|1.||Haribabu, Bodduluri: 13 articles (01/2015 - 02/2004)|
|2.||Haeggström, Jesper Z: 13 articles (08/2014 - 06/2002)|
|3.||Yokomizo, Takehiko: 12 articles (01/2015 - 08/2002)|
|4.||Kim, Jae-Hong: 9 articles (12/2015 - 03/2002)|
|5.||Bäck, Magnus: 9 articles (09/2015 - 07/2004)|
|6.||Luster, Andrew D: 9 articles (01/2015 - 10/2003)|
|7.||Shimizu, Takao: 9 articles (01/2015 - 08/2002)|
|8.||Peters-Golden, Marc: 8 articles (12/2015 - 09/2006)|
|9.||Cunha, Fernando Q: 8 articles (01/2015 - 07/2003)|
|10.||Barnes, Peter J: 8 articles (01/2011 - 08/2002)|
05/01/2015 - "Application of leukotriene B4 and reflectance confocal microscopy as a noninvasive in vivo model to study the dynamics of skin inflammation."
12/01/2006 - "The aims of this study are to measure LTB4 levels in EBC collected in two challenges characterised by a strong neutrophilic airway inflammation and to compare LTB4 levels in EBC with levels in sputum and saliva. "
10/01/2003 - "These studies indicate that LTB4 production by activated peripheral leukocytes could be important for the recruitment of effector CD8+ T cells to sites of inflammation."
01/01/2000 - "The results of this study indicate that CsA therapy does not have a significant effect on GCF LTB4 and PAF levels and that gingival inflammation seems to be the main reason for their elevation. "
05/01/1992 - "In light of these and prior studies, urinary thromboxane may be a general marker of glomerular inflammation and leukotriene B4 may be a more specific index of acute inflammation."
01/01/2014 - "Inhibition of 5-LO by 5-ASA disrupts this pathway and supports the concept that LTB4 activation of TRPV1 plays a role in toxin A colitis. "
01/01/2014 - "Thus, toxin A stimulates colonic LTB4 resulting in activation of TRPV1, release of SP, and colitis. "
01/01/2004 - "Imaging of experimental colitis with a radiolabeled leukotriene B4 antagonist."
01/01/1992 - "These results suggest that inhibitors of colonic prostaglandin synthesis can markedly exacerbate colitis, and that this effect is unrelated to alterations in colonic leukotriene B4 synthesis. "
01/01/1992 - "Exacerbation of experimental colitis by nonsteroidal anti-inflammatory drugs is not related to elevated leukotriene B4 synthesis."
|3.||Asthma (Bronchial Asthma)
07/01/2009 - "These studies suggest that LTB4 may contribute to asthma pathophysiology. "
07/01/1989 - "This study provides evidence for a role for LTs in the airways of subjects with day-to-day asthma and suggests that LTB4 may also be involved in the recruitment of granulocytes into the lung in patients with CFA."
11/01/2015 - "Urinary measurement of LTB4 may be an interesting and non-invasive option to assess control of asthma. "
04/01/2014 - "Sputum LTB4 (P = 0.013), and plasma 11βPGF2α (P = 0.032), concentrations, respectively, were increased in smokers with asthma compared with healthy smokers. "
02/01/2014 - "Despite suppressing the target mediator LTB4, FLAP inhibitor GSK2190915 had no short-term effect on sputum cell counts or clinical endpoints in patients with asthma and sputum neutrophilia."
11/01/2003 - "Our data suggest an important role for NK1 receptor activation with consequent LTB4 release and eosinophil recruitment in a model of allergic pleurisy in the mouse. "
01/01/1991 - "3. In a rat pleurisy model, the administration of A-64077 (p.o., 2 hr pretreatment) caused a marked decrease in LTB4 levels measureable after ionophore stimulation at doses of 3 and 10 mg kg (67 and 96% inhibition, respectively). "
06/11/2009 - "Notably, 11a efficiently blocks 5-LO product formation in human whole blood assays (IC(50) = 0.83-1.6 microM) and significantly prevented leukotriene B(4) production in pleural exudates of carrageenan-treated rats, associated with reduced severity of pleurisy. "
10/01/1985 - "At present, very little is known of the stability of this compound in vivo; therefore, the present study was designed to determine the half-life and metabolic fate of radiolabeled LTB4 during a 2-hr intrapleural incubation in rats with acute carrageenan pleurisy. "
03/01/2004 - "We show here that type VI iPLA2 drives the onset of acute pleurisy through the synthesis of PGE2, LTB4, PAF, and IL-1beta. "
11/01/1990 - "The objectives of this study were to determine whether (a) leukotriene B4 is produced in the gut mucosa during ischemia and reperfusion, and (b) inhibition of leukotriene B4 attenuates granulocyte infiltration into the postischemic intestinal mucosa. "
08/01/2005 - "The content of leukotriene B (4) (LTB (4)) in the liver increased during ischemia. "
03/01/1999 - "Animals subjected to two insults of ischemia-reperfusion demonstrated significantly less mucosal injury than animals undergoing one episode of ischemia and 2 h of reperfusion, despite increased neutrophil infiltration, leukotriene B4, and activated systemic neutrophils. "
07/01/1995 - "These data indicate that 8R,15S-diHETE interacts with stereospecific receptors to sensitize, whereas LTB4 reduces, the response of abdominal visceral afferents to ischemia. "
01/01/1994 - "Tissue levels of LTB4 in the brain increased during 30 min ischemia and remained high until 5 min after reperfusion (p < 0.01) returning at 15 min reperfusion to the control level. "
|6.||Thromboxane A2 (A2, Thromboxane)
|7.||6-Ketoprostaglandin F1 alpha (6 Ketoprostaglandin F1 alpha)
|9.||Arachidonate 5-Lipoxygenase (5 Lipoxygenase)
|10.||Arachidonic Acid (Vitamin F)
|1.||Renal Dialysis (Hemodialysis)