles Suppress Fusarium Wilt in Watermelon (Citrullus lanatus L.) by Infection Disruption, Host Defense Response Potentiation, and Soil Microbial Community Modulation." 01/01/2022 - "Here we review the molecular details of host-streptococcal interactions in the battle for manganese during infection and the significance of streptococcal effectors involved to bacterial pathophysiology." 01/01/2022 - "In response to invading pathogens, the host recruits nutritional immune effectors at infection sites to withhold manganese from the pathogens and control bacterial growth. "

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7.	Copper
8.	Superoxide Dismutase
9.	Enzymes
10.	Ascorbic Acid (Vitamin C)

Related Therapies and Procedures

1.	Therapeutics
2.	Photothermal Therapy
3.	Immunotherapy
4.	Photochemotherapy (Photodynamic Therapy)
5.	Renal Dialysis (Hemodialysis)