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Mast-Cell Leukemia (Leukemia, Mast Cell)

A form of systemic mastocytosis (MASTOCYTOSIS, SYSTEMIC) characterized by the presence of large numbers of tissue MAST CELLS in the peripheral blood without skin lesions. It is a high-grade LEUKEMIA disease with bone marrow smear of >20% MAST CELLS, multi-organ failure and a short survival.
Also Known As:
Leukemia, Mast Cell; Leukemia, Mast-Cell; Leukemias, Mast-Cell; Mast Cell Leukemia; Mast-Cell Leukemias
Networked: 70 relevant articles (3 outcomes, 4 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
2. Mastocytosis (Mast-Cell Disease)
3. Myeloid Leukemia (Leukemia, Myelocytic)
4. Testicular Neoplasms (Testicular Cancer)
5. Systemic Mastocytosis

Experts

1. Valent, Peter: 6 articles (10/2013 - 01/2002)
2. Pardanani, Animesh: 5 articles (03/2015 - 01/2002)
3. Sperr, Wolfgang R: 4 articles (10/2007 - 01/2002)
4. Horny, Hans-Peter: 3 articles (10/2013 - 01/2002)
5. Neckers, Len: 3 articles (05/2008 - 02/2004)
6. Pan, Jingxuan: 2 articles (05/2014 - 01/2010)
7. Reiter, Andreas: 2 articles (10/2013 - 09/2013)
8. Sotlar, Karl: 2 articles (10/2013 - 10/2005)
9. Kajiguchi, Tomohiro: 2 articles (05/2008 - 10/2005)
10. Lechner, Klaus: 2 articles (03/2004 - 01/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Mast-Cell Leukemia:
1. masitinibIBA
2. 17-(allylamino)-17-demethoxygeldanamycin (17AAG)IBA
3. Immunoglobulin E (IgE)IBA
4. Chemokine CCL5IBA
5. Macrophage Inflammatory ProteinsIBA
6. Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA
7. ChemokinesIBA
8. Interleukin-8 (Interleukin 8)IBA
9. CytokinesIBA
10. QuercetinIBA

Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Stem Cell Transplantation
3. Hematopoietic Stem Cell Transplantation
4. Liver Transplantation
5. PUVA Therapy