|1.||Xu, Guang-Yin: 11 articles (07/2015 - 01/2009)|
|2.||Glass, David J: 11 articles (05/2014 - 02/2003)|
|3.||Sun, Yi: 10 articles (06/2014 - 11/2003)|
|4.||Silverman, Robert H: 8 articles (06/2014 - 01/2003)|
|5.||van der Donk, Wilfred A: 8 articles (02/2011 - 02/2006)|
|6.||Jiang, Xinghong: 7 articles (01/2015 - 01/2012)|
|7.||Willis, Monte S: 7 articles (01/2015 - 12/2009)|
|8.||Hasselgren, Per-Olof: 7 articles (10/2013 - 05/2003)|
|9.||Häberle, Johannes: 6 articles (11/2015 - 05/2004)|
|10.||Benveniste, Olivier: 6 articles (07/2015 - 06/2011)|
04/01/1986 - "It is postulated that PG synthetase inhibitor may prove to be a good therapeutic tool effective against human cancer when used in combination with chemotherapeutic and other immunotherapeutic drugs as well as with low-dose radiation therapy."
01/01/2015 - "Ubiquitination by E3 ligases may induce cellular relocation of p53 and determine the outcome of p53-mediated stress response, including cell proliferation, apoptosis and efficacy of cancer therapy. "
04/01/2013 - "RING E3 ligases have the subject of intense studies for their roles in many diseases including cancer and as potential therapeutic targets. "
08/01/2005 - "Studies on the tumor suppressor p53 have indeed demonstrated that poly-ubiquitination of p53 by different E3 ubiquin ligases targets p53 for degradation by the 26S proteasomes. "
09/01/1992 - "Progestin-induced fatty acid synthetase in human mammary tumors: from molecular to clinical studies."
01/01/2015 - "The tomato SlHUB1 and SlHUB2 had H2B monoubiquitination E3 ligases activity in vitro and expression of SlHUB1 and SlHUB2 was induced by infection of B. "
12/01/2014 - "After IAV infection, viral levels were increased 2-fold in hBECs from asthmatic subjects compared with nonasthmatic control subjects (P < .05) and this increase occurred in concert with increased IFN-λ1 levels and no significant difference in IFNB1, 2'-5'-oligoadenylate synthetase 1, or myxovirus (influenza virus) resistance 1mRNA levels. "
09/01/2014 - "Association of dengue virus infection susceptibility with polymorphisms of 2'-5'-oligoadenylate synthetase genes: a case-control study."
04/01/2014 - "These data suggest that there are infection-phase-specific and anatomically compartmentalized differences in TRIM5α and TRIM22 regulation involving primarily IFN-I and specific cell types and indicate subtle differences in the antiviral roles and transcriptional regulation of TRIM E3 ligases in vivo. "
11/01/2013 - "The sidE gene encodes a bimodular peptide synthetase and was shown previously to be strongly upregulated during initiation of murine lung infection. "
|3.||Myositis (Idiopathic Inflammatory Myopathies)
09/01/2015 - "Combining these facets of Jo-1-mediated immunity now supports a more integrated model of disease pathogenesis that should lead to improved therapeutic targeting in the anti-synthetase syndrome and related subsets of idiopathic inflammatory myopathy."
12/01/2006 - "They have improved the diagnosis of myositis by leading to the identification of characteristic clinical patterns, such as anti-synthetase syndrome. "
12/01/2015 - "We used four different immunodot kits (D-Tek, Mons, Belgium): ANA25 Quantrix, Synthetase 10 Diver, Myositis 7 Diver and Liver 10 profile Diver, all automatized on the BlueDiver Instrument (D-Tek). "
11/21/2015 - "A case of anti-PL7 antibody positive myositis and a clinical and pathological review of the anti-synthetase syndrome."
04/01/2014 - "Idiopathic inflammatory myopathies and the anti-synthetase syndrome: a comprehensive review."
08/01/2004 - "Poly(adenosine 5'-diphosphate-ribose) synthetase (PARS) inhibitor has been suggested to attenuate the ischemia-reperfusion injury in myocardial infarction by preventing energy depletion associated with oxidative stress. "
06/01/2004 - "Intratracheal poly (ADP) ribose synthetase inhibition ameliorates lung ischemia reperfusion injury."
01/01/1984 - "These data suggest an efficacy of PGI2 administration but not of TX synthetase inhibition in preserving the myocardium from reperfusion injury. "
02/01/2001 - "The present study was undertaken to determine the possible deleterious role played by poly(adenosine diphosphate-ribose) synthetase (PARS) in cochlear ischemia-reperfusion injury. "
02/15/2014 - "Inhibition of long chain fatty acyl-CoA synthetase (ACSL) and ischemia reperfusion injury."
|5.||Muscular Atrophy (Muscle Atrophy)
01/01/2008 - "Here, we show that intraperitoneal injection of endotoxin (lipopolysaccharide, LPS) in mice resulted in higher level of ROS and greater expression of muscle-specific E3 ubiqitin ligases, muscle atrophy F-box (MAFbx)/atrogin-1 and muscle RING finger-1 (MuRF1), in glycolytic white vastus lateralis muscle than in oxidative soleus muscle. "
11/04/2011 - "Blocking the expression of these two ubiquitin ligases provides protection against muscle atrophy. "
01/01/2007 - "The present study determined whether thermal injury increases the expression of the ubiquitin (Ub) E3 ligases referred to as muscle ring finger (MuRF)-1 and muscle atrophy F-box (MAFbx; aka atrogin-1), which are muscle specific and responsible for the increased protein breakdown observed in other catabolic conditions. "
05/01/2015 - "Muscle atrophy F-Box (MAFbx)/atrogin-1 and muscle ring-finger-1 (MuRF-1) have been identified as two muscle-specific E3 ubiquitin ligases that are highly expressed in skeletal muscle during muscle atrophy. "
01/01/2015 - "Finally, we identify FoxO-dependent ubiquitin ligases including MUSA1 and a previously uncharacterised ligase termed SMART (Specific of Muscle Atrophy and Regulated by Transcription). "
|2.||Poly Adenosine Diphosphate Ribose
|4.||Acyl Coenzyme A (Acyl CoA)
|5.||Nitric Oxide (Nitrogen Monoxide)
|6.||Carbamyl Phosphate (Carbamoyl Phosphate)
|7.||Glutathione (Reduced Glutathione)
|10.||DNA (Deoxyribonucleic Acid)
|2.||Drug Therapy (Chemotherapy)
|5.||Transplantation (Transplant Recipients)