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Malate Dehydrogenase (Dehydrogenase, Malate)

An enzyme that catalyzes the conversion of (S)-malate and NAD+ to oxaloacetate and NADH. EC 1.1.1.37.
Also Known As:
Dehydrogenase, Malate; Malic Dehydrogenase; NAD-Malate Dehydrogenase; Dehydrogenase, Malic; Dehydrogenase, NAD-Malate; NAD Malate Dehydrogenase; (S)-Malate:NAD+ oxidoreductase
Networked: 264 relevant articles (4 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Sakthisekaran, D: 4 articles (05/2008 - 12/2001)
2. Arai, Toshiro: 3 articles (02/2013 - 11/2002)
3. Popova, T N: 3 articles (07/2009 - 05/2005)
4. Safonova, O A: 3 articles (07/2009 - 05/2005)
5. Streck, Emilio L: 2 articles (11/2015 - 08/2013)
6. Carvalho-Silva, Milena: 2 articles (11/2015 - 08/2013)
7. Anandakumar, Pandi: 2 articles (09/2015 - 02/2011)
8. Ahn, Keum-Young: 2 articles (09/2014 - 10/2007)
9. Lee, Jeewon: 2 articles (09/2014 - 10/2007)
10. Song, Jong-Am: 2 articles (09/2014 - 10/2007)

Related Diseases

1. Pancreatitis
05/01/1994 - "In this model of acute pancreatitis, reduced gastric adenylate energy charge levels were observed, and the leakage of the lysosomal enzyme, cathepsin B, from gastric lysosomes and of the mitochondrial enzyme, malate dehydrogenase, from gastric mitochondria were both significantly accelerated compared with the control group. "
06/01/1995 - "Acute pancreatitis caused an increase in lipofuscin accumulation, and a decrease in protein sulfhydryl groups in citrate synthetase (CS) and in malate dehydrogenase (MDH) activity. "
11/01/1991 - "This protease inhibitor prevented hyperamylasemia, pancreatic edema, congestion of amylase, and both amylase and lactic dehydrogenase (LDH) discharge from dispersed acini, as well as cathepsin B leakage from lysosomes and malate dehydrogenase (MDH) leakage from mitochondria in a dose-dependent manner, particularly in doses of 2 and 5 mg/kg.hr. Furthermore, the combined prophylactic and therapeutic use of this agent seems to be very effective in preventing caerulein induced pancreatitis. "
09/01/1992 - "To evaluate the effects of acute pancreatitis on the energy metabolism of the liver and on the fragility of hepatic cells and subcellular organelles, we studies (1) the arterial blood ketone body ratio (BKBR) (aceto acetate/beta-hydroxy butyrate), which is in equilibrium with the free NAD+/NADH ratio in liver mitochondria; (2) the hepatic energy charge (EC) = (ATP + 1/2 ADP)/(ATP + ADP + AMP); (3) the cathepsin B leakage from hepatic lysosomes and the malate dehydrogenase leakage from hepatic mitochondria in vitro; and (4) the protective effects of prostaglandin E2 (PGE2) and a new synthetic protease inhibitor ONO 3307 on hepatic injury in acute pancreatitis induced in rats by a supramaximal dose of caerulein. "
2. Body Weight (Weight, Body)
11/01/2015 - "HFE group decreased body weight gain, retroperitoneal and mesenteric adipose tissue relative weight, HOMA-IR, insulin levels and liver fat accumulation; increased complexes II-III and IV and malate dehydrogenase activities and improvement in glucose uptake in OGTT and insulin sensitivity by increased protein expression of total AKT, IRĪ± and IRS1. "
12/01/2007 - "Biorhythms with higher levels of activity of sorbitol dehydrogenase and lactate dehydrogenase in blood plasma, specific activity of sorbitol dehydrogenase, lactate dehydrogenase, and malate dehydrogenase in the liver, and body weight of rats were more pronounced in the spring-summer period than in the autumn-winter period. "
02/14/1984 - "Thyroxine (25 micrograms/100 g body weight) treatment for 1 month increased the specific activity of isocitrate dehydrogenase (NADP+) but the specific activities of ATP-citrate lyase, malate dehydrogenase and malic enzyme were inhibited. "
09/01/1981 - "When expressed in terms of units gm-1, the activities of enzymes functioning in oxidative metabolism (citrate synthase, beta-hydroxybutyrylCoA dehydrogenase, and malate dehydrogenase) decrease as body weight increases. "
04/25/2012 - "The ratio of liver weight to body weight, the parameters of mitochondria in hepatocyte and the contents of lactic acid in serum were measured; the open reading frame of cytoplasmic malate dehydrogenase (MDH1), mitochondrial malate dehydrogenase (MDH2), and the partial sequence of aspartate glutamate carrier (AGC) and oxoglutarate malate carrier (OMC) genes were cloned and sequenced; MDH1, MDH2, AGC and OMC mRNA levels were determined by real-time PCR; the specific activities of MDH1 and MDH2 in liver of plateau zokor and plateau pika were measured using enzymatic methods. "
3. Kidney Diseases (Kidney Disease)
4. Hyperamylasemia
5. Edema

Related Drugs and Biologics

1. Cathepsin B
2. Protease Inhibitors (Protease Inhibitor)
3. Caerulein (Ceruletide)
4. NAD (NADH)
5. Oxidoreductases
6. Glucose (Dextrose)
7. Adenosine Triphosphate (ATP)
8. Dinoprostone (PGE2)
9. Butyrates (Butyrate)
10. Adenosine Monophosphate (AMP)

Related Therapies and Procedures

1. Cardiopulmonary Resuscitation (CPR)
2. Radiotherapy
3. Microspheres (Microsphere)
4. Ligation
5. Lenses