Lymphocytic Choriomeningitis

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99 relevant articles (1 outcomes, 5 trials/studies) found for this Disease

Description: A form of meningitis caused by LYMPHOCYTIC CHORIOMENINGITIS VIRUS. MICE and other rodents serve as the natural hosts, and infection in humans usually occurs through inhalation or ingestion of infectious particles. Clinical manifestations include an influenza-like syndrome followed by stiff neck, alterations of mentation, ATAXIA, and incontinence. Maternal infections may result in fetal malformations and injury, including neonatal HYDROCEPHALUS, aqueductal stenosis, CHORIORETINITIS, and MICROCEPHALY. (From Joynt, Clinical Neurology, 1996, Ch26, pp1-3)

Also Known As:

Armstrong's Syndrome; Encephalomyelitis, Lymphocytic Choriomeningitis Virus; Lymphocytic Choriomeningitis Virus Encephalomyelitis; Choriomeningitis, Lymphocytic; Syndrome, Armstrong; Syndrome, Armstrong's; Armstrong Syndrome

Relationship Network

Disease Context: Research Results

Virus Diseases: 1311

Viral Meningitis: 198

Lymphocytic Choriomeningitis: 99

RNA Virus Infections: 36

Arenaviridae Infections: 24

Lymphocytic Choriomeningitis: 99

Central Nervous System Viral Diseases: 8

Viral Meningitis: 198

Lymphocytic Choriomeningitis: 99

Nervous System Diseases: 3414

Central Nervous System Diseases: 930

Central Nervous System Infections: 238

Meningitis: 5704

Viral Meningitis: 198

Lymphocytic Choriomeningitis: 99

Central Nervous System Viral Diseases: 8

Viral Meningitis: 198

Lymphocytic Choriomeningitis: 99

Related Diseases

1.	Infection
2.	Glomerulonephritis
3.	Viremia
4.	Proteinuria
5.	Albuminuria

Experts

1.	Paddock, Christopher D: 1 article (05/2007)
2.	Erickson, Bobbie R: 1 article (05/2007)
3.	Nichol, Stuart T: 1 article (05/2007)
4.	Hannafin, Christopher H: 1 article (05/2007)
5.	Pavlin, Boris I: 1 article (05/2007)
6.	Comer, James A: 1 article (05/2007)
7.	Bandy, Utpala: 1 article (05/2007)
8.	Zaki, Sherif: 1 article (05/2007)
9.	Parsely, Melody S: 1 article (05/2007)
10.	Smith, Kathleen A: 1 article (05/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Lymphocytic Choriomeningitis:

1.	Cyclophosphamide (Cytoxan)FDA Link 01/01/1971 - "Cyclophosphamide-induced protection against acute lymphocytic choriomeningitis in mice." 10/01/1986 - "Bone marrow radiation chimeras have been used as virus-infected, cyclophosphamide-suppressed recipients to analyze the major histocompatibility complex (MHC) restriction constraints on the adoptive transfer of lymphocytic choriomeningitis by immune T cells" 10/01/1985 - "Consequences of cyclophosphamide treatment in murine lymphocytic choriomeningitis: evidence for cytotoxic T cell replication in vivo." 02/01/1985 - "Participation of cyclophosphamide-resistant T cells in murine lymphocytic choriomeningitis." 02/01/1985 - "Adoptively transferred immune spleen cells induce fatal neurological disease in cyclophosphamide-suppressed recipients injected intracerebrally (ic) with a large, but not small, dose of neurotropic lymphocytic choriomeningitis (LCM) virus" Order ALL the reference details at left...
2.	Messenger RNA (mRNA)IBA 07/01/1994 - "In the present study, injection of antiserum to IFN-alpha/beta prevented the development of lymphocytic choriomeningitis, was associated with the absence of detectable expression of early 2'-5' oligo-adenylate synthetase mRNA and coincided with viremia of lymphocytic choriomeningitis virus (LCMV) followed by establishment of a persistent infection" 09/01/1985 - "Previous studies have reported that the 3' half of the small, S, RNA species of the WE strain of lymphocytic choriomeningitis (LCM) virus codes for the viral nucleoprotein in a subgenomic, viral-complementary, mRNA species (Romanowski, V. and Bishop, D.H.L" Order ALL the reference details at left...
3.	NucleoproteinsIBA 12/01/2007 - "We have previously reported that lymphocytic choriomeningitis nucleoprotein (LCMV-NP) expressed in HEK cells (HEK-NP) induces cross-priming of CD8+ T cells in vivo" 09/15/1994 - "A major portion of the nucleoprotein (amino acids 67 through 300) and the glycoprotein-2 of lymphocytic choriomeningitis (LCM) virus were synthesized by using recombinant technology and were injected together with SDS twice in portions of 5 micrograms into BALB/c mice" 03/01/1989 - "Anti-viral protection and prevention of lymphocytic choriomeningitis or of the local footpad swelling reaction in mice by immunization with vaccinia-recombinant virus expressing LCMV-WE nucleoprotein or glycoprotein." 09/01/1985 - "Previous studies have reported that the 3' half of the small, S, RNA species of the WE strain of lymphocytic choriomeningitis (LCM) virus codes for the viral nucleoprotein in a subgenomic, viral-complementary, mRNA species (Romanowski, V. and Bishop, D.H.L" 10/01/1976 - "Disruption of purified lymphocytic choriomeningitis (LCM) virus with Nonidet P-40 in 0.5 M KCl followed by sucrose gradient centrifugation in 0.3 M KCl led to the isolation of two viral nucleoproteins (RNPs) as well as 40S and 60S ribosomal subunits" Order ALL the reference details at left...
4.	RNA (Ribonucleic Acid)IBA 06/01/1987 - "These results support the conclusion that in Tacaribe virus--as in Pichinde and lymphocytic choriomeningitis arenavirus-S RNA encodes the viral N and GPC proteins and has an 'ambisense' coding strategy" 02/01/1985 - "Analyses of the 3' end sequences of the small, S, and large, L, RNA species of lymphocytic choriomeningitis (LCM) virus isolates ARM and WE, and DNA clones of LCM-WE, have shown that there are extensive RNA sequence homologies between the 3' ends of the two RNA species of both LCM strains" 09/01/1985 - "Previous studies have reported that the 3' half of the small, S, RNA species of the WE strain of lymphocytic choriomeningitis (LCM) virus codes for the viral nucleoprotein in a subgenomic, viral-complementary, mRNA species (Romanowski, V. and Bishop, D.H.L" 12/01/1967 - "Reproducible plaquing system for rabies, lymphocytic choriomeningitis,k and other ribonucleic acid viruses in BHK-21-13S agarose suspensions." Order ALL the reference details at left...
5.	Monoclonal AntibodiesIBA 08/01/1981 - "Monoclonal antibodies to lymphocytic choriomeningitis and pichinde viruses: generation, characterization, and cross-reactivity with other arenaviruses." 01/01/1989 - "Monoclonal antibodies (mAb) with specificity for the T cell-associated serine proteinase-1 of the mouse (MTSP-1) were used to study expression and storage of this enzyme in T lymphocytes during lymphocytic choriomeningitis (LCM) virus infection in vivo" 01/01/1988 - "Of a total of 17 monoclonal antibodies (MAb) directed against structural proteins of the lymphocytic choriomeningitis (LCM) virus, 3 were specific for the viral nucleoprotein (p63) and attached to the plasma membrane of infected cells, as disclosed by the indirect immunofluorescence procedure and complement-mediated cytolysis" Order ALL the reference details at left...
6.	Antigen-Antibody Complex (Immune Complex)IBA 05/01/1977 - "Mice chronically infected with the virus of lymphocytic choriomeningitis (LCM) develop immune complex glomerulonephritis" 12/01/1975 - "Since albuminuria rather than proteinuria is the hallmark of glomerular disease, the present studies were designed to study the occurrence of albuminuria in normal mice (SWR/J strain) and in mice with a reproducible and predictable immune complex glomerulonephritis induced by chronic infection with lymphocytic choriomeningitis (LCM) virus" Order ALL the reference details at left...
7.	Serine (L-Serine)FDA Link 01/01/1989 - "Monoclonal antibodies (mAb) with specificity for the T cell-associated serine proteinase-1 of the mouse (MTSP-1) were used to study expression and storage of this enzyme in T lymphocytes during lymphocytic choriomeningitis (LCM) virus infection in vivo" Order ALL the reference details at left...
8.	LigasesIBA 07/01/1994 - "In the present study, injection of antiserum to IFN-alpha/beta prevented the development of lymphocytic choriomeningitis, was associated with the absence of detectable expression of early 2'-5' oligo-adenylate synthetase mRNA and coincided with viremia of lymphocytic choriomeningitis virus (LCMV) followed by establishment of a persistent infection" Order ALL the reference details at left...
9.	Diazepam (Valium)FDA LinkGeneric 01/01/1977 - "Because previous ultrastructural studies of murine lymphocytic choriomeningitis (LCM) had revealed only mononuclear cell infiltration with no cytopathology of target cells in the choroid plexus, ependyma, and leptomeninges, diazepam treatment was used to prolong survival for characterization of late pathogenetic events" Order ALL the reference details at left...
10.	AntibodiesIBA 01/01/1991 - "Specific antibodies to lymphocytic choriomeningitis (LCM) virus were detected in sera of wild rodents trapped in different regions of Egypt" 05/09/1977 - "Furthermore, no woman had any antibodies for the virus of lymphocytic choriomeningitis, another potentially teratogenic virus" 12/23/1973 - "Rapid diagnosis of viral lymphocytic choriomeningitis by detection of antibodies using immunofluorescence]" 01/01/1960 - "Demonstration, properties and significance of neutralizing antibodies in mature mice immune to lymphocytic choriomeningitis (LCM)." 09/01/1996 - "After intracerebral infection with LCMV-Armstrong, CD8+ T cell-mediated lethal lymphocytic choriomeningitis developed independently of the presence of B cells and antibodies" Order ALL the reference details at left...

Therapies and Procedures

1.	Transplants (Transplant) 05/01/2007 - "Pet rodents and fatal lymphocytic choriomeningitis in transplant patients." 10/15/1969 - "Interaction of graft-versus-host reaction and lymphocytic choriomeningitis infection in mice: histopathological changes." Order ALL the reference details at left...
2.	Homologous Transplantation (Allograft) 04/15/1996 - "Pancreatic TGF-beta1 did not delay allograft rejection, nor did it inhibit autoimmune diabetes after lymphocytic choriomeningitis infection of double transgenic mice (LCMV/TGF-beta1 mice)" Order ALL the reference details at left...
3.	Immunotherapy 01/01/1964 - "PASSIVE IMMUNOPROPHYLAXIS AND IMMUNOTHERAPY OF INHALATION LYMPHOCYTIC CHORIOMENINGITIS IN GUINEA-PIGS." Order ALL the reference details at left...

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