|2.||Sarcoma (Soft Tissue Sarcoma)
|4.||Neoplasm Metastasis (Metastasis)
|1.||Hensley, Martee L: 11 articles (04/2015 - 06/2002)|
|2.||Le Cesne, Axel: 10 articles (04/2015 - 11/2005)|
|3.||Yaegashi, Nobuo: 9 articles (10/2014 - 06/2005)|
|4.||Blessing, John A: 9 articles (10/2014 - 01/2002)|
|5.||van de Rijn, Matt: 8 articles (08/2015 - 10/2003)|
|6.||Lee, Cheng-Han: 7 articles (08/2015 - 06/2009)|
|7.||Blay, Jean-Yves: 7 articles (01/2014 - 08/2006)|
|8.||Pollock, Raphael E: 7 articles (07/2013 - 04/2002)|
|9.||Coindre, Jean-Michel: 7 articles (04/2013 - 08/2006)|
|10.||Espinosa, Inigo: 6 articles (08/2015 - 06/2009)|
06/01/2012 - "We describe one case of a 41-year-old woman with PRES under treatment for leiomyosarcoma because of the probable association with gemcitabine. "
01/01/2008 - "Gemcitabine-induced progressive and sustained tumour response in a patient with multi-drug resistant uterine leiomyosarcoma."
12/01/2003 - "Gemcitabine appears to be an agent with activity, particularly in patients with leiomyosarcomas. "
10/01/2003 - "Unusual response to second-line single-agent gemcitabine in locally advanced primary leiomyosarcoma of the lung: a case report."
02/01/2004 - "Phase II trial of gemcitabine as second-line chemotherapy of uterine leiomyosarcoma: a Gynecologic Oncology Group (GOG) Study."
|2.||trabectedin (ecteinascidin 743)IBA
12/01/2011 - "The aim of this retrospective analysis was to look at the efficacy of trabectedin in the subgroup of uterine leiomyosarcoma. "
01/01/2012 - "A phase II evaluation of trabectedin in the treatment of advanced, persistent, or recurrent uterine leiomyosarcoma: a gynecologic oncology group study."
04/01/2015 - "Trabectedin has shown activity in pretreated leiomyosarcoma. "
01/01/2015 - "Long-lasting activity of trabectedin in refractory uterine leiomyosarcoma: a case report."
01/01/2015 - "Management Strategies in Advanced Uterine Leiomyosarcoma: Focus on Trabectedin."
|3.||Doxorubicin (Adriamycin)FDA LinkGeneric
03/01/2005 - "The dose and schedule of liposomal doxorubicin employed in this trial showed no advantage over historical results with doxorubicin in the treatment of uterine leiomyosarcoma."
03/01/2005 - "Phase II evaluation of liposomal doxorubicin (Doxil) in recurrent or advanced leiomyosarcoma of the uterus: a Gynecologic Oncology Group study."
12/01/2013 - "Complete regression of primary epicardial leiomyosarcoma with single agent doxorubicin in an elderly patient."
06/01/2008 - "Doxorubicin-based treatment is standard therapy for metastatic uterine leiomyosarcoma. "
05/01/2001 - "Histological subtypes were evenly matched, 33% were leiomyosarcoma (CAELYX: 18; doxorubicin: 13). "
|4.||docetaxel (Taxotere)FDA Link
03/15/2012 - "Two patients with gynecological malignancies (uterine leiomyosarcoma and ovarian adenocarcinoma) experienced severe hypersensitivity reactions with docetaxel, including flushing, numbness, sharp radiating pain, severe nausea and vomiting, apnea, and unresponsiveness. "
01/01/2012 - "Both single-agent gemcitabine and gemcitabine plus docetaxel were found to be effective second-line therapies for leiomyosarcomas, with a 3-month progression-free survival rate of 40% for LMS with both uterine and nonuterine sites of origin. "
01/01/2011 - "In this article, we also describe an immunohistochemical approach to diagnose leiomyosarcoma and the efficacy of a gemcitabine and docetaxel regimen."
01/01/2015 - "This study demonstrates gemcitabine and docetaxel to be active in locally advanced/metastatic leiomyosarcoma in the first line setting. "
01/01/2012 - "This study aimed to evaluate the efficacy and toxicity of single-agent gemcitabine versus gemcitabine plus docetaxel as second-line therapy in patients with uterine and nonuterine leiomyosarcoma (LMS). "
12/01/1994 - "Additionally, this experience and a review of the literature, suggest that ifosfamide has little activity against gastrointestinal leiomyosarcomas. "
02/01/1992 - "These results indicate that ifosfamide has modest activity in patients with advanced or recurrent leiomyosarcomas of the uterus."
02/01/1992 - "The purpose of this study was to evaluate the activity of ifosfamide (isophosphamide) in patients with advanced or recurrent leiomyosarcoma not previously exposed to chemotherapy. "
10/01/2000 - "In this article we report the first case of methemoglobinemia in a patient with metastatic uterine leiomyosarcoma, after infusion of ifosfamide chemotherapy. "
03/01/2001 - "Further evaluations of this novel ifosfamide-epirubicin schedule are not warranted, even if the HD-IFO regimen could be taken forward specifically for leiomyosarcomas in a phase II trial."
|6.||Paclitaxel (Taxol)FDA LinkGeneric
04/01/2003 - "The purpose of this phase II trial was to evaluate the efficacy of intravenous paclitaxel in patients with recurrent or advanced leiomyosarcoma of the uterus. "
04/01/2003 - "Evaluation of paclitaxel in previously treated leiomyosarcoma of the uterus: a gynecologic oncology group study."
09/01/1999 - "Phase II trial of paclitaxel in leiomyosarcoma of the uterus: a gynecologic oncology group study."
09/01/1999 - "With the dose and schedule tested, paclitaxel has limited activity in patients with uterine leiomyosarcoma. "
09/01/1999 - "The aim of this study was to determine the activity of paclitaxel in chemotherapy-naive patients with advanced or recurrent uterine leiomyosarcoma. "
|7.||temozolomide (Temodar)FDA LinkGeneric
11/01/2003 - "Temozolomide at the dose schedule employed in the current study was tolerated well and had modest activity against previously treated unresectable or metastatic leiomyosarcoma of both uterine and nonuterine origin."
01/01/2010 - "Temozolomide is an easily administered, well-tolerated chemotherapeutic option in advanced or recurrent uterine leiomyosarcomas with a reasonable response rate. "
01/01/2010 - "From 1999 to 2008, 9 cases of leiomyosarcoma were diagnosed; 6 patients received temozolomide. "
01/01/2010 - "All patients with advanced or recurrent uterine leiomyosarcoma who received temozolomide during treatment were retrospectively identified. "
07/01/2005 - "Further investigation of temozolomide in leiomyosarcoma patients is warranted."
04/01/2007 - "A 26-year-old man diagnosed with metastatic rectal leiomyosarcoma was treated with intravenous bevacizumab 5 mg/kg and received a total of 3 doses at 2 week intervals. "
09/01/2007 - "Bevacizumab was well-tolerated and displayed promising anti-neoplastic activity in patients with endometrial cancer and uterine leiomyosarcoma."
04/01/2007 - "Interstitial nephritis secondary to bevacizumab treatment in metastatic leiomyosarcoma."
08/01/2011 - "Complete remission of recurrent and refractory uterine epithelioid leiomyosarcoma using weekly administration of bevacizumab and temozolomide."
04/01/2015 - "Randomized phase III trial of gemcitabine plus docetaxel plus bevacizumab or placebo as first-line treatment for metastatic uterine leiomyosarcoma: an NRG Oncology/Gynecologic Oncology Group study."
10/01/2010 - "Examples are trabectedin in lyposarcoma and leiomyosarcoma, and taxanes in angiosarcoma."
03/01/2014 - "In addition to these compounds there is evidence of efficacy of new drugs such as taxanes in angiosarcoma, gemcitabine+taxanes combination in leiomyosarcomas, trabectedin in leiomyosarcomas and liposarcomas with an extremely high activity in myxoid liposarcoma. "
06/01/2014 - "Examples of more specific treatment options include taxanes in angiosarcoma, and trabectedin in leiomyosarcoma, liposarcoma and undifferentiated pleomorphic sarcoma. "
06/01/2014 - "Since peculiar chemosensitivity towards alternative drugs was described for different metastatic subtypes in second or further lines, the modern concept of 'histology-driven chemotherapy' has been accepted and employed: gemicitabine ± dacarbazine, trabectedin and taxanes used respectively in patients with leiomyosarcoma, solitary fibrous tumor, myxoid/round cell liposarcoma, angiosarcoma. "
02/01/2010 - "Apart from Ewing's sarcoma family tumor and rhabdomyosarcoma, there is increasing specialization of chemotherapy according to histological subtype, such as the use of taxanes for angiosarcoma, gemcitabine and docetaxel for leiomyosarcoma, and trabectedin for leiomyosarcoma and liposarcoma, especially the myxoid/round cell variant. "
|10.||Estrogens (Estrogen)FDA Link
01/01/2013 - "A 55-60 year age group female presented with an estrogen receptor positive metastatic retroperitoneal leiomyosarcoma (LMS). "
07/01/2011 - "Two (29%) of 7 BMP2⁺ leiomyosarcomas were estrogen receptor+, compared with 5 (50%) of 10 BMP2⁻ leiomyosarcomas, a statistically insignificant difference (P=0.62). "
12/01/2004 - "The authors have noted anecdotal cases of extrauterine leiomyosarcomas (LMS) with estrogen receptor (ER) and progester-one receptor (PR) immunoreactivity. "
05/01/2001 - "Syrian hamsters treated with estrogen and androgen for 8 months develop leiomyosarcomas in the vas deferens. "
07/01/1993 - "The DDT1 MF2 smooth muscle cell line was derived from an estrogen/androgen-induced leiomyosarcoma arising in the hamster ductus deferens. "
|1.||Drug Therapy (Chemotherapy)
08/01/1997 - "Neoadjuvant chemotherapy could be helpful for the complete resection of advanced leiomyosarcoma."
06/01/2013 - "Well-designed and good-quality RCTs are required to investigate the efficacy of chemotherapy and quality of life in target patients with uterine leiomyosarcoma."
09/01/2012 - "We report here on a rare case of paratesticular leiomyosarcoma treated successfully with orichiectomy and additional systemic chemotherapy."
11/01/1998 - "Improvement in the prognosis of leiomyosarcoma may justify perioperative chemotherapy before and after radical surgical excision."
06/01/1991 - "Nonetheless, aggressive surgical excision followed by chemotherapy appears to have improved survival in these patients with primary cardiac leiomyosarcoma, as they are among the longest survivors reported."
08/01/2009 - "Multiple local treatments including RFA, radiotherapy, and resection were effective for the local control of metastatic lesions of adrenal leiomyosarcoma."
08/01/1995 - "[Leiomyosarcoma of the prostate: a case report of remission for 9 years by radiotherapy]."
05/01/1975 - "Leiomyosarcomas could not be eradicated easily by surgery, recurred frequently, did not respond well to radiotherapy, and carried a poor prognosis."
02/01/2011 - "This study was undertaken to analyze the outcomes associated with the use of neoadjuvant radiotherapy and IVC reconstruction in the treatment of IVC leiomyosarcoma. "
04/01/2015 - "Rectal leiomyosarcoma, late complication of pelvic radiotherapy."
|3.||Heterologous Transplantation (Xenotransplantation)
09/01/2002 - "The objective was to test the efficacy of high-intensity focused ultrasound (HIFU) for treatment of uterine leiomyosarcoma in a Xenograft nude mouse model. "
08/26/2014 - "Tumour growth in leiomyosarcoma xenografts was dramatically inhibited by the treatment. "
04/01/2007 - "We set out to test the feasibility of delivering AdFLAGp53 (replication incompetent adenovirus bearing FLAG-tagged wild-type p53) and Ad.hTC.GFP/E1a.RGD (a fiber-modified, replication selective oncolytic adenovirus) into human leiomyosarcoma xenografts by ILP. "
09/01/2002 - "Treatment of uterine leiomyosarcoma in a xenograft nude mouse model using high-intensity focused ultrasound: a potential treatment modality for recurrent pelvic disease."
08/01/1999 - "The first human pancreatic leiomyosarcoma xenograft (PZX-7) growing in immuno-suppressed mice is described and characterized."
|4.||Combination Drug Therapy (Combination Chemotherapy)
10/01/2011 - "Our case report illustrates the potential role of combination chemotherapy in the management of advanced leiomyosarcoma of the prostate. "
10/01/1988 - "The second patient presented with a perforated grade 2 leiomyosarcoma which was incompletely resected; he received combination chemotherapy with an initial good response, but eventually died from sarcomatosis 7 years after initial diagnosis. "
01/01/1992 - "A case report of a woman with perineal leiomyosarcoma who was cured by combination chemotherapy is presented, and the literature on chemotherapy of soft tissue is reviewed."
01/01/2014 - "Multimodal therapy with debulking surgery, combination chemotherapy and radiotherapy controlled a rapidly progressive retroperitoneal pleomorphic leiomyosarcoma. "
01/01/2014 - "This report describes a case of rapidly progressive retroperitoneal pleomorphic leiomyosarcoma that was favorably controlled by debulking surgery followed by combination chemotherapy and radiotherapy. "
06/01/2014 - "Adjuvant chemotherapy in stage I-II uterine leiomyosarcoma: a multicentric retrospective study of 140 patients."
12/01/2013 - "Does adjuvant chemotherapy improve survival for women with early-stage uterine leiomyosarcoma?"
07/01/2008 - "Careful follow up after the surgery for the uterine leiomyosarcoma is recommended because metastatic leiomyosarcoma possibly appears even after a long interval, and its progress can be so intensive that adjuvant chemotherapy is necessary if it can not be treated surgically alone."
05/01/2006 - "Pathological examination documented a grade II leiomyosarcoma of the inferior vena cava and the patient was given adjuvant chemotherapy (anthracycline). "
01/01/2006 - "Prognostic factors and impact of adjuvant chemotherapy for uterine leiomyosarcoma."