|1.||Sparrow, Janet R: 22 articles (01/2016 - 03/2002)|
|2.||Holz, Frank G: 10 articles (12/2015 - 12/2002)|
|3.||Koutalos, Yiannis: 10 articles (10/2015 - 11/2010)|
|4.||Holz, F G: 10 articles (07/2010 - 04/2000)|
|5.||Crouch, Rosalie K: 9 articles (10/2015 - 11/2010)|
|6.||Ablonczy, Zsolt: 9 articles (10/2015 - 11/2010)|
|7.||Radu, Roxana A: 8 articles (01/2015 - 04/2003)|
|8.||Kopitz, J: 7 articles (07/2010 - 07/2000)|
|9.||Gaillard, E R: 6 articles (01/2011 - 09/2001)|
|10.||Kim, So Ra: 6 articles (01/2010 - 08/2004)|
|1.||Macular Degeneration (Age-Related Maculopathy)
10/28/2015 - "Lipofuscin, as well as A2E, exhibit a range of cytotoxic properties, which are thought to contribute to the pathogenesis of degenerative diseases of the retina such as Age-related Macular Degeneration. "
10/01/2015 - "The accumulation of lipofuscin, an autofluorescent aging marker, in the retinal pigment epithelium (RPE) has been implicated in the development of age-related macular degeneration (AMD). "
05/01/2015 - "Age-related macular degeneration impacts individual RPE cells by (1) lipofuscin redistribution by (i) degranulation (granule-by-granule loss) and/or (ii) aggregation and apparent shedding into the extracellular space; (2) enlarged RPE cell area and conversion from convex to irregular and sometimes concave polygons; and (3) cytoskeleton derangement including separations and breaks around subretinal deposits, thickening, and stress fibers. "
05/01/2015 - "Lipofuscin redistribution and loss accompanied by cytoskeletal stress in retinal pigment epithelium of eyes with age-related macular degeneration."
02/01/2015 - "This can lead to the accumulation of lipofuscin, which is important in the pathogenesis of retina degeneration disease, such as dry type age-related macular degeneration (AMD). "
|2.||Vitamin E Deficiency
01/01/1967 - "[Studies on the quantitative distribution of lipofuscin and vitamin E deficiency-pigment in nerve cells of rats of various age groups]."
01/01/2014 - "Vitamin E deficiency can lead to formation of lipofuscin aggregates. "
01/14/1994 - "There was no statistically significant effect of vitamin E deficiency or supplementation on lipofuscin accumulation with age as compared with the control rats in all three brain regions of old rats. "
01/01/1987 - "There was no significant difference in the concentration of lipofuscin in the SON neurons after vitamin E deficiency but there was a significant increase in the adrenal cortical cells. "
10/01/1985 - "It has been widely speculated that this lipofuscin deposition is related to vitamin E deficiency. "
05/01/2015 - "Imaging of RPE atrophy using lipofuscin-based AF imaging has become the gold standard. "
02/01/1998 - "To the authors' knowledge, this is the first report of a case presenting with both diffuse brain atrophy and localized accumulation of neuronal lipofuscin, mimicking a mass lesion on radiological studies."
01/01/1992 - "Microscopic study of the kidney showed that lipofuscin granules increased in the cells of the thick ascending limb of Henle's loop to the distal convoluted tubule accompanying mild tubular atrophy and that some of the tubules of these segments had vacuolar degeneration or desquamation. "
06/01/2015 - "The most frequent surface changes were lipofuscin pigments, zones of retinal pigment epithelium atrophy, and retinal pigment epithelium pigment clumps in 31 (67.3%), 18 (39.1%), and 8 eyes (17.3%), respectively. "
08/01/2014 - "Autosomal recessive Stargardt disease may present as a central cone dysfunction syndrome before the development of lipofuscin flecks, atrophy of RPE, or full-field electroretinography abnormalities. "
|4.||Body Weight (Weight, Body)
04/01/2001 - "Treatment with MAK at a dose of 500 mg/kg body weight daily for two months reduced the lipid peroxidation and lipofuscin pigment accumulation significantly in brain regions and it also helped in restoring the normal oxygen consumption in the older animals. "
08/01/2008 - "The progressive accumulation of lipofuscin in neuronal cells is one of the most characteristic age related changes, an increase in body weight was also observed at 24 months. "
11/01/1998 - "Malnourished (n = 8) and controls (n = 4), respectively, showed statistical differences in relation to BMI (14.86 +/- 1.13 vs 22.02 +/- 0.9 kg/m2), heart weight/body weight ratio (0.68 +/- 0.09 vs 0.54 +/- 0.07%), cardiomyocytes width (10.91 +/- 0.77 vs 12.90 +/- 1.82 microns) and lipofuscin pigment presence (39.1 vs 54.4%). "
11/01/1978 - "The effects of NO2 exposure on body weights, tissue weights, survival rates, and tissue organic solvent soluble lipofuscin (age) pigment concentrations were examined. "
11/01/1978 - "I. Effect on body weights and lipofuscin pigments."
|5.||Alzheimer Disease (Alzheimer's Disease)
03/01/1978 - "It seems, therefore, unlikely that removal of lipofuscin, per se, has any bearing on this reported improvement in intellectual capability, nor is it implicated in the aetiology of senile dementia."
07/01/1984 - "This work is to study the ultrastructure of the neuronal lipofuscin that occurred in the brain and the spinal cord of an autopsy case of familial Alzheimer's disease and to compare with those in several other diseases. "
07/01/1984 - "[Ultrastructural study of the neuronal lipofuscin--an autopsy case of familial Alzheimer's disease]."
01/01/1978 - "Using serially sectioned spinal cords, studies were made on the number of Alzheimer's neurofibrillary tangles, and the distribution of lipofuscin in five cases of clinically and histopathologically confirmed Alzheimer's disease, 10 cases of similarly confirmed senile dementia and 10 cases of mentally normal people. "
01/01/2011 - "Lipofuscin hypothesis of Alzheimer's disease."
|5.||Complement System Proteins (Complement)
|10.||Monoamine Oxidase (MAO)
|2.||Intraocular Lenses (Intraocular Lens)
|4.||Transplantation (Transplant Recipients)