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2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine (Lysyl Hydroxylase)

A mixed-function oxygenase that catalyzes the hydroxylation of peptidyllysine, usually in protocollagen, to peptidylhydroxylysine. The enzyme utilizes molecular oxygen with concomitant oxidative decarboxylation of the cosubstrate 2-oxoglutarate to succinate. EC 1.14.11.4.
Also Known As:
Lysyl Hydroxylase; Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase; Collagen Lysyl Hydroxylase; 2-Oxoglutarate Dioxygenase, Lysine; 5-Dioxygenase Procollagen-Lysine, 2-Oxoglutarate; Dioxygenase, Lysine 2-Oxoglutarate; Hydroxylase, Collagen Lysyl; Hydroxylase, Lysine; Hydroxylase, Lysyl; Hydroxylase, Protocollagen Lysyl; Lysine 2 Oxoglutarate Dioxygenase; Procollagen Lysine, 2 Oxoglutarate 5 Dioxygenase; Lysine 2-Oxoglutarate Dioxygenase; Lysine Hydroxylase; Protocollagen Lysyl Hydroxylase; Procollagen-L-lysine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating)
Networked: 65 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Bank, Ruud A: 4 articles (06/2005 - 10/2003)
2. Walker, L C: 4 articles (12/2004 - 02/2000)
3. Giunta, Cecilia: 3 articles (01/2011 - 03/2005)
4. Yeowell, Heather N: 3 articles (09/2005 - 12/2004)
5. Steinmann, Beat: 3 articles (09/2005 - 07/2002)
6. Zuurmond, Anne-Marie: 3 articles (06/2005 - 10/2003)
7. Yeowell, H N: 3 articles (09/2000 - 02/2000)
8. Yamauchi, Mitsuo: 2 articles (03/2015 - 05/2005)
9. Bank, R A: 2 articles (01/2013 - 10/2005)
10. Fukushima, Yoshimitsu: 2 articles (08/2011 - 06/2010)

Related Diseases

1. Ehlers-Danlos Syndrome (Syndrome, Ehlers-Danlos)
2. Neoplasm Metastasis (Metastasis)
3. Neoplasms (Cancer)
4. Fibrosis (Cirrhosis)
5. Anoxia (Hypoxia)

Related Drugs and Biologics

1. Collagen
2. Lysine (L-Lysine)
3. Messenger RNA (mRNA)
4. Nonsense Codon (Nonsense Mutation)
5. Hydroxylysine
6. Collagen Type IV (Type IV Collagen)
7. Procollagen
8. Hydralazine (Apresoline)
9. Collagen Type II (Type II Collagen)
10. Collagen Type I (Type I Collagen)