|1.||Cystic Fibrosis (Mucoviscidosis)
|3.||Asthma (Bronchial Asthma)
|4.||Pulmonary Hypertension (Ayerza Syndrome)
|1.||Koh, Won-Jung: 27 articles (01/2015 - 07/2005)|
|2.||Greene, Catherine M: 18 articles (05/2015 - 07/2003)|
|3.||Griese, Matthias: 18 articles (01/2015 - 06/2002)|
|4.||Halliday, Henry L: 18 articles (01/2014 - 06/2002)|
|5.||Halliday, H L: 18 articles (01/2007 - 01/2000)|
|6.||Mall, Marcus A: 17 articles (12/2015 - 12/2008)|
|7.||Palmer, Scott M: 17 articles (03/2014 - 01/2002)|
|8.||Kwon, O Jung: 17 articles (01/2014 - 07/2005)|
|9.||Blackburn, Michael R: 17 articles (07/2013 - 02/2003)|
|10.||Hayes, Don: 16 articles (01/2016 - 05/2007)|
01/01/1991 - "This study shows that oxygen-assisted exercise training in combination with correction of the nutritional status is safe and beneficial in CF patients with severe lung disease."
12/01/1999 - "Although the frequency of chronic lung disease (oxygen requirement at 36 weeks' postconceptional age) was not significantly different between the groups (p = 0.48), the frequency of infants surviving without chronic lung disease was significantly greater in the steroid-exposed group (p = 0.02). "
06/01/1997 - "To test the hypothesis that the nutrient intake and growth of infants with chronic lung disease would be improved by providing nutrients in more concentrated form, and that the lower volume would improve respiratory status, 60 preterm infants requiring supplemental oxygen at 28 days of age were randomly assigned a low-density (24 kcal/oz) formula fed at 180 ml/kg/day, or a high-density (30 kcal/oz) formula at 145 ml/kg/day. "
12/01/1994 - "Infants with severe respiratory disease requiring high ventilation pressure and high oxygen concentration, where structural changes in the lungs are already established, will rarely show short-term improvement in pulmonary disease as a result of closure of a PDA. "
01/01/1994 - "Patients with lung disease showed a statistically significant improvement at all levels of exercise in the ventilatory equivalent for oxygen. "
|2.||Adrenal Cortex Hormones (Corticosteroids)IBA
01/01/2014 - "Antenatal corticosteroids and surfactant replacement therapy have dramatically reduced mortality caused by lung disease in premature babies. "
03/01/2000 - "During recent years, the treatment of pulmonary diseases could be significantly improved due to the introduction of modern retrometabolism-based corticosteroids with improved therapeutic ratio. "
06/12/2010 - "No subgroup of infants (eg, gestational age, birthweight for gestation, initial lung disease severity, or exposure to antenatal corticosteroids) benefited more or less from HFOV. "
09/01/2012 - "Inhaled corticosteroids are considered to be an effective prophylactic against the morbid symptoms of several lung diseases, but scope remains for improvement in drug delivery technology to benefit bioavailability and treatment compliance. "
01/01/2009 - "Postnatal corticosteroids are effective in preventing chronic lung disease in preterm infant. "
|3.||Dexamethasone (Maxidex)FDA LinkGeneric
09/01/1999 - "We performed a systematic review of randomized controlled trials to determine whether the use of dexamethasone therapy in the first 15 days of life is beneficial for prevention of chronic lung disease is prematurely born infants. "
03/01/2005 - "A 42-day course of dexamethasone therapy beginning at 2 weeks of age in preterm infants who are at high risk for severe chronic lung disease was associated with improved long-term neurodevelopmental outcome. "
02/01/1988 - "Six of the seven infants were extubated within 12 days of commencing the dexamethasone, whilst the remaining infant continued to need respiratory support for apnoea, despite significant improvement in the pulmonary disease. "
07/01/2008 - "Subgroup analysis of the studies contrasting dexamethasone doses in the higher ranges showed that the higher dose of dexamethasone was more effective in reducing the occurrence of chronic lung disease than was the lower dose. "
04/01/2002 - "Dexamethasone is widely used for the treatment of chronic lung disease (CLD), but its mechanism of action is still not clearly understood. "
|4.||Nitric Oxide (Nitrogen Monoxide)FDA Link
01/01/2002 - "Safety and efficacy of nitric oxide in chronic lung disease."
05/01/1999 - "Sixteen patients (62%) responded to inhaled nitric oxide with a > or =15% improvement in PaO2; 14 of these responses occurred at a dose of 1 or 5 ppm. Response to inhaled nitric oxide was not associated with age, length of intubation, presence of primary lung disease, chest radiograph, or illness severity. "
03/01/1999 - "Inhaled nitric oxide: a premature remedy for chronic lung disease?"
11/05/1997 - "Pulmonary vascular resistance and systemic oxygenation are acutely improved by 10 ppm inhaled nitric oxide in some children with severe lung disease. "
02/01/1996 - "Pulmonary vascular resistance and systemic oxygenation are acutely improved to a similar extent by 11 and 60 ppm inhaled nitric oxide, and concentrations in excess of 10 ppm are probably not needed for prolonged therapy of children with severe lung disease."
|5.||Clarithromycin (Biaxin)FDA LinkGeneric
02/01/2002 - "Even in the present clarithromycin era, pulmonary resection remains the treatment of choice when MAC lung disease has not been successfully eradicated by drug treatment alone."
03/01/2011 - "The efficacy of a clarithromycin-containing regimen for MAC pulmonary disease was studied in 42 patients treated for more than 6 months between January 2005 and December 2008. "
03/01/2011 - "The combined regimen including clarithromycin was effective against MAC pulmonary disease. "
10/01/2004 - "We retrospectively investigated the efficacy of regimens including clarithromycin (CAM) in 129 patients with Mycobacterium avium complex (MAC) pulmonary disease and their outcomes. "
11/01/2003 - "We initiated a prospective trial of an intermittent clarithromycin-containing regimen for the treatment of patients with Mycobacterium kansasii lung disease. "
|6.||Anti-Bacterial Agents (Antibiotics)IBA
06/01/2015 - "IPFT and CV-HRCT can be used as objective measures of improvement in lung disease for infants with CF treated with antibiotics."
10/01/2015 - "This study aimed to provide basic pharmacodynamic information for key antibiotics used to treat Mycobacterium avium and Mycobacterium xenopi pulmonary disease. "
01/01/2014 - "The aim of the present study was to investigate whether alterations in serum immunomolecule levels after treating MABC lung disease patients with antibiotics can reflect the disease-associated characteristics. "
09/01/2003 - "The aim of this study was to assess whether FENO is a useful non-invasive marker of lung disease in CF by assessing the effect of intravenous (IV) antibiotics on FENO. "
05/01/1998 - "This data may be useful when designing prophylactic or therapeutic trials of antibiotics for chronic lung disease of the newborn."
09/01/2000 - "Fluid restriction has been reported to improve survival of infants without chronic lung disease (CLD), but it remains unknown whether it reduces CLD in a population at high risk of CLD routinely exposed to antenatal steroids and postnatal surfactant without increasing other adverse outcomes. "
03/01/2004 - "There are numerous clinical studies on the therapeutic use of these steroids for the prevention of respiratory distress syndrome and chronic lung disease in the premature infant, although research results on the efficacy of repeated steroid exposure among premature infants vary. "
01/01/2012 - "Although the early trials of prophylactic surfactant administration to infants judged to be at risk of developing RDS compared to selective use of surfactant in infants with established RDS demonstrated a decreased risk of air leak and mortality, recent large trials that reflect current practice (including greater utilization of maternal steroids and routine post delivery stabilization on CPAP) do not support these differences and demonstrate less risk of chronic lung disease or death when using early stabilization on CPAP with selective surfactant administration to infants requiring intubation."
01/01/2010 - "Only randomised controlled trials involving infants with chronic lung disease of prematurity and treated with inhaled steroids versus placebo were included. "
01/01/2000 - "Only randomised controlled trials involving infants with chronic lung disease of prematurity and treated with inhaled steroids versus placebo were included. "
|8.||Cyclophosphamide (Cytoxan)FDA LinkGeneric
11/01/2006 - "We conclude that although the study provides an excellent starting point for examining the efficacy of cyclophosphamide in certain forms of scleroderma lung disease, the study's high drop-out rate, choice of forced vital capacity as a primary outcome, side-effect profile of the drug and overall significance of the results make the conclusions difficult to incorporate into clinical practice."
11/01/1998 - "Until a placebo-controlled study of any drug has shown its beneficial effect on pulmonary dysfunction, cyclophosphamide may be useful for the treatment of scleroderma lung disease."
09/01/2005 - "To determine whether cyclophosphamide is beneficial for patients with scleroderma lung disease (SLD). "
05/01/2007 - "Impact of oral cyclophosphamide on health-related quality of life in patients with active scleroderma lung disease: results from the scleroderma lung study."
02/01/2007 - "The purpose of the study was to examine prospectively the efficacy and safety of the combination of intravenous pulses of cyclophosphamide and methylprednizolone, in the treatment of scleroderma lung disease. "
|9.||Azithromycin (Zithromax)FDA LinkGeneric
01/01/2008 - "Long-term, low-dose azithromycin has been shown to improve clinical outcomes in chronic lung diseases, although the mechanism of action remains unclear. "
01/01/2014 - "Randomized controlled trials that enrolled patients with chronic lung diseases who received long-term azithromycin treatment were selected, and data on microbiological studies and azithromycin-related adverse events were abstracted from articles and analyzed. "
01/01/2014 - "The adverse effects of azithromycin on the treatment of patients with chronic lung diseases (CLD) were evaluated in the present study. "
01/01/2004 - "Further studies are needed to clarify the precise role of azithromycin in the treatment of CF lung disease."
07/01/1998 - "Two consecutive, open, prospective trials of intermittent azithromycin (600 mg), usually given Monday, Wednesday, and Friday (TIW) for Mycobacterium avium complex (MAC) lung disease were initiated in human immunodeficiency virus-negative patients. "
|10.||Idiopathic pulmonary hypertensionIBA
10/03/2013 - "It is not known whether specific treatment with existent drugs effective in pulmonary arterial hypertension (PAH) is beneficial in lung disease related PH. Studies investigating existing PAH drugs in animal models of lung disease related PH have indicated a positive effect, and so have case reports and open label studies. "
07/01/2014 - "ET receptor antagonists (ERA) demonstrated beneficial effects in many different pre-clinical models of cardiovascular and pulmonary diseases, and constitute a first-line treatment of patients with pulmonary arterial hypertension (PAH). "
12/01/2011 - "These cells provide an alternative model for relevant lung research and hold promise in particular for studying the initiation of disease processes in genetic conditions such as heritable pulmonary arterial hypertension as well as other lung diseases. "
07/01/1989 - "Non-invasive assessment of pulmonary arterial hypertension in chronic lung disease (WHO study)."
01/01/1984 - "Evaluation problems of a long-term study on evolving pulmonary arterial hypertension in chronic non specific lung disease."
11/01/2012 - "Lung transplantation has come to be viewed as the best treatment option for various end-stage lung diseases. "
06/01/2012 - "Lung transplantation (LTx) remains the best option for selected patients with end-stage lung disease. "
12/01/2010 - "Lung transplantation remains the best treatment option for a variety of end-stage lung diseases. "
10/01/2005 - "Lung transplantation is effective for end-stage pulmonary disease, but its successful application is still limited by organ shortage and sub-optimal preservation techniques. "
08/01/2003 - "Lung transplantation usually provides prolongation and marked improvement in quality of life in patients who would otherwise die from end-stage pulmonary disease. "
|2.||Drug Therapy (Chemotherapy)
09/01/2005 - "[A case of Mycobacterium intracellulare lung disease that was detected by health examination and was successfully cured by chemotherapy--including discussions on the diagnostic criteria of the disease]."
01/01/2008 - "malmoense infectious lung disease which could be cured by surgical operation without chemotherapy. "
01/01/2003 - "To assess the efficacy of antituberculous drug therapy against MAC pulmonary disease using computed tomography (CT). "
10/01/1998 - "We evaluated the efficacy of local chemotherapy using isolated lung perfusion (ILP) and pulmonary artery infusion (PAI) in vivo to improve prognosis for patients with metastatic lung diseases. "
07/01/2000 - "[A study on the effect of combined chemotherapy on Mycobacterium avium complex pulmonary disease]."
06/01/2011 - "Lung transplant offers the hope of prolonged survival and significant improvement in quality of life to patients with advanced lung disease. "
01/01/2014 - "More precise characterization of stem cells with identification of new, unique markers; improvement in isolation and transplant techniques; and further development of functional assays will ultimately lead to new therapies for a host of human lung diseases. "
01/01/2002 - "Whereas lung or heart-lung transplant for PHT is associated with higher early mortality than other pulmonary disease entities, it provides similar long-term outcomes with dramatic improvement in both quality of life and physiologic aspects."
02/01/2010 - "Lung transplant is an effective treatment for patients with end-stage lung disease but is limited because of the shortage of acceptable donor organs. "
06/01/2010 - "Individuals with CF and end stage lung disease have improved survival after lung transplant. "
|4.||Mechanical Ventilators (Ventilator)
01/01/1997 - "Although high-frequency ventilators (HFV) may be less effective in patients with lung diseases complicated by high airway resistance, such as BPD, high-frequency oscillatory ventilators (HFOV) can still provide an alternative treatment of choice due to its property of active exhalation, in addition to its tidal volume being less than dead space and its minute ventilation being more dependent on tidal volume. "
01/01/2002 - "In this study, 20 patients with severe lung disease requiring ventilator support, were recruited. "
04/01/2000 - "Postnatal corticosteroid therapy has been proved in randomized controlled trials to reduce ventilator dependence and the rate of chronic lung disease in preterm infants with few serious short-term side effects. "
03/01/1986 - "Few studies have examined the response of individuals with restrictive lung disease (RLD) to respirator wear. "
12/01/2015 - "Electrical impedance tomography (EIT) has the potential to become a bedside tool for monitoring and guiding ventilator therapy as well as tracking the development of chronic lung diseases. "
|5.||Artificial Respiration (Mechanical Ventilation)
03/01/1987 - "These results indicate that in infants with chronic lung disease after mechanical ventilation, lung volume increases normally, probably by formation of new alveoli, which also leads to improvement in lung compliance. "
09/01/2009 - "Clinical trials have shown that CPAP reduces the need for intubation/mechanical ventilation and surfactant administration, but it is still unclear whether CPAP reduces chronic lung disease and mortality, compared to modern lung-protective ventilation techniques. "
05/01/2005 - "Twelve children between 7 and 65 months of age, requiring mechanical ventilation as a consequence of a non-pulmonary disease, were enrolled in the study. "
09/01/1998 - "Recent studies showed the possible positive effect of body position changes during mechanical ventilation of severe lung diseases in adult patients. "
12/01/1992 - "Two different ventilation techniques were compared in a seven-centre, randomised trial with 181 preterm infants up to and including 32 completed weeks gestational age, who needed mechanical ventilation because of lung disease of any type. "