Liver Diseases (Liver Disease)

02/01/1994 - "Ursodeoxycholic acid has been reported to be beneficial for patients with various chronic cholestatic liver diseases"
01/01/1994 - "BACKGROUND/AIMS: Ursodeoxycholic acid (UDCA) is clinically beneficial in chronic cholestatic liver disease, but the underlying mechanisms are unclear"
02/01/2004 - "Ursodeoxycholic acid (UDCA) is widely used for the treatment of cholestatic liver diseases"
02/01/2004 - "Mechanisms of action and therapeutic efficacy of ursodeoxycholic acid in cholestatic liver disease."
09/24/1999 - "The therapeutic efficacy of ursodeoxycholic acid (UDCA) has been widely demonstrated in various liver diseases, suggesting that UDCA might protect hepatocytes against common mechanisms of liver damage"
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01/01/2001 - "The short courses of interferon monotherapy that were used in the early 1990s led to sustained improvement in liver disease and durable loss of detectable virus in fewer than 10% of patients"
02/01/2000 - "Interferon monotherapy became clinically available 10 years ago but resulted in sustained improvement in liver disease and durable loss of detectable virus in fewer than 10% of treated patients"
11/01/1995 - "Thus, longterm interferon treatment seems effective in clearing hepatitis C virus from serum of patients with chronic liver disease."
01/01/1990 - "These results indicate that interferon is effective in inducing clearance of HBV from serum and improvement of biochemical and histological parameters of liver disease"
09/01/2003 - "In the absence of suitable animal models, HCV dynamic studies in man have been helpful in defining the mechanisms of action of interferon in chronic HCV liver disease"
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01/01/1995 - "We now show that the number of amino acid substitutions in the HBV core is low in viral sequences from patients with HBeAg positive chronic liver disease and HBeAg negative HBeAb positive patients in remission, but the frequency of substitutions is high in HBeAg, negative HBeAb positive patients with active liver disease"
09/01/2006 - "Courses of finite duration, aiming to achieve sustained off-therapy responses, are practically restricted to HBeAg+ patients with compensated chronic liver disease, whereas long-term therapy aiming to achieve maintained on-therapy remission is mostly applicable to HBeAg- individuals either with early or advanced liver disease"
07/01/1996 - "Conversely about 90% of children infected later in life clear HBeAg and achieve sustained remission of liver disease before reaching adulthood"
03/01/2007 - "These will be followed eventually by HBeAg seroconversion, which is usually accompanied by remission of liver disease and confers favourable outcome"
01/01/1979 - "In all but one, progression of the liver disease stopped when HBeAg was cleared"
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08/01/2000 - "A significant reduction was noted in the morbidity and hospitalizations for complications of liver disease before and after starting lamivudine (1.5+/-0.7 vs. 0.6+/-0.7, p<0.002)"
07/01/2000 - "Liver disease-significant improvement with lamivudine."
11/01/2002 - "Lamivudine has previously been found to be effective not only in patients with compensated liver disease due to hepatitis B virus (HBV) but also in those with hepatic decompensation"
01/01/2008 - "However, liver dysfunction was not improved by lamivudine"
01/01/2008 - "Lamivudine has been suggested to be useful as a prophylaxis for HBV reactivation; however, its impact on overall survival and HBV reactivation-related liver disease survival is unclear"
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07/01/1990 - "All 21 cleared the antigen during follow-up and liver disease was either mild and asymptomatic (nine cases) or clinically overt (12 cases), but none had life-threatening liver disease"
03/01/1993 - "Blast cells with Auer rods demonstrated 8;21 translocation lacking 11q with 30 of 30 analyzed bone marrow cells, and the following antigen pattern: CD5+, CD19+, CD33+, CD56+, HLA-DR+. After 4 courses of post remission therapy, the maintenance therapy was discontinued because of his liver dysfunction"
04/01/1988 - "In several liver diseases qualitative and quantitative changes in the HLA gene product expression can be found on hepatocytes, bile duct epithelium and sinusoidal lining cells and these changes may affect the efficacy of the immune system in recognizing an exogenous antigen"
05/01/1985 - "We postulate that, in patients with liver disease either increased intestinal uptake resulting in increased humoral response, or decreased hepatic clearance of food antigens intensifying a humoral response to these foreign antigens, may occur."
12/01/1976 - "While persistence of the antigenaemia is associated with persisting liver disease, the converse is not true in that the disappearance of the antigen does not necessarily imply an improvement in liver disease"
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05/01/1997 - "The results show that in general, the branched DNA assay detects HBV DNA in more patients than hybrid-capture and that this improved detection rate is relevant clinically and genome equivalents/ml are preferred to pg/ml to quantify HBV DNA in clinical specimens and finally qualitative, non-quantitative polymerase chain reaction can detect HBV DNA in patients without evidence of active HBV-related liver disease"
07/01/2000 - "No TTV infected child [follow-up: 31 (median; range: 6-60) months] showed signs of liver disease; five infants cleared TTV DNA after 22 (median; range: 6-60) months"
04/01/1999 - "Advances in computer-aided diagnosis, imaging techniques, DNA mutation analysis, virology, immunology and biochemistry have improved our understanding of chronic liver diseases and the possibilities for non-invasive diagnosis"
11/01/1998 - "Two patients cleared HBV DNA, and their liver disease improved by clinical and histologic criteria"
11/27/1996 - "Our aim was to test its efficacy when used pre- and posttransplantation in HBV-DNA positive patients with endstage liver disease"
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05/01/1992 - "Although the frequency of HBsAg loss in treated patients is relatively low, the improvement in liver disease obtained from IFN therapy is sustained over a long period."
03/01/2006 - "Patients who on follow-up cleared HBsAg and/or did not develop any clinical, radiologic, or histologic evidence of chronic liver disease (CLD) were categorized as AVHB (group 1)"
09/01/2005 - "The purpose of the present study was to determine the frequency of hepatitis B virus (HBV) markers in families of HBsAg-positive patients with chronic liver disease"
04/01/2005 - "STUDY DESIGN: Prospective study of 70 consecutive patients with features of early liver disease or discovered with HBsAg (or anti-HCV) during pre-employment and/ or pre-donation screening at Ile-Ife, Nigeria"
01/01/2002 - "BACKGROUND: The aim of the present study was to evaluate the clinical characteristics at first hospital consultation, according to the genotype of hepatitis B virus (HBV), in patients with chronic liver diseases and positivity for hepatitis B surface antigen (HBsAg) in metropolitan Tokyo"
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04/01/1996 - "Efficacy of low-dose alpha interferon therapy in HBV-related chronic liver disease in Asian Indians: a randomized controlled trial."
01/01/1996 - "Efficacy of human leukocyte interferon-alpha treatment in elderly patients with hepatitis-C virus-related chronic liver disease."
03/01/1994 - "Treatment with alfa-interferon (alpha IFN) was added and thereafter, the liver dysfunction improved"
07/07/2005 - "AIM: To study the expression of interferon-alpha/beta (IFN-alpha/beta) receptor protein in liver of patients with hepatitis C virus (HCV)-related chronic liver disease and its clinical significance"
11/01/1998 - "In addition, 120 consecutive patients with chronic liver diseases (disease control group), who had never received alpha-interferon therapy, were evaluated during the period of the study (at least for 12 months)"
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06/01/1981 - "Clinical features of liver disease on entry into the study were similar in the two groups, and total serum bilirubin and prothrombin time improved more rapidly in the treatment group (p less than 0.05)"
01/01/1983 - "Treatment for cholestatic liver disease (CLD): plasma sorption and filtration for improved bilirubin removal."
01/01/1974 - "Hepatic clearance of unconjugated bilirubin in cholestatic liver diseases."
05/01/2008 - "In the present study, we report a confirmed case of a girl of 1 year of age with increased bilirubin of 28.5 mg/dL and pediatric end-stage liver disease score 20"
03/01/1999 - "This study was conducted to identify bilirubin in deciduous teeth obtained from two patients with a history of severe liver dysfunction"
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