Long-Acting Thyroid Stimulator (LATS)

An immunoglobulin G, often found in the blood of hyperthyroid individuals. It stimulates the thyroid for a longer duration than does thyrotoxin and may cause hyperthyroidism in newborns due to placental transmission.

Also Known As:

LATS; Antibody, Thyrotropin Receptor; Autoantibody, Thyrotropin Receptor; Long Acting Thyroid Stimulator; Receptor Antibody, Thyrotropin; Receptor Autoantibody, Thyrotropin; Thyroid Stimulator, Long Acting; Thyroid Stimulating Hormone Receptor Autoantibodies; Thyroid Stimulating Hormone Receptor Autoantibody; Thyroid Stimulator, Long-Acting; Thyrotropin Receptor Antibodies; Thyrotropin Receptor Antibody; Thyrotropin Receptor Autoantibodies; Thyrotropin Receptor Autoantibody

Networked: 689 relevant articles (10 outcomes, 56 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Yang, Xiaolong: 8 articles (01/2022 - 02/2008)
2.	Kahaly, George J: 8 articles (01/2021 - 08/2010)
3.	Hayashi, Kazuhiko: 8 articles (11/2020 - 05/2014)
4.	Nagata, Keiko: 8 articles (11/2020 - 05/2014)
5.	Guan, Kun-Liang: 7 articles (10/2022 - 11/2007)
6.	Kato, Masako: 7 articles (11/2019 - 05/2014)
7.	Kuwamoto, Satoshi: 7 articles (11/2019 - 05/2014)
8.	Matsushita, Michiko: 7 articles (11/2019 - 05/2014)
9.	Hergovich, Alexander: 7 articles (10/2019 - 07/2009)
10.	Diana, Tanja: 6 articles (01/2021 - 01/2019)

Related Diseases

1.	Graves Disease (Basedow Disease) 09/01/1989 - "Increased activated T-lymphocytes and normal thyrotropin receptor antibody levels in Graves' disease in long-term remission." 09/30/2023 - "In this study, we explored the expression of the functional TSHR in Graves' disease (GD) mouse cerebral vascular endothelial cells and the effects of thyrotropin receptor autoantibody (TRAb) on its expression. " 01/01/2020 - "Prospective Trial of Functional Thyrotropin Receptor Antibodies in Graves Disease." 07/01/2000 - "The goal of this study was to evaluate the clinical significance of the blocking thyrotropin receptor antibodies (TSHRAb) in Graves' disease. " 07/01/1996 - "The purpose of this study was to evaluate the sensitivity, specificity and predictive value of thyrotropin receptor antibody (TRAb) in the diagnosis of Graves disease. "
2.	Hyperthyroidism 05/01/2000 - "Bioassay of thyrotropin receptor antibodies may help to determine the risk for neonatal hyperthyroidism. " 01/01/2020 - "Diagnostic testing for Graves' or non-Graves' hyperthyroidism: A comparison of two thyrotropin receptor antibody immunoassays with thyroid scintigraphy and ultrasonography." 01/01/2019 - "Measurement of serum thyrotropin receptor antibodies identifies pregnancies at-risk for fetal and neonatal hyperthyroidism." 01/01/2016 - "Thyroid function tests indicated biochemical hyperthyroidism, and thyrotropin receptor antibodies were positive. " 09/01/2015 - "Thyroid-stimulating hormone-receptor autoantibodies normally causes hyperthyroidism. "
3.	Hypothyroidism 01/01/2019 - "Therefore, LATS now recommends aggressive case finding of hypothyroidism in both MetS and T2DM patients. " 01/01/2019 - "Hence, the aim of this review is to manifest the LATS position on the diagnosis of hypothyroidism in both MetS and T2DM patients. " 01/01/2019 - "Latin American Thyroid Society (LATS) Hypothyroidism Clinical Practice Guidelines recommend case finding of hypothyroid patients in multiple and different situations that agree with other Society guidelines. " 11/01/1990 - "Low prevalence of thyrotropin receptor antibody in primary hypothyroidism in Japan." 12/01/1980 - "Mild hypothyroidism occurred transiently without any significant change in serum LATS activity. "
4.	Neoplasm Metastasis (Metastasis) 01/01/2023 - "In conclusion, SREBP2 enhances the invasion and metastasis of HCC cells by promoting EMT, which can be strengthened by the repression of LATS. " 11/01/2013 - "Both the ATA and LATS risk stratification systems provided clinically meaningful graded estimates with regard to (i) the likelihood of achieving remission in response to initial therapy, (ii) the likelihood of having persistent structural disease in response to initial therapy and at final follow-up, (iii) the likely locations of the persistent structural disease (locoregional vs. distant metastases), (iv) the likelihood of recurrence, and (v) the likelihood of being no evidence of disease at final follow-up. " 01/01/2017 - "To investigate the role of intraoperative local ablation techniques (LATs) in bilobar colorectal liver metastases (bCRLM). " 12/16/2019 - "Malignant LATs accounted for 28.69% of cases, mainly including adrenocortical carcinoma (8.76%) and metastases (17.13%). " 01/01/2021 - "After a random-case control matching according to ECOG-PS, CNS metastases, bone metastases, and (previous) best response to pembrolizumab, patients receiving pembrolizumab ByPD plus LATs were confirmed to have a significantly longer post-progression OS compared to patients receiving pembrolizumab ByPD alone 13.9 months versus 7.8 months (p = 0.0179) 241 patients (35.5%) among the 678 who had experienced PD, received a second-line systemic treatment (regardless of previous treatment beyond PD). "
5.	Intervertebral Disc Degeneration 01/01/2022 - "Irisin Ameliorates Intervertebral Disc Degeneration by Activating LATS/YAP/CTGF Signaling." 10/01/2021 - "In conclusion, DNP-G and DAF-G can specifically determine the fate of stem cells through the integrin-mediated RhoA/LATS/YAP1 signaling pathway, and this tissue specificity is both compositional and spatial, supporting the utilization of tissue-specific DTM in advanced treatments of intervertebral disc degeneration."

Related Drugs and Biologics

1.	Thyrotropin (Thyroid-Stimulating Hormone)
2.	Thyroxine (Levothyroxine)
3.	Iodide Peroxidase (Deiodinase)
4.	Methimazole (Thiamazole)
5.	Carbimazole
6.	Antigen-Antibody Complex (Immune Complex)
7.	Propranolol (Inderal)
8.	HLA-DR Antigens (HLA-DR)
9.	N 30
10.	Long-Acting Thyroid Stimulator (LATS)

Related Therapies and Procedures

1.	Therapeutics
2.	Thyroidectomy
3.	Drug Therapy (Chemotherapy)
4.	Aftercare (After-Treatment)
5.	Ablation Techniques