Lysinoalanine

N(6)-(2-Amino-2-carboxyethyl)-L-lysine. An unusual amino acid, not a dipeptide, which has been found in proteins of cooked foods. It is formed in food that is heated or treated with alkali. Has been implicated in nephrocytomegalia in rats.

Also Known As:

Networked: 7 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Brem, Jürgen: 1 article (01/2022)
2.	Lang, Pauline A: 1 article (01/2022)
3.	Lohans, Christopher T: 1 article (01/2022)
4.	Rabe, Patrick: 1 article (01/2022)
5.	Raj, Ritu: 1 article (01/2022)
6.	Robinson, Carol V: 1 article (01/2022)
7.	Schofield, Christopher J: 1 article (01/2022)
8.	Tumber, Anthony: 1 article (01/2022)
9.	Hard, Gordon C: 1 article (01/2018)
10.	Bian, Jiang: 1 article (01/2016)

Related Diseases

1.	Constipation 08/15/2023 - "The combination of defatted hempseed meal and probiotics was found to be effective in relieving constipation, probably due to the enriched amino acids and peptides, such as Thr-Leu and lysinoalanine through correlation analysis. "
2.	Dehydration (Water Stress) 01/01/2022 - "In addition to observation of previously identified inhibitor-induced SBL modifications, the results reveal that prolonged reaction of penam sulfones with SBLs can induce dehydration of the nucleophilic serine to give a dehydroalanine residue that undergoes reaction to give a previously unobserved lysinoalanine cross-link. " 06/15/1995 - "Lantibiotics are synthesised on the ribosome as a prepeptide which undergoes several post-translational modification events, including dehydration of specific hydroxyl amino acids to form dehydroamino acids, addition of neighbouring sulfhydryl groups to form thioethers and, in specific cases, other modifications such as introduction of D-alanine residues from L-serine, formation of lysinoalanine bridges, formation of novel N-terminal blocking groups and oxidative decarboxylation of a C-terminal cysteine. "
3.	Interstitial Nephritis (Tubulointerstitial Nephritis) 01/01/2018 - ": BEN: Balkan Endemic Nephropathy; DMN: dimethylnitrosamine; GLP: Good Laboratory Practice; KIN: karyomegalic interstitial nephritis; LAL: lysinoalanine; MeCCNU: 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea; NTP: National Toxicology Program; OSOM: outer stripe of outer medulla; OTA: ochratoxin A; RTT: renal tubule tumor."
4.	Neoplasms (Cancer) 01/01/2018 - ": BEN: Balkan Endemic Nephropathy; DMN: dimethylnitrosamine; GLP: Good Laboratory Practice; KIN: karyomegalic interstitial nephritis; LAL: lysinoalanine; MeCCNU: 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea; NTP: National Toxicology Program; OSOM: outer stripe of outer medulla; OTA: ochratoxin A; RTT: renal tubule tumor."
5.	Lyme Disease (Disease, Lyme) 12/01/2023 - "We previously demonstrated that the oral pathogen Treponema denticola (Td) and Lyme disease pathogen Borreliella burgdorferi (Bb) form covalent lysinoalanine (Lal) cross-links between conserved cysteine and lysine residues of the FlgE protein that composes the flagellar hook. "

Related Drugs and Biologics

1.	Amino Acids
2.	Peptides (Polypeptides)
3.	Serine (L-Serine)
4.	Cysteine (L-Cysteine)
5.	dehydroalanine
6.	Hydroxyl Radical
7.	Sulfones
8.	Sulfides (Thioethers)
9.	Semustine
10.	Proteins (Proteins, Gene)