|1.||Fickert, Peter: 4 articles (07/2014 - 02/2006)|
|2.||Trauner, Michael: 4 articles (07/2014 - 02/2006)|
|3.||Kato, Norihisa: 4 articles (06/2013 - 09/2009)|
|4.||Tomotake, Hiroyuki: 4 articles (06/2013 - 09/2009)|
|5.||Okazaki, Yukako: 4 articles (06/2013 - 09/2009)|
|6.||Beilke, Lisa D: 3 articles (07/2009 - 03/2008)|
|7.||Cherrington, Nathan J: 3 articles (07/2009 - 03/2008)|
|8.||Besselsen, David G: 3 articles (07/2009 - 03/2008)|
|9.||Chen, Pan: 2 articles (10/2015 - 05/2014)|
|10.||Bi, Huichang: 2 articles (10/2015 - 05/2014)|
04/11/2013 - "We recently identified lithocholic acid (LCA) as a small molecule able to block EphA2-dependent signals in cancer cells, suggesting that its (5β)-cholan-24-oic acid scaffold can be used as a template to design a new generation of improved EphA2 antagonists. "
05/01/2010 - "In this study, a novel ST inhibitor AL10 derived from the lead compound lithocholic acid identified in our previous study is synthesized and the anti-cancer effect of this compound is studied. "
01/01/2014 - "The molecular and cellular mechanisms underlying the robust anti-aging and anti-tumor effects of lithocholic acid have emerged. "
01/01/2008 - "Cholic, deoxycholic and lithocholic acid promote tumor formation in the large intestine by a direct proliferative effect on rather undifferentiated mucosal epithelial cells. "
12/31/2006 - "Total bile acid concentration was lower in the cancer group than the biliary stone and control groups; the proportions of deoxycholic (2.2% vs. 10.2% and 23.6%, p < 0.001 and p < 0.001, respectively) and lithocholic acid (0.3% vs. 0.6% and 1.0%, p = 0.065 and p < 0.001, respectively) were also lower. "
05/01/2014 - "In this study, we characterized the protective effect of OA at low doses against lithocholic acid (LCA)-induced cholestasis in mice and explored further mechanisms. "
09/15/1994 - "In the present study, lithocholic acid (LCA) metabolism was assessed by radiochromatography and gas-liquid chromatography-mass spectrometry, and its relationship to cholestasis was investigated. "
10/01/2015 - "Retention of the hydrophobic lithocholic acid supports its toxic role in drug-induced cholestasis. "
04/01/2011 - "Lithocholic acid (LCA) is an endogenous compound associated with hepatic toxicity during cholestasis. "
04/01/2011 - "Lithocholic acid disrupts phospholipid and sphingolipid homeostasis leading to cholestasis in mice."
12/01/2012 - "This study demonstrated that TGFβ regulates hepatic phospholipid and bile acid homeostasis through MAD homolog 3 (SMAD3) activation as revealed by lithocholic acid-induced experimental intrahepatic cholestasis. "
08/01/2014 - "In addition, a positive correlation between CoQ and ursodeoxycholic/lithocholic acid ratio was found in intrahepatic cholestasis suggesting that increased plasma lithocholic acid may be intimately related to CoQ depletion in blood and tissues. "
07/03/2014 - "Lithocholic acid (LCA) supplementation in the diet results in intrahepatic cholestasis and bile infarcts. "
07/10/2009 - "CAR(+/+) (WT) and CAR(-/-) (CAR-null) mice were pre-treated with compounds known to activate CAR prior to induction of intrahepatic cholestasis using the secondary bile acid lithocholic acid (LCA). "
03/01/2008 - "Lithocholic acid (LCA) was used to induce intrahepatic cholestasis. "
06/01/1989 - "The extent of the portal tract pathology could not be correlated with the presence or absence of pigment gallstones or with the levels of lithocholic acid in the hamster bile. "
06/01/1976 - "When lithocholate was injected, the majority of radioactivity in bile (50-60%) was present as sulphated conjugates, both in gallstone patients and healthy control subjects. "
06/01/1976 - "It was calculated that about one-fifth of the newly formed lithocholate was absorbed in both gallstone patients and healthy control subjects. "
06/01/1976 - "Lithocholate metabolism during chenotherapy for gallstone dissolution. "
06/04/1965 - "GALLSTONES PRODUCED EXPERIMENTALLY BY LITHOCHOLIC ACID IN RATS."
|5.||Body Weight (Weight, Body)
08/01/1992 - "The present study correlated the reversibility of bile flow (BF) impairment with biochemical and morphological changes in the liver after injection of a cholestatic dose (12 mumole/100 g body weight) of lithocholic acid (LCA). "
05/01/1984 - "This study demonstrates that the newborn guinea pig is less susceptible to cholestasis induced by 90 to 180 mumoles per kg body weight of lithocholate and that, in the neonatal liver, there is no defect in the transport of this bile acid from blood to bile."
01/04/1991 - "We studied the effects of the infusion of lithocholate and lithocholate-3-sulfate and 3-glucuronide in rats (0.29 mumol/min per 100 g body weight for 40 min) on bile flow, together with their biliary excretion and metabolism. "
03/01/1993 - "Female conventional ICR mice received 0.5 mg of N-methyl-N-nitrosourea (MNU) three times in one week intrarectally or 16 mg/kg body weight of 1,2-dimethylhydrazine (DMH) subcutaneously once a week for 10 weeks, followed by a basal diet (CE-2), or CE-2 containing SLC or lithocholic acid (LC) (both at 0.5 mmol/100 g CE-2) for 40 weeks. "
04/01/1980 - "The results were summarized as follows: (a) oral administration of taurine for 10 days increased taurine-conjugated bile acids and the ratio of glycine- to taurine-conjugated bile acids (G:T ratio) shifted from 3.95 to 0.19; (b) in taurine fed guinea pigs, the half-life of chenodeoxycholic acid (CDC) was about 40% shorter than that in controls and the fractional turnover rate increased by 70%; (c) the synthetic rate (mg/day/500 g body weight) of bile acids increased from 4.28 to 7.27 by taurine feeding; (d) hepatic cholesterol 7 alpha-hydroxylase activity was increased 2.4-fold by taurine feeding; (e) the total pool size of bile acids did not change significantly but the amount of lithocholic acid in the caecum and large intestine increased by about 40%; (f) neither free cholesterol nor cholesterol ester levels in liver and serum changed significantly. "
|1.||Bile Acids and Salts (Bile Acids)
|2.||Chenodeoxycholic Acid (Chenix)
|3.||Deoxycholic Acid (Sodium Deoxycholate)
|5.||Ursodeoxycholic Acid (Urso)
|9.||Cholestyramine Resin (Questran)
|10.||Adenosine Triphosphatases (ATPase)
|1.||Total Parenteral Nutrition
|5.||Protein-Restricted Diet (Diet, Protein Restricted)