Discoid Lupus Erythematosus

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351 relevant articles (17 outcomes, 28 trials/studies) found for this Disease

Description: A chronic form of cutaneous lupus erythematosus (LUPUS ERYTHEMATOSUS, CUTANEOUS) in which the skin lesions mimic those of the systemic form but in which systemic signs are rare. It is characterized by the presence of discoid skin plaques showing varying degrees of edema, erythema, scaliness, follicular plugging, and skin atrophy. Lesions are surrounded by an elevated erythematous border. The condition typically involves the face and scalp, but widespread dissemination may occur.

Also Known As:

Lupus Erythematosus, Discoid; Lupus Erythematosus, Chronic Cutaneous; Lupus Erythematosus, Cutaneous, Chronic

Relationship Network

Disease Context: Research Results

Skin and Connective Tissue Diseases

Skin Diseases: 6187

Cutaneous Lupus Erythematosus: 331

Discoid Lupus Erythematosus: 351

Lupus Erythematosus Panniculitis: 27

Connective Tissue Diseases: 1692

Cutaneous Lupus Erythematosus: 331

Discoid Lupus Erythematosus: 351

Lupus Erythematosus Panniculitis: 27

Related Diseases

1.	Prurigo
2.	Systemic Lupus Erythematosus (Libman-Sacks Disease)
3.	Erythema Nodosum
4.	Lichen Planus (Lichen Ruber Planus)
5.	Aphthous Stomatitis (Aphthous Ulcer)

Experts

1.	Walker, S L: 2 articles (08/2002 - 11/2000)
2.	Henderson, Clifford L: 1 article (07/2008)
3.	Lafleur, Laci: 1 article (07/2008)
4.	Prochilo, T: 1 article (07/2008)
5.	Kildani, B: 1 article (07/2008)
6.	Beretta, G D: 1 article (07/2008)
7.	Lombardi, C: 1 article (07/2008)
8.	Sontheimer, Richard D: 1 article (07/2008)
9.	Bonetti, F: 1 article (07/2008)
10.	Merlin, F: 1 article (07/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Discoid Lupus Erythematosus:

1.	Thalidomide (Thalomid)FDA Link 01/01/1977 - "At the present time, the authors believe that thalidomide is the best treatment for Discoid Lupus Erythematosus." 06/01/2007 - "Systemic thalidomide has good effect on refractory chronic discoid lupus erythematosus (CDLE) whereas topical regimen of it has not been reported previously. " 06/01/2007 - "[Topical thalidomide having good effect on refractory chronic discoid lupus erythematosus: a case report]" 07/01/2006 - "CONCLUSION: Low-dose thalidomide treatment is an effective treatment option for discoid lupus erythematosus in cases resistant to other treatments. " 07/01/2006 - "[Thalidomide therapy for discoid lupus erythematosus]" Order ALL the reference details at left...
2.	Sulfasalazine (Azulfidine)FDA LinkGeneric 04/01/1997 - "Sulfasalazine is an effective agent for chronic discoid lupus erythematosus (CDLE) but the response to treatment is considerably variable between patients and is also unpredictable. " 04/01/1997 - "NAT2 genotyping and efficacy of sulfasalazine in patients with chronic discoid lupus erythematosus." 10/01/1996 - "Efficacy of sulfasalazine in discoid lupus erythematosus." 01/01/1997 - "If these results are confirmed by other studies, it would be possible to propose sulfasalazine as a treatment for discoid lupus erythematosus in rapid acetylators." 01/01/1997 - "We therefore conducted an open study in patients with discoid lupus erythematosus treated with sulfasalazine. " Order ALL the reference details at left...
3.	Antimalarials (Antimalarial Agents)IBA 07/01/1954 - "[A case of discoid lupus erythematosus cured by synthetic antimalarials.]" 01/01/2007 - "We present one case of cardiotoxicity in a 59-year-old woman treated with antimalarials during 13 years for a discoid lupus erythematosus. " 01/01/2003 - "Childhood discoid lupus erythematosus and antimalarials." 01/01/1959 - "The treatment of chronic discoid lupus erythematosus with antimalarial drugs." 10/01/1956 - "Relapse in discoid lupus erythematosus treated with antimalarial drugs." Order ALL the reference details at left...
4.	Antinuclear AntibodiesIBA 01/01/2004 - "Discoid lupus erythematosus was suspected, and serological testing yielded positive results for antinuclear antibody. " 02/01/1977 - "Antinuclear antibody studies in chronic cutaneous discoid lupus erythematosus." 11/01/1988 - "Anticardiolipin and antinuclear antibodies in discoid lupus erythematosus--their clinical significance." 10/01/1977 - "Anti-DNA antibodies have been detected previously in patients with chronic discoid lupus erythematosus (DLE) despite the absence of overt systemic manifestations. " 10/01/1977 - "Anti-DNA antibodies in discoid lupus erythematosus. " Order ALL the reference details at left...
5.	Clofazimine (Lamprene)FDA Link 03/01/1976 - "In dermatology, patients with nodosum leprosum and discoid lupus erythematosus are benefited by clofazimine therapy. " 12/01/1980 - "Further study of the use of clofazimine in discoid lupus erythematosus." 11/01/1987 - "A 70-year-old woman developed dark reddish blue pigmentation in scarred areas of discoid lupus erythematosus after taking clofazimine intermittently over a period of 10 years. " 11/01/1987 - "Autofluorescence of clofazimine in discoid lupus erythematosus." 12/01/1976 - "Clofazimine (laprene) in the treatment of discoid lupus erythematosus." Order ALL the reference details at left...
6.	GoldIBA 08/01/1986 - "Twenty-three patients with severe longstanding discoid lupus erythematosus, unresponsive to conventional treatments, were treated with oral gold in a multicentre open study. " 02/01/1960 - "Although gold therapy probably is as effective in discoid lupus erythematosus, the antimalarials are easier to administer and cause fewer serious side effects. " 08/01/1986 - "Treatment of chronic discoid lupus erythematosus with an oral gold compound (auranofin)." Order ALL the reference details at left...
7.	AntibodiesIBA 02/01/1977 - "The prevalence of antinuclar antibodies (ANA) in chronic cutaneous discoid lupus erythematosus (DLE) is influenced by both patient selection and test sensitivity. " 11/01/1985 - "Elevated levels of ssDNA antibodies were present in seven of the forty patients (significantly greater than control subjects; (p less than 0.005) and correlated with widespread, active discoid lupus erythematosus, an elevated erythrocyte sedimentation rate, and a slightly greater risk of systemic lupus erythematosus in 1982. " 12/01/2007 - "Limited cutaneous systemic sclerosis associated with discoid lupus erythematosus in two Japanese patients with anticentromere antibodies." 03/01/1999 - "Anti-centromere antibodies in 2 patients with discoid lupus erythematosus and no signs of systemic sclerosis." 12/01/1996 - "Development of squamous cell carcinoma in chronic discoid lupus erythematosus: a report of two patients with anti-Ro/SSA antibodies." Order ALL the reference details at left...
8.	Vitamin E FDA Link 01/01/1979 - "Despite conflicting opinions, our personal experience and a number of reviewed clinical reports indicate that vitamin E, properly administered in adequate doses, is a safe and effective treatment for chronic discoid lupus erythematosus, and may be of value in treating other types of the disease. " 10/01/1992 - "We treated seven patients with discoid lupus erythematosus (DLE) with Vitamin E in an oral dose of 400 mg three times per day for 12 weeks. " 10/01/1992 - "Vitamin E and discoid lupus erythematosus." 11/01/1985 - "Discoid lupus erythematosus: thalidomide or vitamin E?" 07/01/1984 - "Thalidomide or vitamin E therapy for discoid lupus erythematosus?" Order ALL the reference details at left...
9.	Triamcinolone (Aristocort)FDA Link 06/01/1985 - "Intralesional triamcinolone is effective for discoid lupus erythematosus of the palms and soles." 10/01/1962 - "Treatment of chronic discoid lupus erythematosus with intralesional triamcinolone." 07/01/1961 - "Successful skin grating in discoid lupus erythematosus: recurrence checked by triamcinolone ointment (Ledercort)." 01/01/1964 - "CHRONIC DISCOID LUPUS ERYTHEMATOSUS TREATED WITH TRIAMCINOLONE AND PLASTIC OCCLUSION." 10/01/1962 - "Intralesional triamcinolone as an adjunct to antimalarial drugs in the treatment of chronic discoid lupus erythematosus." Order ALL the reference details at left...
10.	Acitretin FDA Link 11/01/2005 - "[Efficacy of acitretin in disseminated discoid lupus erythematosus]" 01/01/2005 - "Rectal bleeding following acitretin therapy for discoid lupus erythematosus." 09/01/2003 - "RESULTS: Patients with various disease, including panniculitis, pityriasis rubra pilaris, eosinophilic fasciitis, discoid lupus erythematosus, and necrobiosis lipoidica diabeticorum, received infliximab infusion at a dose of 5 mg/kg. All patients had refractory disease or adverse effects to previous therapy, which included cyclosporine, systemic steroids, azathioprin, clofazimine, mycophenolate mofetil, acitretin, UVB, and thalidomide. " Order ALL the reference details at left...

Therapies and Procedures

1.	Lasers (Laser) 04/01/2009 - "BACKGROUND: Treatment of chronic discoid lupus erythematosus (CDLE) with a pulsed dye laser (PDL) has shown promising results, although outcomes in previous studies were not validated and laser parameters were inconsistent. " 04/01/1989 - "Laser-Doppler velocimetry was used to quantitate the microvascular flow rates in normal control, disease control (rheumatoid arthritis, discoid lupus erythematosus), and subacute cutaneous lupus erythematosus serum-injected guinea pig skin test sites before and after combined ultraviolet B and A radiation from a solar simulator. " 01/01/2001 - "One case of discoid lupus erythematosus after argon laser has been reported. " 01/01/2000 - "Successful treatment of discoid lupus erythematosus with argon laser." 10/01/1996 - "We report on a patient with chronic discoid lupus erythematosus who was treated with argon-laser. " Order ALL the reference details at left...
2.	Dye Lasers 04/01/2009 - "Efficacy and safety of pulsed dye laser treatment for cutaneous discoid lupus erythematosus." 04/01/2009 - "BACKGROUND: Treatment of chronic discoid lupus erythematosus (CDLE) with a pulsed dye laser (PDL) has shown promising results, although outcomes in previous studies were not validated and laser parameters were inconsistent. " Order ALL the reference details at left...
3.	Transplants (Transplant) 01/01/1976 - "In this study 8 patients with alopecia due to chronic discoid lupus erythematosus (CDLE), 10 patients with traumatic alopecia (TA), and 12 patients with male pattern baldness (MPB) were treated with the punch graft method (PGM). " 01/01/1976 - "The use of hairbearing compound grafts for correction of alopecia due to chronic discoid lupus erythematosus, traumatic alopecia, and male pattern baldness." Order ALL the reference details at left...
4.	Phototherapy (Light Therapy) 03/01/2006 - "A trial of low-dose UVA1 phototherapy for two patients with recalcitrant discoid lupus erythematosus." Order ALL the reference details at left...
5.	Aftercare (After-Treatment) 03/31/1962 - "Corneal deposits and pigmented palate and nails after treatment of chronic discoid lupus erythematosus." 03/01/1952 - "In four cases of chronic discoid lupus erythematosus, although some improvement was observed when steroid therapy was given, the histologic pattern of biopsy material taken from the lesions after treatment still was characteristic of the disease." 10/01/1983 - "Ocular changes after treatment of chronic discoid lupus erythematosus with chloroquine." 03/01/2004 - "We report the case of a patient with rheumatoid arthritis who developed a discoid lupus erythematosus-like eruption after treatment with infliximab. " Order ALL the reference details at left...

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