HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Lovastatin (Mevacor)

A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.
Also Known As:
Mevacor; 6-Methylcompactin; Lovastatin, (1 alpha(S*))-Isomer; MK-803; Monacolin K; 1 alpha-Isomer Lovastatin; 6 Methylcompactin; Lovastatin, 1 alpha Isomer; MK 803; MK803; alpha-Isomer Lovastatin, 1; Lovastatin, 1 alpha-Isomer; Mevinolin; Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))-
Networked: 1545 relevant articles (177 outcomes, 354 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1. Singh, Inderjit: 16 articles (01/2018 - 11/2002)
2. Singh, Avtar K: 11 articles (01/2018 - 11/2002)
3. Dimitroulakos, Jim: 11 articles (01/2014 - 07/2002)
4. Pan, Tzu-Ming: 11 articles (12/2013 - 01/2003)
5. Deng, Xiyun: 8 articles (01/2022 - 01/2016)
6. Paintlia, Ajaib S: 8 articles (09/2013 - 10/2004)
7. He, Guangchun: 7 articles (01/2022 - 01/2016)
8. Fritz, Gerhard: 7 articles (01/2018 - 10/2002)
9. Paintlia, Manjeet K: 7 articles (09/2013 - 10/2004)
10. Jakóbisiak, Marek: 7 articles (01/2008 - 02/2002)

Related Diseases

1. Hypercholesterolemia
2. Hyperlipoproteinemia Type II (Familial Hypercholesterolemia)
3. Neoplasms (Cancer)
4. Hyperlipidemias (Hyperlipidemia)
5. Dyslipidemias (Dyslipidemia)

Related Drugs and Biologics

1. Cholesterol
2. Lipids
3. Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)
4. Simvastatin (Zocor)
5. Pravastatin (Pravachol)
6. LDL Cholesterol
7. Atorvastatin (Lipitor)
8. Fluvastatin
9. Gemfibrozil (Lopid)
10. Colestipol (Colestid)

Related Therapies and Procedures

1. Therapeutics
2. Secondary Prevention
3. Drug Therapy (Chemotherapy)
4. Cardiopulmonary Resuscitation (CPR)
5. Heart Transplantation (Grafting, Heart)