Lithocholic Acid

A bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as cholagogue and choleretic.
Also Known As:
Isolithocholic Acid; Acid, Isolithocholic; Acid, Lithocholic; Lithocholate; Cholan-24-oic acid, 3-hydroxy-, (3alpha,5beta)-
Networked: 186 relevant articles (1 outcomes, 19 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Fickert, Peter: 4 articles (07/2014 - 02/2006)
2. Trauner, Michael: 4 articles (07/2014 - 02/2006)
3. Kato, Norihisa: 4 articles (06/2013 - 09/2009)
4. Tomotake, Hiroyuki: 4 articles (06/2013 - 09/2009)
5. Okazaki, Yukako: 4 articles (06/2013 - 09/2009)
6. Beilke, Lisa D: 3 articles (07/2009 - 03/2008)
7. Cherrington, Nathan J: 3 articles (07/2009 - 03/2008)
8. Besselsen, David G: 3 articles (07/2009 - 03/2008)
9. Chen, Pan: 2 articles (10/2015 - 05/2014)
10. Bi, Huichang: 2 articles (10/2015 - 05/2014)

Related Diseases

1. Neoplasms (Cancer)
2. Cholestasis
3. Intrahepatic Cholestasis
4. Gallstones (Gallstone)
5. Body Weight (Weight, Body)
08/01/1992 - "The present study correlated the reversibility of bile flow (BF) impairment with biochemical and morphological changes in the liver after injection of a cholestatic dose (12 mumole/100 g body weight) of lithocholic acid (LCA). "
05/01/1984 - "This study demonstrates that the newborn guinea pig is less susceptible to cholestasis induced by 90 to 180 mumoles per kg body weight of lithocholate and that, in the neonatal liver, there is no defect in the transport of this bile acid from blood to bile."
01/04/1991 - "We studied the effects of the infusion of lithocholate and lithocholate-3-sulfate and 3-glucuronide in rats (0.29 mumol/min per 100 g body weight for 40 min) on bile flow, together with their biliary excretion and metabolism. "
03/01/1993 - "Female conventional ICR mice received 0.5 mg of N-methyl-N-nitrosourea (MNU) three times in one week intrarectally or 16 mg/kg body weight of 1,2-dimethylhydrazine (DMH) subcutaneously once a week for 10 weeks, followed by a basal diet (CE-2), or CE-2 containing SLC or lithocholic acid (LC) (both at 0.5 mmol/100 g CE-2) for 40 weeks. "
04/01/1980 - "The results were summarized as follows: (a) oral administration of taurine for 10 days increased taurine-conjugated bile acids and the ratio of glycine- to taurine-conjugated bile acids (G:T ratio) shifted from 3.95 to 0.19; (b) in taurine fed guinea pigs, the half-life of chenodeoxycholic acid (CDC) was about 40% shorter than that in controls and the fractional turnover rate increased by 70%; (c) the synthetic rate (mg/day/500 g body weight) of bile acids increased from 4.28 to 7.27 by taurine feeding; (d) hepatic cholesterol 7 alpha-hydroxylase activity was increased 2.4-fold by taurine feeding; (e) the total pool size of bile acids did not change significantly but the amount of lithocholic acid in the caecum and large intestine increased by about 40%; (f) neither free cholesterol nor cholesterol ester levels in liver and serum changed significantly. "

Related Drugs and Biologics

1. Bile Acids and Salts (Bile Acids)
2. Chenodeoxycholic Acid (Chenix)
3. Deoxycholic Acid (Sodium Deoxycholate)
4. Cholates
5. Ursodeoxycholic Acid (Urso)
6. Taurine
7. glycolithocholic acid
8. Taurolithocholic Acid
9. Cholestyramine Resin (Questran)
10. Adenosine Triphosphatases (ATPase)

Related Therapies and Procedures

1. Total Parenteral Nutrition
2. Cholecystectomy
3. Parenteral Nutrition
4. Oral Administration
5. Protein-Restricted Diet (Diet, Protein Restricted)