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Leucyl Aminopeptidase (S, Peptidase)

A zinc containing enzyme of the hydrolase class that catalyzes the removal of the N-terminal amino acid from most L-peptides, particularly those with N-terminal leucine residues but not those with N-terminal lysine or arginine residues. This occurs in tissue cell cytosol, with high activity in the duodenum, liver, and kidney. The activity of this enzyme is commonly assayed using a leucine arylamide chromogenic substrate such as leucyl beta-naphthylamide.
Also Known As:
S, Peptidase; Peptidase S; Leucine Aminopeptidase; L-Leucylnaphthylamidase; Methoxyleucine Aminopeptidase; Zinc-Manganese-Leucine Aminopeptidase; Aminopeptidase, Cytosol; Aminopeptidase, Leucine; Aminopeptidase, Leucyl; Aminopeptidase, Methoxyleucine; Aminopeptidase, Zinc-Manganese-Leucine; Zinc Manganese Leucine Aminopeptidase; Cytosol Aminopeptidase
Networked: 288 relevant articles (2 outcomes, 21 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Walling, Linda L: 6 articles (06/2014 - 03/2002)
2. Dalton, John P: 3 articles (01/2010 - 01/2006)
3. Trenholme, Katharine R: 3 articles (01/2010 - 01/2006)
4. Stack, Colin M: 3 articles (01/2010 - 01/2006)
5. Gardiner, Donald L: 3 articles (01/2010 - 01/2006)
6. Hattori, Akira: 3 articles (03/2006 - 08/2003)
7. Tsujimoto, Masafumi: 3 articles (03/2006 - 08/2003)
8. Kikkawa, Fumitaka: 3 articles (01/2005 - 08/2003)
9. Ino, Kazuhiko: 3 articles (01/2005 - 08/2003)
10. Shibata, Kiyosumi: 3 articles (01/2005 - 08/2003)

Related Diseases

1. Infection
2. Fascioliasis
3. Neoplasms (Cancer)
4. Urologic Diseases (Urinary Tract Disease)
5. Jaundice

Related Drugs and Biologics

1. Peptide Hydrolases (Proteases)
2. Cathepsin L
3. Alkaline Phosphatase
4. Acid Phosphatase
5. Enzymes
6. Oxidoreductases
7. Isoenzymes
8. beta 2-Microglobulin (beta 2 Microglobulin)
9. Hexosaminidases (Hexosaminidase)
10. Transferases

Related Therapies and Procedures

1. Transplants (Transplant)
2. Transplantation (Transplant Recipients)
3. Lithotripsy (Extracorporeal Shockwave Lithotripsy)
4. Ligation
5. Brachytherapy