Lignin

The most abundant natural aromatic organic polymer found in all vascular plants. Lignin together with cellulose and hemicellulose are the major cell wall components of the fibers of all wood and grass species. Lignin is composed of coniferyl, p-coumaryl, and sinapyl alcohols in varying ratios in different plant species. (From Merck Index, 11th ed)

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Networked: 530 relevant articles (17 outcomes, 42 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Tobimatsu, Yuki: 7 articles (06/2022 - 11/2013)
2.	Chapple, Clint: 7 articles (01/2019 - 12/2010)
3.	Bi, Yang: 6 articles (05/2022 - 06/2021)
4.	Prusky, Dov: 6 articles (05/2022 - 06/2021)
5.	Sakagami, Hiroshi: 6 articles (08/2020 - 07/2008)
6.	Kai, Dan: 4 articles (07/2022 - 01/2020)
7.	Loh, Xian Jun: 4 articles (07/2022 - 01/2020)
8.	Wang, Bin: 4 articles (05/2022 - 06/2021)
9.	Ralph, John: 4 articles (12/2019 - 10/2004)
10.	Kim, Jeong Im: 4 articles (01/2019 - 11/2013)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2017 - "In vitro evaluation of biodegradable lignin-based nanoparticles for drug delivery and enhanced antiproliferation effect in cancer cells." 01/01/1997 - "Dietary lignin did not significantly affect colon tumor incidence or multiplicity compared with the fiber-free diet. " 08/01/1995 - "Our results on the presence of specific lignin fractions in high-risk food items that can induce important cellular functions linked to tumor promotion are discussed in relation to NPC genesis and etiology." 03/01/1992 - "Differential responses of lignin derivatives between tumor and normal tissue derived cell lines; effects on cellular adhesion and cell growth." 06/01/1990 - "Morphological changes of tumor cells caused by macrophages treated with lignin derivatives."
2.	Infections 01/01/2023 - "To study the changes of lignin due to Septoria infection, four field grown, naturally variant Populus trichocarpa exhibiting visible signs of Septoria infection were sampled at health, infected, and reaction zone regions for cell wall characterization. " 03/01/2021 - "In this study, we compared the defense transcriptomes of cotton (Gossypium hirsutum) cultivars Shidalukang 1 (Verticillium dahliae resistant, HR) and Junmian 1 (V. dahliae susceptible, HS) before and after V. dahliae infection, identified hub genes of the network associated with responses to V. dahliae infection, and functionally characterized one of the hub genes involved in biosynthesis of lignin and phenolics. " 11/01/2023 - "Infection with a fungal pathogen Macrophomina phaseolina, responsible for dry root rot (DRR) disease in chickpea, induced local lignin deposition and LAC gene expression. " 05/15/2023 - "Consistent with transcriptome and metabolomic analysis, microscopic observations showed enhanced lignin accumulation in the roots of the Piri and Piri+Fp lines, most likely contributing to the arrested infection by F. " 01/01/2023 - "notoginseng can establish a lignin barrier that restricted RKN to the infection site. "
3.	Wounds and Injuries (Trauma) 03/25/2020 - "In this study, we analyzed wound-induced lignin deposition in cotyledons of the Arabidopsis thaliana ecotypes Landsberg erecta and Columbia and assessed ectopic lignin depositions in roots of lignescence (lig) mutants of Arabidopsis. " 12/01/2023 - "The method we used has some significance for the preparation of MoS2 nanosheets, and composite films prepared from MoS2, and lignin can be used in food packaging, wound antimicrobials, and other fields." 08/01/2023 - "guilliermondii could promote deposition of guaiacyl-syringyl-p-hydroxyphenyl type lignin by activating the biosynthesis and polymerization of monolignols at the wounds of potato tubers." 08/01/2023 - "Lignin is a crucial component in the wound tissue of tubers. " 08/01/2023 - "Meyerozyma guilliermondii promoted the deposition of GSH type lignin by activating the biosynthesis and polymerization of monolignols at the wounds of potato tubers."
4.	Disease Resistance 08/01/2023 - "Overall, the present study provides important references and suggests that future research should be aimed at elucidating the detailed mechanisms of the carbon flux allocation between phenylpropenes and lignin biosynthesis, as well as the disease resistance competency." 04/01/2021 - "In this study, we present an example in cotton whereby plants with reduced lignin content also exhibit enhanced disease resistance. " 02/01/2009 - "Despite a hypothesized direct relationship between preformed lignin content and disease resistance, previous studies on soybean have correlated lignin content to nutritional value and not to disease resistance. " 01/01/2023 - "Numerous genes involved in cell wall biogenesis, remodeling, and cell wall-based defense, including lignin synthesis, were also upregulated in the resistant cultivar, indicating the possible role of wall composition in disease resistance. " 01/01/2023 - "Furthermore, autophagic activity and lignin accumulation were both enhanced in dnd1 (defense, no death 1) mutant with elevated disease resistance but no cell death and crossing dnd1-1 with atg mutants resulted in a lignin deficit, further supporting that lignin formation requires autophagy. "
5.	Weight Loss (Weight Reduction) 06/08/2023 - "The loss weight and water contact angle (WCA, 75.6-63.6°) of the LPUs decreased with the increased lignin content. " 07/06/2021 - "The maximum weight loss temperature of the hydrotropic lignin was in the range of 330-350 °C, higher than the alkaline lignin, and the glass conversion temperature (Tg) of the hydrotropic lignin was in the range of 107-125 °C, lower than that of the alkaline lignin. " 06/01/2020 - "The biosynthesis of lignin in wounded tissues significantly decreased the weight loss of sweet potatoes. " 01/01/2019 - "The thermal stability was remarkable providing a Tid (2% of weight loss) of 230 °C of the copolymers, compared with 69 °C for the pristine lignin." 04/01/2018 - "Two significant weight loss peaks with the closer values were observed in DTG curve of PKS that differentiated with other samples, which was mainly attributed to the content and especially the structural characteristics of lignin in the PKS. "

Related Drugs and Biologics

1.	Cellulose
2.	Antioxidants
3.	Hydrogels
4.	Enzymes
5.	Flavonoids
6.	callose
7.	Cholesterol
8.	Bile Acids and Salts (Bile Acids)
9.	hemicellulose
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Drug Therapy (Chemotherapy)
4.	Precision Medicine
5.	Kampo Medicine (Kampo)