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Luteinizing Hormone (Lutropin)

A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity.
Also Known As:
Lutropin; LH (Luteinizing Hormone); Interstitial Cell-Stimulating Hormone; Luteoziman; Luteozyman; Hormone, Interstitial Cell-Stimulating; Hormone, Luteinizing; Interstitial Cell Stimulating Hormone; ICSH (Interstitial Cell Stimulating Hormone); Luteinizing hormone
Networked: 2148 relevant articles (30 outcomes, 154 trials/studies)

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Drug Context: Research Results

Experts

1. Smith, Mark A: 11 articles (07/2014 - 11/2002)
2. Atwood, Craig S: 9 articles (04/2008 - 11/2002)
3. Perry, George: 9 articles (12/2007 - 11/2002)
4. Casadesus, Gemma: 8 articles (07/2014 - 04/2005)
5. Bowen, Richard L: 8 articles (12/2007 - 11/2002)
6. Martins, Ralph N: 7 articles (11/2015 - 11/2002)
7. Huhtaniemi, Ilpo: 7 articles (03/2014 - 05/2005)
8. Veldhuis, Johannes D: 7 articles (09/2011 - 04/2002)
9. Webber, Kate M: 7 articles (12/2007 - 04/2005)
10. Verdile, Giuseppe: 6 articles (11/2015 - 05/2004)

Related Diseases

1. Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal)
2. Prostatic Neoplasms (Prostate Cancer)
3. Body Weight (Weight, Body)
09/01/2013 - "After 48 days of treatment, sperm concentrations were (87.85 +/- 28.44), (7.11 +/- 2.15), (35.98 +/- 14.04), (32.65 +/- 11.80) and (33.51 +/- 13.26) x 10(6)/ml in the blank control, infertile model, high-dose YJF, mid-dose YJF, and low-dose YJF groups, respectively; sperm motilities were (52.79 +/- 16.43), (31.14 +/- 3.07), (45.88 +/- 16.97), (51.56 +/- 13.35) and (49.53 +/- 10.16)%; the T levels were (194.07 +/- 40.29), (61.27 +/- 13.70), (121.87 +/- 24.35), (127.44 +/- 19.38) and (127.81 +/- 20.28) nmol/L; the luteinizing hormone (LH) levels were (7.017 +/- 0.269), (6.117 +/- 0.894), (7.060 +/- 0.871), (7.156 +/- 0.937) and (6.967 +/- 0.778) IU/L; the testis volumes were (3.775 +/- 0.183), (2.865 +/- 0.258), (3.236 +/- 0.058), (3.457 +/- 0.066) and (3.398 +/- 0.091) g; the epididymis volumes were (1.119 +/- 0.116), (0.833 +/- 0.226), (1.124 +/- 0.104), (1.132 +/- 0.107) and (1.114 +/- 0.106) g; the prostate volumes were (176.75 +/- 427.09), (131.67 +/- 39.45), (178.70 +/- 37.97), (180.11 +/- 37.39) and (179.00 +/- 35.42) mg; and the body weights were (188.50 +/- 7.12), (189.92 +/- 6.67), (187.42 +/- 5.47), (189.17 +/- 6.19) and (188.75 +/- 6.12) g. "
09/01/2013 - "Alarin was shown to stimulate food intake, increase body weight, induce luteinizing hormone secretion and stimulate fos-expression in rats; the anatomical localization for these functions correlates well with the varied distribution of the alarin peptide in the brain. "
04/01/2012 - "Effects of alarin on food intake, body weight and luteinizing hormone secretion in male mice."
08/01/2008 - "Using an enzyme-linked immunosorbent assay (ELISA), we found a significant decrease in levels of plasma luteinizing hormone (LH) at a dose of 3.0 mg/kg body weight. "
08/01/2005 - "In male rodents and primates, intracerebroventricular (icv) infusions of GALP stimulate luteinizing hormone (LH) release, induce Fos expression in brain areas implicated in feeding and reproduction, and affect food intake and body weight in rodents. "
4. Infertility (Sterility)
5. Spontaneous Abortion (Miscarriage)

Related Drugs and Biologics

1. Follicle Stimulating Hormone (Follitropin)
2. Testosterone (Sustanon)
3. Prolactin
4. Gonadotropin-Releasing Hormone (GnRH)
5. Estradiol (Estrace)
6. Progesterone
7. Insulin (Novolin)
8. Hormones
9. LH Receptors (LH Receptor)
10. Gonadotropins

Related Therapies and Procedures

1. Aftercare (After-Treatment)
2. Hormone Replacement Therapy (Therapy, Hormone Replacement)
3. Orchiectomy (Orchidectomy)
4. Injections
5. Drug Therapy (Chemotherapy)