Alcoholic Liver Cirrhosis (Alcoholic Cirrhosis)

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1302 relevant articles (39 outcomes, 136 trials/studies) found for this Disease

Description: FIBROSIS of the hepatic parenchyma due to chronic excess ALCOHOL DRINKING.

Also Known As:

Alcoholic Cirrhosis; Liver Cirrhosis, Alcoholic; Hepatic Cirrhosis, Alcoholic; Alcoholic Hepatic Cirrhosis

Relationship Network

Disease Context: Research Results

Digestive System Diseases: 29

Liver Diseases: 19076

Liver Cirrhosis: 8939

Alcoholic Liver Cirrhosis: 1302

Alcoholic Liver Diseases: 1675

Alcoholic Liver Cirrhosis: 1302

Disorders of Environmental Origin

Substance-Related Disorders: 5516

Alcohol-Related Disorders: 35

Alcohol-Induced Disorders: 4

Alcoholic Liver Diseases: 1675

Alcoholic Liver Cirrhosis: 1302

Related Diseases

1.	Hemorrhage
2.	Chronic Hepatitis (Chronic Active Hepatitis)
3.	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis)
4.	Fatty Liver
5.	Insulin Resistance

Experts

1.	González-Sarmiento, Rogelio: 2 articles (09/2008 - 11/2005)
2.	Gerken, Guido: 2 articles (01/2006 - 05/2004)
3.	Peck-Radosavljevic, Markus: 2 articles (09/2005 - 11/2004)
4.	Lainé, Fabrice: 2 articles (05/2004 - 01/2002)
5.	Moirand, Romain: 2 articles (05/2004 - 01/2002)
6.	Brissot, Pierre: 2 articles (05/2004 - 01/2002)
7.	Kurup, Ravi Kumar: 2 articles (08/2003 - 04/2003)
8.	Kurup, Parameswara Achutha: 2 articles (08/2003 - 04/2003)
9.	Rodríguez Romano, D: 2 articles (02/2002 - 02/2002)
10.	Jiménez Romero, C: 2 articles (02/2002 - 02/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Alcoholic Liver Cirrhosis:

1.	Propranolol (Inderal)FDA LinkGeneric 10/19/1985 - "propranolol, has been shown to be effective in compensated patients with alcoholic cirrhosis" 01/01/1993 - "In conclusion, the results of this study suggest that an underlying O2 debt exists in patients with advanced alcoholic cirrhosis and that beta-adrenergic blockade with propranolol 'normalises' the O2 supply-consumption relationship resulting in more efficient O2 utilisation without adversely affecting HRS. The mechanism of this action may be related to the antagonism of beta 2-mediated arteriovenous shunting resulting in appropriate blood redistribution." 10/01/1988 - "Effect of propranolol on metabolic activity of the liver in patients with alcoholic cirrhosis." 10/01/1987 - "1 Six male patients with alcoholic cirrhosis and seven normal control subjects were each given 80 mg twice daily of conventional propranolol for 1 week and 160 mg once daily of a long acting preparation (LA) of propranolol for 1 week" 02/01/1987 - "The effect of the intravenous injection of 0.1 mg/kg of propranolol on arterial ammonemia was studied in 30 patients with alcoholic cirrhosis comparatively with 10 healthy volunteers" Order ALL the reference details at left...
2.	Immunoglobulin G (IgG)IBA 06/01/1984 - "In 58 patients with alcoholic cirrhosis, the immunoglobulin G specifically directed against the Gram-negative bacteria lipopolysaccharide expressed by the J5 mutant of Escherichia coli 0111:B4 was measured" 06/01/1991 - "We treated such a case of multiple myeloma of IgG-kappa type associated with alcoholic cirrhosis" 06/01/1991 - "IgG-kappa type multiple myeloma in alcoholic cirrhosis--a case report." 04/25/1983 - "In primary biliary cirrhosis the mean IgG concentration was 93% higher than in alcoholic cirrhosis" 02/01/1983 - "Membrane-bound IgG and lymphocytotoxic activity of total, T-enriched and T-depleted lymphocytes, using autologous hepatocytes have been evaluated in: (a) 31 patients with chronic active hepatitis (CAH) (six autoimmune and 25 hepatitis B virus - HBV-related); (b) five patients with inactive alcoholic cirrhosis; and (c) nine subjects with normal hepatic histology" Order ALL the reference details at left...
3.	ZincIBA 11/01/1988 - "The estimation of the zinc content in subcellular fractions of the liver performed in postmortem specimens from seven patients with alcoholic liver cirrhosis and in six controls revealed a significant reduction in the zinc content in the fraction containing cell nuclei and membranes and in the mitochondrial fraction" 09/01/2005 - "The aim of this study was to examine the influence of zinc on spontaneous and in vitro alcohol-induced apoptosis of peripheral blood mononuclear cells (PBMCs) of patients with alcoholic cirrhosis" 12/01/1986 - "The aim of our study was to show that zinc supplementation may improve cellular immunity in patients with alcoholic cirrhosis" 05/01/1983 - "4. Patients with alcoholic cirrhosis in this study were not demonstrated to be zinc-deficient." 05/01/1983 - "A study of zinc metabolism in alcoholic cirrhosis." Order ALL the reference details at left...
4.	SilymarinIBA 01/01/2001 - "However, upon subanalysis, silymarin 420 mg/day had a significantly beneficial effect on patient survival rate (compared with patients receiving placebo) in 1 randomised, double-blind trial in patients with alcoholic cirrhosis" 02/01/2004 - "The antioxidant silymarin also successfully opposed alcoholic cirrhosis in baboons and in some but not all clinical trials; this effect also pertains to a-tocopherol" 01/01/2002 - "METHODS: Sixty consecutive patients with alcoholic liver cirrhosis were randomized to receive either silymarin MZ-80 (S) (150 mg t.i.d" 01/01/2002 - "AIM: Clinical outcome,biochemical profile and the antiperoxidative effects of silymarin MZ-80 during 6 months treatment were investigated in patients with alcoholic liver cirrhosis" 01/01/2002 - "Effects of silymarin MZ-80 on oxidative stress in patients with alcoholic cirrhosis" Order ALL the reference details at left...
5.	Testosterone (Sustanon)FDA LinkGeneric 04/01/1987 - "In conclusion, oral testosterone treatment of men with alcoholic cirrhosis does not explain the significant improvement of liver haemodynamics and function observed in this study" 09/01/1986 - "A double-blind, placebo-controlled multicenter trial was conducted to determine the efficacy of oral testosterone treatment (200 mg three times daily) in men with alcoholic cirrhosis" 07/01/1987 - "The effect of oral testosterone treatment (200 mg tid) on liver morphology was examined in a double-blind, placebo controlled study including men with alcoholic cirrhosis (n = 126)" 12/01/1988 - "The present review summarizes the pathogenic mechanisms leading to variation of plasma testosterone concentrations, consequences of hypoandrogenization and hyperoestrogenization, and effects of oral testosterone treatment in men with alcoholic cirrhosis" 12/01/1988 - "Testosterone and alcoholic cirrhosis" Order ALL the reference details at left...
6.	S-Adenosylmethionine (Ademetionine)IBA 01/01/2005 - "Some complementary and alternative medicinal agents, such as milk thistle and S-adenosylmethionine, may be effective in alcoholic cirrhosis" 06/01/1999 - "The aim of this study was to investigate the effects of AdoMet treatment in human alcoholic liver cirrhosis" 06/01/1999 - "S-adenosylmethionine in alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind, multicenter clinical trial." 08/01/2003 - "Some complementary and alternative medicine agents, such as milk thistle and S-adenosylmethionine, may be effective in alcoholic cirrhosis" 07/01/1998 - "BACKGROUND: S-adenosylmethionine (SAMe) increases survival in alcoholic liver cirrhosis and may have a beneficial effect in cholestatic liver disease" Order ALL the reference details at left...
7.	Insulin (Novolin)FDA Link 04/01/1997 - "METHODS: A 12-month open, controlled study was conducted in two well-matched groups of insulin-treated diabetics with alcoholic cirrhosis" 02/01/1992 - "The alterations in insulin processing characteristics were more frequent in patients with alcoholic cirrhosis and more severe liver impairment and correlated with the changes in the lipid composition of erythrocyte membranes" 11/01/1983 - "Insulin sensitivity in alcoholic cirrhosis." 11/01/1984 - "We conclude that, in patients with alcoholic cirrhosis, insulin resistance is caused both by a marked decrease in sensitivity to insulin and a decreased maximum effect of insulin, indicating a combined receptor-postreceptor defect as the underlying cause." 08/01/2001 - "In alcoholic cirrhosis, insulin resistance occurs with respect to carbohydrate metabolism, although the actions of insulin to suppress protein degradation and stimulate amino acid uptake are unimpaired" Order ALL the reference details at left...
8.	Antipyrine (Phenazone)FDA LinkGeneric 01/01/1993 - "Compared to controls, patients with alcoholic and non-alcoholic cirrhosis showed a comparable significant reduction in antipyrine clearance and increase in antipyrine half-life" 01/01/1993 - "This study compared the metabolism of antipyrine to its metabolites in 30 patients with alcoholic cirrhosis to 15 patients with non-alcoholic cirrhosis and 20 healthy controls" 01/01/1993 - "No significant differences in the parameters of antipyrine elimination, however, were observed between patients with alcoholic and non-alcoholic cirrhosis" 01/01/1993 - "Antipyrine elimination in patients with alcoholic and non-alcoholic cirrhosis." 11/01/1984 - "Alcoholic liver cirrhosis had no effect on the apparent volume of distribution of antipyrine, but antipyrine plasma clearance was substantially reduced in the patients" Order ALL the reference details at left...
9.	Serum AlbuminIBA 01/01/1976 - "Gastric clearance of serum albumin in patients with alcoholic liver cirrhosis." 04/01/2005 - "Low serum albumin, low ascitic fluid protein and alcoholic cirrhosis were related to development of SBP (P < 0.05)" 12/01/1989 - "In 20 cases of non-alcoholic liver cirrhosis having BCAA/AAA less than 1.8, oral supplementation with branched-chain amino acid granules (BCAA-G) for 6 months or more (median 27 months, range 7-62 months) brought about significant increase of plasma BCAA concentration, BCAA/AAA molar ratio, and serum albumin concentration" 04/01/2005 - "Additionally, low serum albumin (2.8 g/dL), gastrointestinal bleeding, alcoholic cirrhosis and low ascitic fluid protein were significantly associated with multiple occurrences of SBP" 01/01/1994 - "Serum albumin and cholineesterase levels were decreased more remarkably in patients with alcoholic liver cirrhosis than in patients with viral liver cirrhosis" Order ALL the reference details at left...
10.	Fc Receptors (Fc Receptor)IBA 08/01/1995 - "Expression, saturation, and endocytosis of IgA Fc receptors (Fc alpha R) were analyzed in blood phagocytic cells of patients with alcoholic liver cirrhosis (ALC)" 08/01/1995 - "Altered expression of monocyte IgA Fc receptors is associated with defective endocytosis in patients with alcoholic cirrhosis" 04/01/1985 - "Twenty-one patients with primary IgA nephropathy, 7 patients with Henoch-Schönlein nephritis and 4 patients with IgA nephropathy associated to alcoholic liver cirrhosis were tested for Fc-receptor phagocyte function by measuring the clearance of radiolabelled IgG-sensitized erythrocytes in vivo and the immune phagocytosis by monocytes in vitro" 10/01/1991 - "Fc receptor-mediated clearance of immunoglobulin G-coated autologous erythrocytes was studied in patients with primary biliary cirrhosis (n = 14), alcoholic liver cirrhosis (n = 5) and healthy reference individuals (n = 14)" 01/01/1985 - "The number of C3b receptors detected on 100 monocytes was significantly lower in patients with primary biliary cirrhosis (23.0 +/- 12.0, mean +/- 1 SD) compared with normal controls (57.4 +/- 16.9) and other chronic liver disease (HBsAg negative chronic active hepatitis 62.0 +/- 17.0, alcoholic cirrhosis 50.9 +/- 4.0), while the number of Fc receptors detected on 100 monocytes was not significantly different in all the groups (primary biliary cirrhosis 72.8 +/- 28.6, chronic active hepatitis 74.7 +/- 14.0, alcoholic cirrhosis 58.0 +/- 13.5 and normal controls 69.6 +/- 19.9)" Order ALL the reference details at left...

Therapies and Procedures

1.	Liver Transplantation 04/25/1992 - "The experience of a number of pioneering centers has shown that liver transplantation affords good results in alcoholic cirrhosis in terms of patient survival and social reinsertion" 06/01/1999 - "The aim was to assess the efficacy of liver transplantation in patients with alcoholic cirrhosis" 06/01/1999 - "Evaluation of efficacy of liver transplantation in alcoholic cirrhosis using matched and simulated controls: 5-year survival" 09/15/1994 - "Efficacy of liver transplantation for alcoholic cirrhosis with respect to recidivism and compliance." 08/20/1994 - "To assess the efficacy of liver transplantation in patients with alcoholic cirrhosis, we compared 2-year survival of 169 liver transplantation patients in 12 French centres with survival of two control groups treated conservatively" Order ALL the reference details at left...
2.	Transplants (Transplant) 09/01/2008 - "Methods: Eighty-seven consecutive patients with alcoholic cirrhosis from a transplant center were included" 01/01/2005 - "Furthermore, pre-transplant evaluation and selection of potential candidates are discussed and guidelines are given to clarify the role of OLT in the management of patients suffering from alcoholic cirrhosis" 01/01/2005 - "Nevertheless, there remains a certain ambivalence about the role of OLT in patients suffering from alcoholic cirrhosis, based partly on concerns regarding alcohol relapse and functional outcome post-transplant in an era of donor organ shortage and priority setting" 11/01/2004 - "However, CDT does not appear to be useful as a pretransplant screening marker for selection of potential transplant candidates suffering from alcoholic cirrhosis." 08/01/2004 - "MTHFR genotypes were determined in 300 liver transplant patients, 72 of whom had alcoholic cirrhosis with HCC and 122 of whom had alcoholic cirrhosis without HCC" Order ALL the reference details at left...
3.	Surgical Portacaval Shunt (Portacaval Anastomosis) 03/27/1976 - "A controlled study of therapeutic end-to-side portacaval shunt was carried out from 1968 to 1971 in 89 patients with alcoholic cirrhosis" 03/27/1976 - "A controlled study of therapeutic portacaval shunt in alcoholic cirrhosis." 04/01/1994 - "Partial versus total portacaval shunt in alcoholic cirrhosis" 01/01/1984 - "Evaluation of the blood flow of superior portacaval anastomoses by the measurement of azygos blood flow in patients with alcoholic cirrhosis]" 07/01/1975 - "Portacaval shunt as emergency procedure in unselected patients with alcoholic cirrhosis." Order ALL the reference details at left...
4.	Peritoneovenous Shunt 01/01/1982 - "Rapidly recurring right pleural effusion was a disabling clinical problem in a 51-year-old woman with alcoholic cirrhosis that had not been relieved by diuretic therapy or a LeVeen shunt" 01/01/1986 - "A multi-centre random trial of 57 cases of alcoholic cirrhosis with refractory ascites was carried out; 29 patients received a LeVeen shunt and 28 were treated by conventional medical therapy" 06/01/1990 - "One patient with alcoholic cirrhosis and a massive hydrothorax resistant to medical management and thoracocentesis was treated with a Denver peritoneovenous shunt" 01/01/1986 - "These observations confirm the poor prognosis for refractory ascites in cases of alcoholic cirrhosis and the inadvisability of attempting to treat it by implanting a LeVeen shunt." 09/01/1983 - "We describe two patients with alcoholic cirrhosis in whom staphylococcal right-sided endocarditis developed after insertion of a peritoneovenous shunt (PVS)" Order ALL the reference details at left...
5.	Surgical Splenorenal Shunt (Splenorenal Shunt) 01/01/1994 - "After standard distal splenorenal shunt, 50-75% of patients with alcoholic cirrhosis lose portal flow in 6-12 months: this is associated with an increased hyperdynamic systemic circulation" 01/01/1983 - "Twenty-three patients with portal hypertension due to alcoholic cirrhosis were treated by distal splenorenal shunt and gastrosplenic mesenteric disconnection" 02/15/1990 - "A survival advantage (P = 0.01) was seen in patients with alcoholic cirrhosis who had this combined therapy; however, in patients with nonalcoholic cirrhosis, survival for those receiving sclerotherapy and surgical rescue was not significantly (P = 0.36) different from that of patients receiving distal splenorenal shunt" 07/01/1977 - "These data support the conclusions that the distal splenorenal shunt is attended by the highest post-shunt survival as yet reported for patients with non-alcoholic cirrhosis, portal hypertension and bleeding varices; the procedure is safe, and in this series, the mortality has been nil for 66 consecutive operations" 01/01/1994 - "This study tested the hypothesis that reduction in the hyperdynamic systemic circulation with propranolol in patients with alcoholic cirrhosis and distal splenorenal shunt would lead to improved maintenance of portal perfusion" Order ALL the reference details at left...

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