Lymphokines

09/01/1991 - "Although normally produced in vivo in very small quantities, the widespread availability of recombinant lymphokines has made it possible to study the molecular signals involved in production of lymphocyte effectors with activity against tumor. "
05/01/1991 - "In vitro studies demonstrated that this may have reflected secretion of lymphokines that activated macrophages to lyse the tumor. "
03/01/1986 - "In this brief review, we have focused on studies demonstrating the existence of low-molecular-weight lymphokines that modify a number of tumor cell functions. "
01/01/1985 - "The purpose of these studies was to determine whether stimulated human lymphocytes produce lymphokines distinct from IFN gamma, that can activate human blood monocytes to lyse tumor cells. "
06/01/1982 - "In the present study, this tumor migration inhibition activity has been characterized in order to determine whether the responsible factor is the same or different from other known migration-inhibitory lymphokines. "

01/01/1990 - "Similarly, attempts at harnessing the graft-versus-leukemia effect without the eligibility restrictions and toxicities associated with the allograft procedure, through the use of lymphokines as enhancers of natural killer cell activity, have also proven to be effective in pre-clinical trials. "
03/01/1987 - "The human promyelocytic leukemia cell line HL60 differentiates to either granulocytes or monocytes/macrophages when induced with various chemicals and lymphokines. "
01/01/1987 - "Macrophages from guinea pigs terminally ill with L2C leukemia were demonstrated to be depressed in their cytotoxic activity against the K562 cell after stimulation by either LPS or lymphokines when compared to normal macrophages. "
11/15/1986 - "We have used a lymphokine-responsive clone (3B3) of B leukemia cells (BCL1) to examine the effects of several recombinant and purified lymphokines. "
05/01/1986 - "Inhibitory activity of HL-60 cells was diminished after they were induced to differentiate, indicating that differentiation induced by lymphokines may be an effective means of controlling leukemia."

10/01/1986 - "PEC stimulated with lymphokines in vitro was also effective in inhibiting metastasis. "
04/15/1988 - "Therefore this study was undertaken to investigate the antitumor efficacy of these lymphokines in a disseminated pulmonary metastasis when used in combination with each other at dosages well below the toxic level. "
08/01/1987 - "These data also suggest that a possible physiologic function of the stable cytotoxic lymphokines is to induce cytolysis/cytostasis of cells that have lost gap junctional contact, such as those in the process of mitosis or metastasis that have separated from the main tissue mass."
02/01/1982 - "(a) When macrophage-activating agents such as lymphokines of MDP were delivered in liposomes that were not efficiently retained in the lung, little or no activation of lung macrophages was observed, and growth of metastases was unaltered. "
01/01/1992 - "When these cells are reinfused into cancer patients after in vitro expansion with lymphokines such as interleukin 2 (rIL-2), they often induce regression of tumor metastases. "

07/01/1989 - "It was of interest to study in vitro the action of Con A-stimulated spleen cell lymphokines (LK) to protect or to cure liver macrophages from infection by L. "
01/01/1997 - "Immunoprophylaxis of Salmonella gallinarum infection by Salmonella enteritidis-immune lymphokines in broiler chicks."
10/01/1993 - "Immunoprophylaxis of Salmonella enteritidis infection by lymphokines in Leghorn chicks."
05/01/1993 - "This response depends upon secretion of specific lymphokines to recruit and activate immune cells at the site of infection. "
10/01/1992 - "We have postulated that during infection, intragraft CMV-specific lymphocytes are activated and release lymphokines that augment cellular rejection. "

09/01/1988 - "A better understanding of the role of lymphokines in the mechanisms involved in the development of autoimmunity and inflammation may be beneficial in the treatment of these diseases."
05/01/2004 - "Inflammation involves a universally recognized, although incompletely understood, cascade of molecular events orchestrated by lymphokines and other innate biochemicals of immunity. "
01/01/2003 - "These symptoms in MS may represent transient phenomena related to inflammation in acute plaques and probably are secondary to irritation of demyelinated axons by lymphokines. "
01/01/2001 - "Therefore, antigenic stimulation in the presence of inflammation produces an increased number of specific T cells capable of producing effector lymphokines throughout the body."
09/01/1997 - "To further understand the mechanisms suppressing immunogenic inflammation in the eye, we have examined the production of lymphokines by primed T-cells activated in the presence of aqueous humor. "