Listeriosis (Listeria Infection)

11/01/2017 - "Listeriosis requires rapid treatment with antibiotics and most drugs suitable for Gram-positive bacteria are effective against L. "
01/15/2009 - "monocytogenes is slowly becoming antibiotic resistant, a continued surveillance of emerging antimicrobial resistance of this pathogen is important to ensure effective treatment of human listeriosis. "
12/01/2016 - "monocytogenes can usually be effectively treated with antibiotics, there is still around a 25% mortality rate with individuals who develop clinical listeriosis. "
08/01/2022 - "To analyze the clinical features, efficacy of antibiotic treatment, and outcome of neonatal listeriosis. "
02/01/2016 - "monocytogenes to certain antibiotics, therefore improving the efficacy of listeriosis treatment as well as food preservation measures."

01/01/2017 - "Moreover, rPI-PLC-based ELISA also showed seropositivity in those animals (7/30) that were culturally positive for other Listeria spp. In conclusion, rLLO can serve as a better antigen than rPI-PLC in ELISA for the serodiagnosis of listeriosis in animals; however, prior adsorption of test sera with SLO is required to avoid false positive results."
12/01/2002 - "Concomitant cytosolic delivery of two immunodominant listerial antigens by Salmonella enterica serovar typhimurium confers superior protection against murine listeriosis."
11/15/2016 - "Menin Plays a Critical Role in the Regulation of the Antigen-Specific CD8+ T Cell Response upon Listeria Infection."
01/01/2011 - "LLO is the major immuno-dominant antigen in listeriosis and is also required for protective immunity. "
10/06/2009 - "We show that cross-priming deficient mice are severely compromised in their ability to generate antigen-specific T cells to stimulate MHC I-restricted CTL responses following Listeria infection. "

01/01/2015 - "There is a major unmet need for an effective and safe vaccine against listeriosis, with the challenge that an effective vaccine needs to generate protective T cell immunity, a hitherto difficult to achieve objective. "
01/01/1980 - "A lyophilised live vaccine, developed on the basis of Listeria strain AUF (Serotype I), proved to provide adequate protection against all serotypes of listeriosis. "
11/01/2022 - "To date, no vaccine is available to treat listeriosis. "
01/01/2020 - "It is a promising vaccine for prevention of listeriosis."
12/21/2019 - "Although highly attenuated, three cases of systemic listeriosis have been reported in people following treatment with Listeria-based therapeutic vaccines. "

01/01/2017 - "However, ampicillin is a good choice for treatment of listeriosis in the study area."
01/01/2018 - "Listeria infection should be suspected in susceptible patients once there is no response to empiric antibacterial or if the initial culture report shows gram positive bacilli, the antibacterial of choice is ampicillin."
12/01/2015 - "This case reminds us that a febrile clinical presentation with brainstem involvement must generate the suspicion of a Listeria infection, and therefore ampicillin must be a part of the empirical treatment."
06/01/2015 - "Tc-99m-Annexin V-128 uptake as observed by SPECT allowed for the detection of systemic listeriosis and ampicillin treatment in mice. "
10/01/2013 - "All the isolates were susceptible to ampicillin, the preferred agent to treat listeriosis. "

07/01/2001 - "Protection against murine listeriosis by oral vaccination with recombinant Salmonella expressing hybrid Yersinia type III proteins."
01/01/2021 - "Studies suggest that gamma delta T-cells are activated by the protein components of Listeria and thus have been found to be an important mediator of resistance to Listeria infection. "
05/01/2020 - "Moreover, Riclin caused significant metabolic changes including pathways involved in glycolysis, protein synthesis and oxidative stress during Listeria infection. "
12/17/2019 - "Collectively, our results suggest that posttranslational modification of InlC exacerbates the host response upon Listeria infection.IMPORTANCE The pathogenic potential of Listeria monocytogenes relies on the production of an arsenal of virulence determinants that have been extensively characterized, including surface and secreted proteins of the internalin family. "
01/01/2018 - "Identifying when and where these virulence proteins are located in live cells over the course of Listeria infection can provide valuable information on the roles these proteins play in defining the host-pathogen interface. "

01/01/2011 - "In this study, we demonstrate that human CD8+ T cells also vary widely in their ability to secrete IFNγ within 15h of either Listeria infection or cytokine stimulation. "
08/01/1995 - "These studies suggest a novel function for hepatocytes in listeriosis: first, IFN-gamma-stimulated hepatocytes could contribute to listerial growth restriction in the liver, and second, through secretion of proinflammatory cytokines, they could promote phagocyte influx to the site of listerial growth."
06/01/2017 - "However, during Listeria infection, OVA-specific CD8+ T cells only transiently expressed inhibitory receptors in the white pulp and maintained their ability to produce cytokines and become memory cells. "
06/01/2015 - "Association between levels of CSF cytokines and outcome of listeriosis was assessed by logistic regression. "
06/01/2011 - "Cytokine profile of a premature infant with early onset listeriosis."

04/01/2009 - "First-line treatment is based on high-dose amoxicillin (> or =6g/day) and must be used for at least 3 weeks for treatment of listeriosis during pregnancy. "
09/01/2017 - "Although amoxicillin appears to have a better activity than ampicillin on the basis of in vitro studies, ampicillin is currently the drug of choice for the treatment of listeriosis. "
09/01/2008 - "The efficacies of moxifloxacin and amoxicillin were compared in vivo by survival curve assays and by studying the kinetics of bacterial growth in blood and organs in a murine model of central nervous system (CNS) listeriosis. "
01/01/2010 - "The present study deals with the evaluation of the efficacy of amoxicillin bearing poly-lactic-glycolic acid (PLGA) microsphere formulation in treatment of experimental listeriosis in Swiss albino mice. "
06/01/2014 - "Amoxicillin is the reference antibiotic for listeriosis treatment and should be administered to every pregnant patient with unexplained fever, particularly in case of consumption of at risk food. "

03/17/2015 - "Confirming previous results, DC loaded in vitro with GNP-LLO provided better protection against listeriosis than DC loaded in vitro using free LLO peptide. "
06/12/2013 - "Cells binding Listeria and secreting antilisterial peptides may have applications in protection against listeriosis as they kill Listeria better than free antilisterial peptides."
01/01/2021 - "Here, predicted peptide through the Insilico approach may become a potential remedy against listeriosis, after the wet-lab approach and clinical trials."
01/01/2012 - "In the present paper, our goal is to study the effectiveness of this peptide and the producer strain in a murine model of pregnancy-associated listeriosis. "
09/01/2015 - "Dendritic cells loaded with antigenic peptides, because of their safety and robust immune stimulation, would be ideal for induction of immunity to protect against listeriosis. "

11/01/1992 - "Results of the study show that the antibacterial efficacy of ampicillin is far superior to that of ciprofloxacin in our animal model of listeriosis."
11/01/1992 - "The efficacies of ciprofloxacin and ampicillin against Listeria monocytogenes in an immunosuppressed mouse model of listeriosis were compared. "
12/01/2019 - "Our findings suggested that trimethoprim/sulfamethoxazole, vancomycin and ciprofloxacin can be used as alternatives in the treatment of human listeriosis in Iran due to their low resistance rates."
08/01/2011 - "Colombian food isolates displayed high resistance to clindamycin, meropenem, rifampin, and ciprofloxacin (30%-65%), and the primary drugs of choice against listeriosis remain effective for most of isolates (84%)."

07/01/2000 - "In contrast, TMP/SMX has bactericidal extracellular and intracellular activity against Listeria and excellent central nervous system penetration, and thus may be effective for the treatment of refractory listeriosis."
05/01/1986 - "On the basis of the experience described in this case report as well as a review of the literature, trimethoprim-sulfamethoxazole appears to be an effective treatment of listeria infections."
08/01/2001 - "Cotrimoxazole was uniformly successful treatment of human listeriosis in this series."
12/01/2000 - "Listeriosis is an infrequent disease in patients with HIV that causes difficult diagnostic problems, principally in patients without prophylaxis with cotrimoxazole for PCP."
12/01/1999 - "The possible relationship between susceptibility to Listeria infection and the discontinuation of trimethoprim-sulfamethoxazole prophylaxis is of interest."

05/01/2010 - "Further studies are needed to elucidate the contribution of anti-TNF-a therapy to development of listeriosis. "
08/01/2008 - "Further, quantitative structure-activity relationship studies might contribute in manipulating it as a lead compound for the synthesis of new, more effective nonantibiotics, perhaps, devoid of side-effects that could be recommended as a compassionate therapy for listeriosis. "
12/10/1959 - "[Experimental studies on the induction and therapy of subacute Listeria infection in white mice. "
01/01/2023 - "However, first line therapy of invasive cerebral listeriosis is not well established. "
01/01/2022 - "Targeted therapy is an important predisposing factor for listeriosis. "

10/01/1995 - "Mice recovered from a sublethal primary Listeria infection, which acquired cell-mediated immunity, received a subcutaneous injection of anti-IFN-gamma-forming cells, or anti-TNF-forming cells, and 4 days later received an intravenous injection with 10 50% lethal dose (LD50) L. "
08/01/1985 - "Pretreatment of mice by intravenous injection with killed Listeria provided neither delayed-type hypersensitivity to Listeria protoplasm nor protection against Listeria infection. "
01/01/2015 - "1. Systemic listeriosis was induced in 14-d-old Chukar partridge chicks, Alectoris chukar, by intravenous injection of a suspension containing 10(6) cfu/ml of viable Listeria monocytogenes organisms to study the course of infection. "
11/01/1989 - "Intravenous injection of rat anti-mouse gamma interferon (IFN-gamma) monoclonal antibody as well as rabbit anti-mouse tumor necrosis factor (TNF) antibody into mice which had received a sublethal infection with Listeria monocytogenes cells resulted in acceleration of listeriosis. "

01/01/2010 - "The present study deals with the evaluation of the efficacy of amoxicillin bearing poly-lactic-glycolic acid (PLGA) microsphere formulation in treatment of experimental listeriosis in Swiss albino mice. "

08/01/2019 - "Here, the authors present two cases of severe Listeria infection occurring within 4 months after complicated liver transplantation in patients still recovering on the ward. "
08/01/2019 - "Listeriosis is usually described after kidney or bone marrow transplant, and has been less frequently reported after liver transplantation. "
08/01/2019 - "Early listeriosis after liver transplantation: Report of two cases."
08/28/2007 - "Fourteen cases of listeriosis after orthotopic liver transplantation have been reported in the English literature. "
10/01/1998 - "Listeria infection after liver transplantation: report of a case and review of the literature."

04/06/2022 - "Given the common use of licorice as a food sweetener in Western countries and a herb in Oriental medicine, our findings suggest that licorice extract can be potentially used as an antibiotic adjuvant to improve the efficacy of antimicrobial treatment of listeriosis."