Experimental Liver Cirrhosis

Experimentally induced chronic injuries to the parenchymal cells in the liver to achieve a model for LIVER CIRRHOSIS.

Also Known As:

Liver Cirrhosis, Experimental; Cirrhoses, Experimental Liver; Cirrhosis, Experimental Liver; Experimental Liver Cirrhoses; Liver Cirrhoses, Experimental; Experimental Hepatic Cirrhosis; Hepatic Cirrhosis, Experimental

Networked: 140 relevant articles (1 outcomes, 22 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Liver Cirrhosis (Hepatic Cirrhosis)
2.	Fibrosis (Cirrhosis)
3.	Neoplasms (Cancer)
4.	Inflammation (Inflammations)
5.	Portal Hypertension

Experts

1.	Armendariz-Borunda, Juan: 2 articles (11/2006 - 10/2006)
2.	Bogahawaththa, Sudarma: 1 article (08/2021)
3.	Dissanayaka, Waruna L: 1 article (08/2021)
4.	Herath, Chandana B: 1 article (08/2021)
5.	Jayasinghe, Lalith: 1 article (08/2021)
6.	Kodithuwakku, Suranga P: 1 article (08/2021)
7.	Rajapakse, Jayanthe: 1 article (08/2021)
8.	Siriweera, Eranga H: 1 article (08/2021)
9.	Tsujita, Tadayuki: 1 article (08/2021)
10.	Wijayagunawardane, Missaka P B: 1 article (08/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Experimental Liver Cirrhosis:

1.	FP 736-04IBA 09/01/1998 - "The efficacy of FP 736-04 in experimental liver cirrhosis."
2.	Thioacetamide (Thioacetamid)IBA 03/01/2015 - "The current study was undertaken to evaluate the protective activity of olive and rosemary leaves extracts on experimental liver cirrhosis induced by thioacetamide (TAA) in Wistar male rats. " 01/01/1991 - "Gamma-glutamyltranspeptidase (GGT) in experimental liver cirrhosis induced by thioacetamide: a biochemical and enzymehistochemical study." 01/01/1987 - "Biochemical and morphological studies on production and regression of experimental liver cirrhosis induced by thioacetamide in Uje: WIST rats." 08/10/2021 - "Anti-Fibrotic and Anti-Angiogenic Activities of Osbeckia octandra Leaf Extracts in Thioacetamide-Induced Experimental Liver Cirrhosis." 03/01/1997 - "Experimental liver cirrhosis was produced by administration of thioacetamide. "
3.	Messenger RNA (mRNA)IBA 01/01/2011 - "In the present study, the influence of liver cirrhosis on pharmacokinetics of Pd-Ia and hepatic mRNA expression of CYP3A1 and 3A2 in rats with experimental liver cirrhosis (LC rats) were evaluated. " 03/29/2002 - "Studies of experimental liver cirrhosis demonstrated that persistent expression of TIMP-1 mRNA determined by PCR correlated with persistence of activated HSC quantified by alpha smooth muscle actin staining, while in fibrosis, loss of activated HSC correlated with a reduction in TIMP-1 mRNA. "
4.	Carbon Tetrachloride (Tetrachloromethane)IBA 08/01/2018 - "The objective was to evaluate the effect of MLT on experimental liver cirrhosis induced by carbon tetrachloride (CCl4) in rats. " 09/01/1962 - "[Morphological and functional phases of development of experimental liver cirrhosis under the influence of carbon tetrachloride]." 08/01/2012 - "To present a review about a comparative study of bile duct ligation versus carbon tetrachloride Injection for inducing experimental liver cirrhosis. " 03/15/1958 - "[Effect of splenectomy on experimental liver cirrhosis induced by carbon tetrachloride]." 09/01/1988 - "Experimental liver cirrhosis was induced by subcutaneous injections of 50% carbon tetrachloride in a dose of 2 mL/kg body weight twice a week for 16 weeks. "
5.	SodiumIBA 06/01/1991 - "It is proposed that Na(+)-CSF infusion may be a useful tool for the study of renal sodium retention in experimental liver cirrhosis." 07/01/2007 - "Renal sodium retention in experimental liver cirrhosis originates from the distal nephron sensitive to aldosterone. " 01/01/1995 - "Rats with experimental liver cirrhosis have increased endothelin-1 (ET-1) plasma concentrations and show a tendency toward sodium and water retention. " 12/01/1990 - "Changes in the major component of renal cortical membranes as well as membrane fluidity and Na+, K+, ATPase activity have been studied in membranes from the renal cortex of rats with experimental liver cirrhosis, which show renal sodium and water retention, and in normal animals. " 01/01/2002 - "[Molecular bases for water/salt retention in experimental liver cirrhosis: aquaporins and renal sodium transporters]."
6.	Proteins (Proteins, Gene)FDA Link 12/01/1968 - "Biochemical and histochemical study of serum and tissue protein in experimental liver cirrhosis." 01/01/1962 - "[Changes in hepatic glycogen in animals with experimental liver cirrhosis treated with different protein extracts]." 11/01/1968 - "[Radioisotope investigation of the protein and mineral metabolism in teeth and bones during development of experimental liver cirrhosis]." 12/01/1963 - "[CHANGES IN LIVER PROTEINS AND BLOOD PROTEINS IN EXPERIMENTAL LIVER CIRRHOSIS AND FOLLOWING DECORTIN AND ANABOLIC STEROID TREATMENT]."
7.	RNA (Ribonucleic Acid)IBA 10/01/1970 - "[Effect of liver RNA on the course of experimental liver cirrhosis]." 03/01/1975 - "[Study of the stimulating effect of RNA and triamcinolone on the process of reverse development of experimental liver cirrhosis]."
8.	Peptides (Polypeptides)IBA 01/01/1986 - "Serum concentration of the aminoterminal procollagen type III peptide in the rat reflects early formation of connective tissue in experimental liver cirrhosis." 07/01/1994 - "The present study was undertaken to determine whether a non-peptide arginine vasopressin (AVP) antagonist [5-dimethylamino-1-(4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetra hydro-1H- benzazepine] (OPC-31260) improves the impaired water excretion in rats with experimental liver cirrhosis. "
9.	Methionine (L-Methionine)FDA Link 02/01/1957 - "[Study of the renewal of various fractions of blood proteins in experimental liver cirrhosis in rabbits; use of S35 labelled methionine and C14OOH]." 01/08/1996 - "Significant increases in glycine, alanine, serine, methionine, glutamate, ornithine, phenylalanine, tyrosine, histidine and proline were observed in rats with the resulting experimental liver cirrhosis. "
10.	Blood Proteins (Serum Proteins)IBA 02/01/1957 - "[Study of the renewal of various fractions of blood proteins in experimental liver cirrhosis in rabbits; use of S35 labelled methionine and C14OOH]." 12/01/1963 - "[CHANGES IN LIVER PROTEINS AND BLOOD PROTEINS IN EXPERIMENTAL LIVER CIRRHOSIS AND FOLLOWING DECORTIN AND ANABOLIC STEROID TREATMENT]."

Therapies and Procedures

1.	Hepatectomy 03/01/1959 - "[Quantitative studies on the chemical changes in the liver stroma in experimental liver cirrhosis and their reversal after hepatectomy]."
2.	Ligation 03/01/2006 - "Experimental liver cirrhosis was induced in rats by CCl4 treatment or common bile duct ligation. " 08/01/2012 - "To present a review about a comparative study of bile duct ligation versus carbon tetrachloride Injection for inducing experimental liver cirrhosis. " 11/01/2003 - "Protective effect of IGF-1 on experimental liver cirrhosis-induced common bile duct ligation." 08/01/1997 - "The experimental hepatic cirrhosis was induced either by bile duct ligation (BDL) or by pretreatment with dimethylnitrosamine (DMNA). "
3.	Oral Administration 01/01/1989 - "We conclude that oral administration of thioacetamide is a simple and reliable method of inducing experimental liver cirrhosis. " 11/01/1951 - "[Experimental hepatic cirrhosis in rats induced by prolonged oral administration of tannic acid]." 11/01/2007 - "New strategy for the antifibrotic therapy with oral administration of FR260330 (a selective inducible nitric oxide synthase inhibitor) in rat experimental liver cirrhosis."
4.	Microspheres (Microsphere) 06/01/1987 - "The extent of systemic arteriovenous shunting (arteriovenous anastomotic blood flow) was assessed in rats with experimental liver cirrhosis and control rats by injecting 15 micron microspheres into the left ventricle and measuring the percentage of injected spheres trapped in the pulmonary circulation. " 12/01/1993 - "Systemic and splanchnic hemodynamics in experimental liver cirrhosis in rats induced by thioacetamide were evaluated by the radioactive microsphere method. "
5.	Fetal Tissue Transplantation 08/01/2000 - "Effect of fetal tissue transplantation on reparative processes in experimental liver cirrhosis."