|1.||Lopaschuk, Gary D: 15 articles (08/2014 - 09/2002)|
|2.||Saha, Asish K: 6 articles (03/2015 - 05/2002)|
|3.||Chohnan, Shigeru: 4 articles (01/2014 - 10/2007)|
|4.||Moran, Timothy H: 4 articles (06/2013 - 10/2007)|
|5.||Gao, Su: 4 articles (06/2013 - 10/2007)|
|6.||Lane, M Daniel: 4 articles (02/2011 - 05/2006)|
|7.||Dyck, Jason R B: 4 articles (08/2010 - 09/2002)|
|8.||Ussher, John R: 4 articles (06/2010 - 01/2008)|
|9.||Menendez, Javier A: 4 articles (12/2006 - 06/2004)|
|10.||Lupu, Ruth: 4 articles (12/2006 - 06/2004)|
05/01/2006 - "The concomitant increase in IMCL with the fall of malonyl-CoA support the concept that, as a reaction to starvation-induced FFA availability, muscle will activate lipid oxidation more the lower its oxidative capacity and then store the rest as IMCL."
05/01/2006 - "The decreases of malonyl-CoA in wTA and EDL during starvation were more pronounced in lean than in obese rats, although there were no changes in soleus muscles for both groups. "
06/01/1999 - "In contrast, during refeeding after starvation, the increase in malonyl-CoA in muscle is probably due to another mechanism."
09/15/1995 - "Peroxisomal and microsomal CPT also had decreased sensitivity to inhibition by malonyl-CoA during starvation. "
09/15/1995 - "Regulation of malonyl-CoA sensitivity of CPT-I in isolated mitochondrial outer membranes was indicated by an 8-fold increase in Ki during starvation and by a 50-fold increase in Ki in the diabetic state. "
|2.||Pathologic Constriction (Stenosis)
|3.||Breast Neoplasms (Breast Cancer)
01/01/2005 - "Paradoxically, high-dose GLA treatments of FAS-overexpressing breast cancer cells will promote malonyl-CoA-induced inhibition of CPT-I and FA oxidation, thus precipitating an energy crisis that triggers decreased proliferation or apoptotic cell death. "
11/01/2003 - "Recent data has shown that C75 directly stimulates CPT-1 increasing fatty acid oxidation in MCF-7 human breast cancer cells despite inhibitory concentrations of malonyl-CoA. "
08/20/2009 - "Similar to MCD siRNA, MPA inhibits MCD activity in MCF7 cells, increases cellular malonyl-CoA levels and is cytotoxic to a number of human breast cancer cell lines in vitro. "
06/01/2006 - "Collectively, our results indicate that inhibition of FAS in breast cancer cells causes accumulation of malonyl-CoA, which leads to inhibition of CPT-1 and up-regulation of ceramide and induction of the proapoptotic genes BNIP3, TRAIL, and DAPK2, resulting in apoptosis."
07/09/2002 - "C75 treatment of rodent adipocytes and hepatocytes and human breast cancer cells increased fatty acid oxidation and ATP levels by increasing CPT-1 activity, even in the presence of elevated concentrations of malonyl-CoA. "
07/09/2002 - "Studies in human cancer cells showed that C75 competed with malonyl-CoA, as measured by CPT-1 activity assays. "
08/01/2005 - "These findings indicate that accumulation of malonyl-CoA is not a prerequisite for cytotoxicity induced by inhibition of tumor-associated lipogenesis and suggest that in addition to FAS, ACC-alpha is a potential target for cancer intervention."
01/15/2000 - "The data suggest that differences in intermediary metabolism render tumor cells susceptible to toxic fluxes in malonyl-CoA, both in vitro and in vivo."
04/01/2009 - "Decrease in malonyl-CoA and its background metabolic alterations in murine model of cancer cachexia."
08/20/2009 - "Fatty acid synthase (FAS) inhibition initiates selective apoptosis of cancer cells both in vivo and in vitro, which may involve malonyl-CoA metabolism. "
02/01/2011 - "Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity."
01/15/2007 - "This review will focus on the emerging role of malonyl-CoA as a key "metabolic effector" of both obesity and cardiac fatty acid oxidation. "
10/15/2006 - "In muscle, increased malonyl-CoA, decreased muscle CPT1 activity, and increased IML have all been reported in obesity. "
02/01/2006 - "These findings indicate that nutritional modulation of the hypothalamic abundance of malonyl-coenzyme A is required to restrain food intake and that a primary impairment in this central nutrient-sensing pathway is sufficient to disrupt energy homeostasis and induce obesity."
01/15/2007 - "Both hypothalamic and cardiac studies have demonstrated that control of malonyl-CoA levels has an important impact on obesity and heart disease. "
|1.||Palmitoyl Coenzyme A (Palmitoyl CoA)
|2.||Acetyl Coenzyme A (Acetyl-CoA)
|3.||Carnitine O-Palmitoyltransferase (Carnitine Palmitoyltransferase II)
|4.||Fatty Acid Synthetase Complex (Fatty Acid Synthase)
|5.||Fatty Acids (Saturated Fatty Acids)
|10.||5-(tetradecyloxy)-2-furancarboxylic acid (TOFA)
|1.||Heterologous Transplantation (Xenotransplantation)