Lipoxygenase (Lipoxygenase-1)

An enzyme of the oxidoreductase class primarily found in PLANTS. It catalyzes reactions between linoleate and other fatty acids and oxygen to form hydroperoxy-fatty acid derivatives.

Also Known As:

Lipoxygenase-1; Linoleate-Oxygen Oxidoreductase; Lipoxygenase-2; Linoleate Oxygen Oxidoreductase; Lipoxygenase 1; Lipoxygenase 2; Oxidoreductase, Linoleate-Oxygen; Lipoxidase; Linoleate:oxygen 13-oxidoreductase

Networked: 1308 relevant articles (19 outcomes, 101 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Matsuyama, Masahide: 12 articles (07/2009 - 11/2003)
2.	Yoshimura, Rikio: 12 articles (07/2009 - 11/2003)
3.	Kawahito, Yutaka: 11 articles (04/2009 - 11/2003)
4.	Nakatani, Tatsuya: 11 articles (04/2009 - 11/2003)
5.	Sano, Hajime: 11 articles (04/2009 - 11/2003)
6.	Hadjipavlou-Litina, Dimitra: 9 articles (03/2022 - 07/2006)
7.	Kuhn, Hartmut: 8 articles (10/2018 - 02/2003)
8.	Yang, Peiying: 7 articles (01/2022 - 09/2002)
9.	Hammock, Bruce D: 6 articles (01/2020 - 09/2013)
10.	Rao, Chinthalapally V: 6 articles (07/2014 - 01/2007)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2013 - "Previous studies have demonstrated that the lipoxygenase is considered as a potential therapeutic target and have important influence on human cancers. " 06/01/2005 - "In the present study, we investigated whether the lipoxygenase pathway in resident murine peritoneal macrophages is affected by contact with tumor cells of a different origin, e.g. " 02/21/2005 - "The goal of this study was to determine whether CLA altered mouse mammary tumor cell growth and whether specific metabolites of the lipoxygenase pathway were involved in CLA action. " 05/01/2004 - "Recent studies have demonstrated that lipoxygenase (LOX) inhibitor induces growth arrest of cancer cells through apoptosis. " 10/05/2021 - "Lipoxygenase (LOX) Pathway: A Promising Target to Combat Cancer."
2.	Inflammation (Inflammations) 04/01/1991 - "Other studies have indicated a role for macrophage-derived lipoxygenase products in production of experimental pulmonary granulomatous inflammation. " 09/09/2019 - "They also reduced acute inflammation and a number of them demonstrated lipoxygenase inhibitory activity. " 01/01/2019 - "Here we use genetic knock out model to delineate lipidomic, and metabolic changes to describe the role of lipoxygenase in advancing ischemic HF driven by leukocyte activation with signs of non-resolving inflammation. " 01/01/2018 - "These results indicate a potential protective role of ALOX5AP and 5-arachidonate lipoxygenase gene in diabetes pathogenesis, indicating further the importance of the relationship between diabetes and inflammation. " 06/01/2009 - "However, the role of lipoxygenase (LO) metabolites in the development of Th1 inflammation is poorly understood. "
3.	Infections 09/17/2022 - "Functional Study of Lipoxygenase-Mediated Resistance against Fusarium verticillioides and Aspergillus flavus Infection in Maize." 07/02/2022 - "This study lays a foundation for the function of lipoxygenase and its products during the infection of Purpureocillium lavendulum." 01/17/2000 - "In this study, isolation and characterisation of endogenous lipoxygenase metabolites formed in potato tubers in response to injury/infection was undertaken. " 11/01/2022 - "A commentary on: Differential modulation of the lipoxygenase cascade during typical and latent Pectobacterium atrosepticum infections." 11/01/2022 - "Differential modulation of the lipoxygenase cascade during typical and latent Pectobacterium atrosepticum infections."
4.	Ischemia 04/01/1990 - "This study tests the role of ischemia-induced lipoxygenase activity in mediating PMN activation and diapedesis. " 12/01/1994 - "These findings suggest that the site of action of MCl-186 as an anti-ischemic agent may be closely associated with the cerebral AA cascade, especially the lipoxygenase system, activated by ischemia-reperfusion." 04/01/1990 - "Ischemia-induced neutrophil activation and diapedesis is lipoxygenase dependent." 10/01/1991 - "This study was designed to determine the effect of thromboxane and lipoxygenase derivatives on the local and systemic response to ischemia and reperfusion of skeletal muscle. " 03/27/2013 - "This drug inhibits both nonenzymatic lipid peroxidation and the lipoxygenase pathway, in addition to having potent antioxidant effects against ischemia reperfusion. "
5.	Atherosclerosis 01/01/2010 - "Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study." 06/01/2006 - "Lipoxygenase pathways as mediators of early inflammatory events in atherosclerosis." 07/01/2004 - "Lipoxygenase pathways in atherogenesis." 02/04/2003 - "Here, we studied both lipoxygenase pathways in human atherosclerosis. " 04/01/2000 - "Inhibition of lipoxygenase-induced lipid peroxidation might, therefore, be an important mode to suppress the development of atherosclerosis. "

Related Drugs and Biologics

1.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
2.	phenidone
3.	Cyclooxygenase Inhibitors
4.	Proteins (Proteins, Gene)
5.	Arachidonic Acid (Vitamin F)
6.	Enzymes
7.	Eicosanoids
8.	Antioxidants
9.	Peroxidase (Myeloperoxidase)
10.	Curcumin

Related Therapies and Procedures

1.	Therapeutics
2.	Diet Therapy (Therapy, Diet)
3.	Surgical Instruments (Clip)
4.	Pancreas Transplantation
5.	Drug Therapy (Chemotherapy)