1-Acylglycerophosphocholine O-Acyltransferase (1 Acylglycerophosphocholine O Acyltransferase)

An enzyme localized predominantly within the plasma membrane of lymphocytes. It catalyzes the transfer of long-chain fatty acids, preferentially unsaturated fatty acids, to lysophosphatides with the formation of 1,2-diacylglycero-3-phosphocholine and CoA. EC 2.3.1.23.

Also Known As:

1 Acylglycerophosphocholine O Acyltransferase; Acyl-CoA-1-Acylglycero-3-Phosphocholine-O-Acyltransferase; Lysophosphatidylcholine Acyltransferase; Lysophosphatidylcholine-Palmitoyl CoA Acyltransferase; Lysophospholipid Acyltransferase; 1 Acylglycerophosphocholine Acyltransferase; Acyl CoA 1 Acylglycero 3 Phosphocholine O Acyltransferase; Acyltransferase, 1-Acylglycerophosphocholine; Acyltransferase, Lysolecithin; Acyltransferase, Lysophosphatidylcholine; Acyltransferase, Lysophosphatidylcholine-Palmitoyl CoA; Acyltransferase, Lysophospholipid; CoA Acyltransferase, Lysophosphatidylcholine-Palmitoyl; Lysophosphatidylcholine Palmitoyl CoA Acyltransferase; O-Acyltransferase, 1-Acylglycerophosphocholine; 1-Acylglycerophosphocholine Acyltransferase; Acyl CoA Lysolecithin Acyltransferase; Lysolecithin Acyltransferase; Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase

Networked: 68 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Acyltransferases: 374
      - 1-Acylglycerophosphocholine O-Acyltransferase: 68
        Arabidopsis AT1G12640 protein
        CI-976-sensitive lysophospholipid acyltransferase
        Drosophila tafazzin protein
        human Lpcat1 protein
        human LPCAT2 protein
        human LPCAT3 protein
        human LPCAT4 protein
        mouse Lpcat1 protein
        mouse LPCAT2 protein
        mouse LPCAT3 protein
        mouse Lpcat4 protein
        S cerevisiae ALE1 protein

Experts

1.	Shimizu, Takao: 3 articles (08/2022 - 01/2017)
2.	Shindou, Hideo: 3 articles (08/2022 - 01/2017)
3.	Hube-Magg, Claudia: 3 articles (10/2021 - 12/2013)
4.	Sauter, Guido: 3 articles (10/2021 - 12/2013)
5.	Simon, Ronald: 3 articles (10/2021 - 12/2013)
6.	Grupp, Katharina: 2 articles (10/2021 - 12/2013)
7.	Prien, Kristina: 2 articles (01/2019 - 12/2013)
8.	Shiraishi, Seiji: 2 articles (01/2017 - 01/2014)
9.	Uezono, Yasuhito: 2 articles (01/2017 - 01/2014)
10.	Hayasaka, Takahiro: 2 articles (02/2016 - 08/2013)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2022 - "Recent studies have highlighted the critical role of lysophosphatidylcholine acyltransferase 3 (LPCAT3) during cancer development. " 10/28/2022 - "Lysophosphatidylcholine acyltransferase 1 (LPCAT1) is overexpressed in multiple human tumors. " 01/01/2019 - "Lysophosphatidylcholine acyltransferase 1 (LPCAT1) has been implicated with various cancer types. " 01/01/2019 - "Here, we show that the lysophosphatidylcholine acyltransferase LPCAT1 functionally links specific genetic alterations in cancer with aberrant metabolism and plasma membrane remodeling to drive tumor growth. " 12/01/2013 - "Lysophosphatidylcholine acyltransferase 1 (LPCAT1) has been suggested to play a role in cancer. "
2.	Inflammation (Inflammations) 01/01/2017 - "In the present study we demonstrate that primary chicken macrophages express PAFR and lysophosphatidylcholine acyltransferase 2 (LPCAT2), the latter being essential to PAF biosynthesis during inflammation. " 01/01/2018 - "Macrophage Lysophosphatidylcholine Acyltransferase 3 Deficiency-Mediated Inflammation Is Not Sufficient to Induce Atherosclerosis in a Mouse Model." 07/01/2022 - "Lysophosphatidylcholine acyltransferase 3 (LPCAT3) mediates palmitate-induced inflammation in macrophages of large yellow croaker (Larimichthys crocea)." 12/01/2015 - "Lentiviral vector-mediated delivery of lysophosphatidylcholine acyltransferase 1 attenuates airway inflammation in ovalbumin-induced allergic asthmatic mice." 06/17/2011 - "The recently identified key enzymes of the Lands cycle, lysophosphatidylcholine acyltransferase 1 and 2 (LPCAT1 and -2), were reported to localize to the endoplasmic reticulum and to function in lung surfactant production and in inflammation response. "
3.	Pain (Aches) 01/01/2017 - "In the present study, we found that pain-like behaviors resulting from partial sciatic nerve ligation (PSL) were largely attenuated by deficiency of lysophosphatidylcholine acyltransferase (LPCAT)2, which is one of the PAF biosynthetic enzymes. "
4.	Insulin Resistance 11/01/2023 - "Previous studies have revealed that membrane phospholipid composition controlled by lysophosphatidylcholine acyltransferase 3 (LPCAT3) is involved in the development of insulin resistance in type 2 diabetes. "
5.	Type 2 Diabetes Mellitus (MODY) 11/01/2023 - "Previous studies have revealed that membrane phospholipid composition controlled by lysophosphatidylcholine acyltransferase 3 (LPCAT3) is involved in the development of insulin resistance in type 2 diabetes. "

Related Drugs and Biologics

1.	Enzymes
2.	Phospholipids (Phosphatides)
3.	Phosphatidylcholines (Phosphatidylcholine)
4.	Lysophosphatidylcholines (Lysophosphatidylcholine)
5.	Acyl Coenzyme A (Acyl CoA)
6.	Phospholipases A2 (Phospholipase A2)
7.	Proteins (Proteins, Gene)
8.	Phosphotransferases (Kinase)
9.	Lipids
10.	Phosphatidylcholine-Sterol O-Acyltransferase (Lecithin Cholesterol Acyltransferase)

Related Therapies and Procedures

1.	Ligation
2.	Therapeutics
3.	Transplantation
4.	Punctures