Loperamide (Imodium)

One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.

Also Known As:

Networked: 920 relevant articles (126 outcomes, 132 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Hwang, Dae Youn: 16 articles (01/2022 - 11/2013)
2.	Kim, Ji Eun: 16 articles (01/2022 - 11/2013)
3.	Hong, Jin Tae: 11 articles (01/2022 - 11/2013)
4.	Sebai, Hichem: 8 articles (09/2022 - 01/2017)
5.	Chen, Wei: 7 articles (05/2022 - 02/2017)
6.	Wang, Gang: 7 articles (05/2022 - 02/2017)
7.	Wang, Linlin: 7 articles (05/2022 - 02/2017)
8.	Zhang, Hao: 7 articles (05/2022 - 02/2017)
9.	Zhao, Jianxin: 7 articles (05/2022 - 02/2017)
10.	Suh, Hyung Joo: 7 articles (05/2021 - 12/2016)

Related Diseases

1.	Diarrhea 02/01/1996 - "Loperamide was considered the most effective agent for controlling delayed diarrhea. " 03/01/1984 - "Most symptoms improved significantly on placebo compared with the baseline period, but three of these [diarrhea (P less than 0.01), urgency (P less than 0.01) and borborygmi (P less than 0.05)] showed a further significant improvement on loperamide. " 06/01/2005 - "Imodium is more effective than placebo at improving stool consistency and decreasing stool frequency in patients with IBS, and it may be an important component for treating diarrhea-predominant IBS. " 04/01/2013 - "There is a lack of significant studies which investigate the efficacy of loperamide in the symptomatic treatment of diarrhea. " 01/01/2022 - "guineense fruit pulp at 1000, 2000, and 4000 mg/kg administered before the induction of diarrhea, has significantly delayed diarrhea; reduced the frequency of defecation, reduced the amount of diarrheal stools, and also reduced the purging index, with a degree of inhibition comparable to that of loperamide. "
2.	Constipation 01/01/2023 - "(2) While Loperamide induced slow transit constipation with a significant reduction in fecal pellet number and feces wet weight, daily SNS for a week resolved constipation. " 12/01/2022 - "Loperamide treatment induced animal constipation and significantly reduced the frequency of defecation, intestinal transit ratio, and water content of feces. " 11/20/2023 - "In this study, we selected ten strains of two species of lactobacilli to identify whether they were effective against constipation induced by loperamide administration in BALB/c mice. " 11/15/2022 - "The present study was undertaken to assess SHTC relieved effects on the clinical symptoms of loperamide (LOP) induced constipation in Sprague Dawley (SD) rat model and to clarify the relationship between the protective effect of SHTC on constipation and the gut microbiota. " 01/15/2022 - "This study determined the protective effects of BSH-1 against loperamide (Lop)-induced constipation in mice. "
3.	Pain (Aches) 11/01/2014 - "The study demonstrates that topically applied loperamide encapsulated within liposomal systems has improved therapeutic efficacy over conventional formulations for the local treatment of acute peripheral inflammatory pain conditions where the skin has remained intact. " 08/01/2003 - "Loperamide is effective treatment for urgency and loose stools, but less effective for bloating and pain. " 05/01/1996 - "Throughout the 5 weeks of treatment an improved stool consistency (32%), reduced defecation frequency (36%), and reduced intensity of pain (30%) were found in the loperamide group. " 07/21/2009 - "Clinical studies have shown that it is just as effective as loperamide in resolving acute diarrhoea but with greater reduction in pain and abdominal distension. " 05/01/1996 - "An increase in nightly pain was observed in the loperamide group. "
4.	Dysbiosis 11/11/2023 - "Our results demonstrate that loperamide, in addition to host effects, also induces dysbiosis in a vertebrate model, highlighting that established treatments can have underlooked secondary effects on microbiota structure and function. " 11/11/2023 - "This dysbiosis is due to changes in bacterial colonization, since gnotobiotic zebrafish mono-colonized with bacterial strains sensitive to loperamide are colonized up to 100-fold lower when treated with loperamide. " 11/11/2023 - "Anti-diarrheal drug loperamide induces dysbiosis in zebrafish microbiota via bacterial inhibition." 04/25/2018 - "Manipulation of intestinal dysbiosis by a bacterial mixture ameliorates loperamide-induced constipation in rats." 01/01/2022 - "Interestingly, CCAE could also partially restore loperamide-induced gut microbial dysbiosis in various aspects, such as microbial diversity, community structure and species composition. "
5.	Irritable Bowel Syndrome (Syndrome, Irritable Bowel) 05/01/1996 - "A double-blind placebo-controlled trial with loperamide in irritable bowel syndrome." 01/01/1987 - "The effect of loperamide was investigated in a double-blind, placebo-controlled study in 60 patients with irritable bowel syndrome (IBS). " 01/01/1987 - "Loperamide in treatment of irritable bowel syndrome--a double-blind placebo controlled study." 03/01/1984 - "Symptom scores, stool data, and the transit of a standard, solid meal were measured in 28 patients with irritable bowel syndrome (IBS) during baseline conditions and after five weeks of treatment with placebo and loperamide, given as a flexible dosage regime in the form of a double-blind, cross-over trial. " 01/01/1987 - "Loperamide treatment of the irritable bowel syndrome."

Related Drugs and Biologics

1.	Octreotide (Sandostatin)
2.	Ciprofloxacin (Cipro)
3.	Castor Oil (Oil, Castor)
4.	Opioid Receptors (Opioid Receptor)
5.	Loperamide (Imodium)
6.	Antidiarrheals
7.	Diphenoxylate
8.	Atropine
9.	bismuth subsalicylate (Pepto-bismol)
10.	Azithromycin (Zithromax)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Psychology Biofeedback (Biofeedback)
4.	Analgesia
5.	Enema (Enemas)