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Linoleic Acids

Eighteen-carbon essential fatty acids that contain two double bonds.
Also Known As:
Acids, Linoleic
Networked: 51 relevant articles (3 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Willett, Walter C: 2 articles (01/2008 - 09/2005)
2. Clark, Robert Sb: 1 article (02/2015)
3. Skoda, Erin M: 1 article (02/2015)
4. St Croix, Claudette M: 1 article (02/2015)
5. Kochanek, Patrick M: 1 article (02/2015)
6. Anthonymuthu, Tamil S: 1 article (02/2015)
7. Kline, Anthony E: 1 article (02/2015)
8. Baart, Sophie: 1 article (02/2015)
9. Bayır, Hülya: 1 article (02/2015)
10. Tyurina, Yulia Y: 1 article (02/2015)

Related Diseases

1. Neoplasms (Cancer)
2. Melanoma (Melanoma, Malignant)
3. Atherosclerosis
4. Juvenile Rheumatoid Arthritis (Juvenile Idiopathic Arthritis)
5. Ischemia
02/01/2015 - "Here, we report an alternative pathway whereby cereberal ischemia-reperfusion triggered oxygenation of a mitochondria-specific phospholipid, cardiolipin (CL), is followed by its hydrolysis to yield monolyso-CLs and oxygenated derivatives of fatty (linoleic) acids. "
05/01/1990 - "The levels of both saturated and unsaturated NEFA increased during ischemia for 20 min in the working heart but not in the Langendorff heart, although unsaturated NEFA increased in the Langendorff heart when the ischemic period was 40 min. Arachidonic and linoleic acids were the NEFA that accumulated most prominently."
12/06/2002 - "Thapsigargin, an inhibitor of the Ca(2+)-ATPase ER uptake pump, elicited significant elevations in the efflux of myristic, arachidonic and linoleic acids, in the absence of ischemia. "
01/01/1991 - "Addition of arachidonic or linoleic acids to control rat heart mitochondria, inhibits electron transport between Complex I and III. These results are consistent with the following hypothesis: during ischemia, the intracellular energy content drops severely, affecting the cytoplasic concentration of ions such as Na+ and Ca2+. Upon reoxygenation, the mitochondrion is the only organelle capable of eliminating the excess cytoplasmic Ca2+ through an electrogenic process requiring oxygen (the low ATP concentration makes other ATP-dependent Ca2+ transport systems non-operational).(ABSTRACT TRUNCATED AT 250 WORDS)"
01/01/1990 - "Ischemia was produced by lowering the afterload pressure from 60 to 0 mm Hg, and reperfusion resulted from raising the afterload pressure to 60 mm Hg. Ischemia stopped the heart beat, and increased the myocardial levels of unsaturated NEFA (such as arachidonic, palmitoleic, and linoleic acids) as a function of the ischemic period; it decreased the myocardial levels of ATP and CrP, and increased the myocardial level of lactate. "

Related Drugs and Biologics

1. Acids
2. Dinoprostone (PGE2)
3. Indomethacin (Indometacin)
4. Dietary Fats (Ghee)
5. Oleic Acid (Oleate)
6. Interleukin-6 (Interleukin 6)
7. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
8. Phosphatidylcholines (Phosphatidylcholine)
9. Erucic Acids
10. C-Reactive Protein

Related Therapies and Procedures

1. Heterologous Transplantation (Xenotransplantation)