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Progressive Multifocal Leukoencephalopathy

An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7)
Also Known As:
Leukoencephalopathy, Progressive Multifocal; JC Polyomavirus Encephalopathy; Encephalopathies, JC Polyomavirus; Encephalopathy, JC Polyomavirus; JC Polyomavirus Encephalitis; Leukoencephalopathies, Progressive Multifocal; Multifocal Leukoencephalopathies, Progressive; Multifocal Leukoencephalopathy, Progressive; Progressive Multifocal Leukoencephalopathies; Encephalitis, JC Polyomavirus
Networked: 1508 relevant articles (91 outcomes, 74 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Multiple Sclerosis
2. Acquired Immunodeficiency Syndrome (AIDS)
3. Relapsing-Remitting Multiple Sclerosis
4. Infections
5. Crohn Disease (Crohn's Disease)

Experts

1. Gold, Ralf: 29 articles (01/2021 - 12/2008)
2. Berger, Joseph R: 28 articles (08/2021 - 07/2005)
3. Wattjes, Mike P: 28 articles (01/2021 - 10/2013)
4. Nakamichi, Kazuo: 27 articles (12/2021 - 02/2010)
5. Koralnik, Igor J: 27 articles (09/2021 - 01/2002)
6. Killestein, Joep: 24 articles (01/2022 - 09/2010)
7. Saijo, Masayuki: 21 articles (12/2021 - 02/2010)
8. Capra, Ruggero: 19 articles (05/2021 - 09/2013)
9. Major, Eugene O: 18 articles (01/2021 - 01/2003)
10. Hartung, Hans-Peter: 17 articles (01/2021 - 02/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Progressive Multifocal Leukoencephalopathy:
1. Natalizumab (Tysabri)FDA Link
2. Mefloquine (Lariam)FDA LinkGeneric
3. IntegrinsIBA
4. Monoclonal AntibodiesIBA
5. Mirtazapine (Rexer)FDA LinkGeneric
6. nitazoxanide (NTZ)FDA Link
7. DNA (Deoxyribonucleic Acid)IBA
8. AntibodiesIBA
9. Cidofovir (Vistide)FDA Link
10. N-acetyltalosaminuronic acid (NAT)IBA

Therapies and Procedures

1. Therapeutics
2. Highly Active Antiretroviral Therapy (HAART)
3. Aftercare (After-Treatment)
4. Biological Therapy
5. Peripheral Blood Stem Cell Transplantation (Peripheral Stem Cell Transplantation)