Levallorphan (Lorfan)

An opioid antagonist with properties similar to those of NALOXONE; in addition it also possesses some agonist properties. It should be used cautiously; levallorphan reverses severe opioid-induced respiratory depression but may exacerbate respiratory depression such as that induced by alcohol or other non-opioid central depressants. (From Martindale, The Extra Pharmacopoeia, 30th ed, p683)

Also Known As:

Networked: 30 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Kinugasa, Masato: 1 article (02/2019)
2.	Miyake, Mayu: 1 article (02/2019)
3.	Tamai, Hanako: 1 article (02/2019)
4.	Tamura, Maki: 1 article (02/2019)

Related Diseases

1.	Pain (Aches) 02/01/2019 - "Safety and efficacy of a combination of pethidine and levallorphan for pain relief during labor: An observational study." 02/01/2019 - "To evaluate the safety, effect on breastfeeding and efficacy of a combination of pethidine and levallorphan (Pethilorfan) for pain relief during labor. " 08/01/1986 - "Furthermore, it is estimated that a receptor exists which is antagonized by N-methyl levallorphan but not by naloxone and that there is a system of hyperalgesia by EKC and morphine in pain modulation."
2.	Ischemic Stroke 09/01/1985 - "The findings indicate that levallorphan may have a temporary improving effect on neurological deficits in acute ischemic stroke. " 09/01/1985 - "Reversal of neurological deficits by levallorphan in patients with acute ischemic stroke." 09/01/1985 - "This study was conducted to examine the effect of the intramuscular injection of levallorphan tartrate (1.0 mg), a mixed agonist-antagonist opiate, on the neurological signs, symptoms, and vital signs in 19 patients with acute ischemic stroke. "
3.	Respiratory Insufficiency (Respiratory Failure) 06/01/1978 - "The use of antagonists with agonist properties to reverse respiratory depression due to a morphinomimetic drug is not justified and so naloxone should supplant levallorphan." 01/01/1957 - "[Respiratory failure after therapeutic morphine administration and relief by levallorphan]." 06/01/1954 - "Preliminary observations on the effect of levallorphan on respiratory depression and analgesia of levorphan in man." 10/01/1955 - "Effect of levallorphan and nalorphine upon barbiturate-induced respiratory depression in rats." 11/01/1953 - "Effect of levallorphan tartrate upon opiate induced respiratory depression."
4.	Diarrhea 03/01/1978 - "In a physical dependence-producing test, the rats fed ifenprodil never manifested withdrawal signs such as diarrhea, "wet shakes", sudden loss of body weight as in the levallorphan precipitation test. " 08/01/1975 - "Levallorphan (0.5, 1, 3 and 5 mg/kg, s.c.) administered to morphine dependent rats had dose-dependent effects on the intensity of abstinence symptoms (e.g., diarrhea, piloerection and wet shakes phenomena), maximal decrease in body weight and duration of decreased body weight. " 12/15/1986 - "injection of either naloxone, 25 mg/kg, or the peripherally selective opioid antagonist SR 58002 C (N-methyl levallorphan mesilate), 75 mg/kg. Naloxone provoked jumping and diarrhea in all the animals; mice challenged with SR 58002 C presented no significant jumping but a high frequency of withdrawal diarrhea. "
5.	Body Weight (Weight, Body) 03/01/1978 - "In a physical dependence-producing test, the rats fed ifenprodil never manifested withdrawal signs such as diarrhea, "wet shakes", sudden loss of body weight as in the levallorphan precipitation test. " 08/01/1975 - "Levallorphan (0.5, 1, 3 and 5 mg/kg, s.c.) administered to morphine dependent rats had dose-dependent effects on the intensity of abstinence symptoms (e.g., diarrhea, piloerection and wet shakes phenomena), maximal decrease in body weight and duration of decreased body weight. " 05/01/1975 - "(e) When levallorphan (5 mg/kg, s.c.) was administered to both pethidine and morphine dependence rats, the maximal decrease in body weight was less than that in morphine dependent rats. "

Related Drugs and Biologics

1.	Meperidine (Pethidine)
2.	pethilorfan
3.	tartaric acid (tartrate)
4.	Opiate Alkaloids
5.	Morphine (MS Contin)
6.	Naloxone (Narcan)
7.	Nalorphine
8.	Narcotic Antagonists (Opioid Antagonists)
9.	Nalbuphine (Nubain)
10.	Levorphanol (Levo-Dromoran)

Related Therapies and Procedures

1.	Intramuscular Injections
2.	Analgesia
3.	Intravenous Administration
4.	Intra-Arterial Infusions
5.	Anesthesia