Mallory-Weiss Syndrome

A condition characterized by mucosal tears at the ESOPHAGOGASTRIC JUNCTION, sometimes with HEMATEMESIS. Typically it is caused by forceful bouts of retching or VOMITING.

Also Known As:

Gastroesophageal Laceration-Hemorrhage; Mallory-Weiss Laceration; Mallory-Weiss Tear; Mucosal Lacerations-Gastroesophageal Junction; Gastroesophageal Laceration Hemorrhage; Gastroesophageal Laceration-Hemorrhages; Junction, Mucosal Lacerations-Gastroesophageal; Junctions, Mucosal Lacerations-Gastroesophageal; Laceration, Mallory-Weiss; Laceration-Hemorrhage, Gastroesophageal; Laceration-Hemorrhages, Gastroesophageal; Lacerations-Gastroesophageal Junction, Mucosal; Lacerations-Gastroesophageal Junctions, Mucosal; Mallory Weiss Laceration; Mallory Weiss Syndrome; Mallory Weiss Tear; Mucosal Lacerations Gastroesophageal Junction; Mucosal Lacerations-Gastroesophageal Junctions; Syndrome, Mallory-Weiss

Networked: 99 relevant articles (4 outcomes, 5 trials/studies)

Relationship Network

Disease Context: Research Results

Digestive System Diseases: 1042
- Gastrointestinal Diseases: 5874
  - Esophageal Diseases: 379
    - Esophageal Perforation: 795
      - Mallory-Weiss Syndrome: 99

Related Diseases

1.	Hemorrhage
2.	Peptic Ulcer (Peptic Ulcers)
3.	Shock
4.	Diverticular Diseases
5.	Stomach Ulcer (Gastric Ulcer)

Experts

1.	Fang, Deng-Feng: 1 article (03/2022)
2.	Liu, Bin: 1 article (03/2022)
3.	Tang, Miao-Miao: 1 article (03/2022)
4.	Hamamoto, Wataru: 1 article (03/2022)
5.	Horie, Yasushi: 1 article (03/2022)
6.	Isomoto, Hajime: 1 article (03/2022)
7.	Kawahara, Shiho: 1 article (03/2022)
8.	Koda, Hiroki: 1 article (03/2022)
9.	Matsumoto, Kazuya: 1 article (03/2022)
10.	Onoyama, Takumi: 1 article (03/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Mallory-Weiss Syndrome:

1.	Hemostatics (Antihemorrhagics)IBA 01/01/1991 - "We have carried out a retrospective review of 61 patients with Mallory-Weiss syndrome, 9 of whom underwent hemostatic injection treatment. " 01/01/2016 - "Tulip-bundle technique as rescue hemostatic therapy in a deep Mallory-Weiss tear." 06/01/2002 - "The endoscopic hemostatic method has been introduced as a safe and effective mechanical approach to hemostasis for upper gastrointestinal bleeding related to Mallory-Weiss syndrome (MWS). " 07/01/2004 - "Effective hemostatic treatment is mandatory for patients with actively bleeding Mallory-Weiss syndrome. " 04/07/2008 - "To compare the hemostatic efficacy and safety of two mechanical endoscopic methods: endoscopic band ligation (EBL) and endoscopic hemoclip placement (EHP) in patients with actively bleeding Mallory-Weiss syndrome (MWS). "
2.	Epinephrine (Adrenaline)FDA LinkGeneric 06/01/2002 - "Thirty-five patients with Mallory-Weiss syndrome with spurting vessels or oozing in a university hospital were enrolled prospectively and randomly assigned to endoscopic hemoclip placement (18 patients) or endoscopic epinephrine injection (17 patients) performed by 4 endoscopists with similar clinical experiences. " 06/01/2002 - "This is an investigation of the respective efficacy and safety of endoscopic hemoclip placement and endoscopic epinephrine injection in Mallory-Weiss syndrome. " 07/01/2004 - "This study evaluated the respective efficacy and the safety of endoscopic band ligation and endoscopic epinephrine injection in Mallory-Weiss syndrome. " 06/01/2002 - "Endoscopic hemoclip placement and epinephrine injection for Mallory-Weiss syndrome with active bleeding." 07/01/2004 - "In this small study, no difference was detected in the efficacy or the safety of band ligation vs. epinephrine injection for the treatment of actively bleeding Mallory-Weiss syndrome."
3.	ElectrolytesIBA 05/01/1980 - "Mallory-Weiss syndrome induced by the oral electrolyte overload technique for colonoscopy preparation." 01/01/2009 - "Most commonly reported were electrolyte disturbances, renal failure and colonic ulceration for NaP and Mallory-Weiss tear, electrolyte disturbances and allergic reactions for PEG between January 2006 and December 2007; there were 171 cases of renal failure reported to the FDA following use of NaP and 10 following PEG. " 03/01/1992 - "I have reported two cases of Mallory-Weiss tear occurring after the patients drank an oral electrolyte/polyethylene glycol preparation before colonoscopy. " 11/01/1995 - "Polyethylene glycol electrolyte lavage solution-induced Mallory-Weiss tear." 05/01/1991 - "Mallory-Weiss tear associated with polyethylene glycol electrolyte lavage solution."
4.	CausticsIBA 09/01/1990 - "The authors presented the results of diagnostic and therapeutic esophagogastroduodenoscopy in the Mallory-Weiss syndrome observed in patients with acute ++non-caustic poisoning. " 09/01/1990 - "[Mallory-Weiss syndrome in acute poisoning with non-caustic substances]." 11/01/1998 - "Pathological changes in the gastroesophageal mucosa are described, causing gastrointestinal hemorrhages in patients with acute oral poisonings with non-caustic chemicals: the Mallory-Weiss syndrome, traumatic and erosive involvement of the gastroesophageal mucosa. " 06/01/1981 - "Further frequent sources of bleeding were duodenal ulcers, a Mallory-Weiss-syndrome, reflux-oesophagitis with hiatal hernia, erosions and polyps of the stomach and corrosive oesophagitis. " 08/01/2020 - "Acquired ones are secondary to reflux esophagitis, corrosive esophageal injury, drug-induced esophagitis, radiation esophagitis, Crohn's disease, Mallory-Weiss syndrome, malignant tumors, and infections like candidiasis, HSV, CMV, or tuberculosis. "
5.	SolutionsIBA 07/01/2004 - "Thirty-four consecutive patients with actively bleeding Mallory-Weiss syndrome were prospectively enrolled and were randomly assigned to undergo endoscopic band ligation or endoscopic injections of a 1:10,000 solution of epinephrine. " 11/01/1995 - "Polyethylene glycol electrolyte lavage solution-induced Mallory-Weiss tear." 05/01/1991 - "Mallory-Weiss tear associated with polyethylene glycol electrolyte lavage solution."
6.	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 03/01/1992 - "I have reported two cases of Mallory-Weiss tear occurring after the patients drank an oral electrolyte/polyethylene glycol preparation before colonoscopy. " 11/01/1995 - "Polyethylene glycol electrolyte lavage solution-induced Mallory-Weiss tear." 05/01/1991 - "Mallory-Weiss tear associated with polyethylene glycol electrolyte lavage solution."
7.	Ipecac (Syrup of Ipecac)IBA 06/01/1984 - "Ipecac as a cause of the Mallory-Weiss syndrome." 10/01/1981 - "Mallory-Weiss syndrome: an unusual complication of ipecac-induced emesis."
8.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 10/01/2011 - "Complications necessitating early removal included valve malfunction (1), gastritis (1), Mallory-Weiss tear (1), NSAID (2× dose/2 weeks) perforating ulcer (1), and balloon deflation (1). " 05/01/2005 - "The patients of this case-control study were NSAID users who had received NSAIDs for at least 3 days and were gastroscoped The patients with a history of gastrointestinal varices, gastrointestinal cancer, chronic renal failure, coagulopathy, or Mallory-Weiss tear were excluded. "
9.	AntralIBA 12/03/2020 - "The most frequent non-variceal findings which represent about two-thirds of the cases were duodenal ulcer (20.53%), antral gastropathy (13.68%), gastric ulcer (12.32%), antral gastritis (10.94%), and duodenal/gastric mass (9.57%), whereas much less frequent findings representing a total of 16.39% of cases included Cameron gastropathy, gastropathy/duodenopathy, esophagitis/gastritis, gastritis/duodenitis, gastroesophageal reflux disease (GERD), and Mallory-Weiss tear. " 08/01/2002 - "Twenty hours after the successful procedure, in which both IIAs were preserved, the patient regurgitated coffee-ground vomit; an upper gastrointestinal endoscopy found a small Mallory-Weiss tear and antral gastritis. "
10.	Factor VIIa (Activated Factor VII)IBA 07/01/2008 - "Successful management of Mallory-Weiss syndrome in a haemophilia A patient with inhibitor by recombinant activated factor VII."

Therapies and Procedures

1.	Endoscopic Hemostasis 10/01/1997 - "Endoscopic hemostasis may be effective in many of the conditions, but only Mallory-Weiss tear and Dieulafoy's lesion are encountered frequently enough to be clinically significant." 05/01/2014 - "One patient developed Mallory-Weiss syndrome, which required endoscopic hemostasis. " 01/01/2009 - "Endoscopic hemostasis with metallic hemoclips for iatrogenic Mallory-Weiss tear caused by endoscopic examination." 06/01/2002 - "Evaluation of endoscopic hemostasis in upper gastrointestinal bleeding related to Mallory-Weiss syndrome." 01/01/2015 - "Mallory-Weiss tear during the third trimester may have a possibility of massive hematemesis and urgent blood transfusion, emergency endoscopic hemostasis, and emergency cesarean section may be needed. "
2.	Ligation 07/01/2000 - "Severe Mallory-Weiss tear after endoscopy treated by endoscopic band ligation." 09/01/2006 - "This prospective study evaluated the efficacy and safety of endoscopic band ligation therapy for Mallory-Weiss syndrome. " 09/01/2006 - "The study results suggest that endoscopic band ligation is an effective, safe, and easily learned procedure for treating upper gastrointestinal bleeding related to Mallory-Weiss syndrome." 04/07/2008 - "Endoscopic band ligation and endoscopic hemoclip placement for patients with Mallory-Weiss syndrome and active bleeding." 11/01/2000 - "Mallory-Weiss syndrome with severe bleeding: treatment by endoscopic ligation."
3.	Therapeutics 01/01/1973 - "[Experimental studies on the pathogenesis and therapy of the Mallory-Weiss syndrome]." 06/01/2012 - "The clinical presentation, medical history, location and characteristics of Mallory-Weiss syndrome methods and effectiveness of therapy of patients with Mallory-Weiss syndrome were retrospectively analyzed by chart reviews. " 07/01/1990 - "Primal scream therapy: a new cause of Mallory-Weiss tear." 06/13/1975 - "[Therapy of the Mallory-Weiss syndrome]." 05/01/1972 - "The Mallory-Weiss syndrome: some unusual presentations and a suggested new therapy."
4.	Argon Plasma Coagulation 03/01/2016 - "The aim of the study was retrospective analysis of a selected group of patients with symptomatic upper gastrointestinal bleeding in the course of Mallory-Weiss syndrome, identification of typical characteristics of this disease entity in the studied population as well as demonstration of the effectiveness of endoscopic treatment using argon plasma coagulation (APC). "
5.	Surgical Instruments (Clip) 04/01/2010 - "The study involved 39 cases where hemostasis was attempted with bipolar forceps to deal with non-variceal upper gastrointestinal bleeding, including 28 cases of gastric ulcer, six cases of duodenal ulcer, three cases of bleeding after endoscopic submucosal dissection (ESD), one case of Mallory-Weiss syndrome and one case of postoperative bleeding from the anastomosed area. "