Legionellosis

10/01/1988 - "In this study, treatment of experimental legionellosis was improved, compared with previous publications, by early administration of antibiotics and increased dosage and duration."
10/01/1988 - "Comparative efficacy of five antibiotics on experimental airborne legionellosis in guinea-pigs."
02/01/2003 - "[Fundamental studies on legionellosis--the growth with in Acanthamoeba sp. and antibiotics susceptibility of Legionella spp. isolated from soil samples in Japan]."
10/01/2019 - "The wild-type MIC distributions presented in this article may be useful for a better detection of antibiotic resistance and can contribute to improvements in the choice of the antibiotic treatment of legionellosis."
10/01/2019 - "Additionally, wild-type minimum inhibitory concentration (MIC) distributions for eight antibiotics commonly used for the treatment of legionellosis were calculated from the isolates obtained. "

09/01/1993 - "We describe a case of successful therapy of a neonatal Legionellosis with Erythromycin. "
01/01/1990 - "A clinical suspicion of legionellosis, later confirmed by both serology and isolation of the microorganism, prompted initiation of high dose erythromycin intravenously. "
06/01/1986 - "[A case of legionellosis treated with erythromycin]."
02/01/1991 - "The relatively low mortality rate of the Legionella group, when compared to other series of nosocomial legionellosis, could be due to the standard use of erythromycin in the therapeutic approach to nosocomial-acquired pneumonia in our hospital."
01/01/1992 - "Our patient's pneumonia was cured with medical therapy including erythromycin and was the first case of microbiologically confirmed legionellosis in Korea."

01/01/1993 - "Quinolones, alone or in combination with other agents, have also shown promise in animal models of legionellosis and in limited clinical studies. "
11/01/1991 - "Role of the quinolones in the treatment of legionellosis."
06/01/1998 - "A comparative study on the efficacy of the new quinolone alatrofloxacin in the treatment of experimental legionellosis in guinea pigs."
09/01/2014 - "We performed a systematic review and meta-analysis of studies reporting data that allowed the comparison of quinolones versus macrolides in the treatment of proven legionellosis published from 1 January 1985 to 31 January 2013. "
07/01/2010 - "Macrolides remain the best empirical treatment of intracellular respiratory pathogens, although some observational studies suggest that quinolones may be superior for the treatment of legionellosis."

01/01/2022 - "A single intravenous dose of azithromycin might be a valuable treatment alternative for patients with legionellosis."
01/01/2022 - "Treatment of legionellosis including a single intravenous dose of 1.5 g azithromycin: 18-year experience at a tertiary care hospital."
01/01/2022 - "Due to recent safety concerns regarding fluoroquinolones and the potential medical and economic benefits, we investigated the efficacy of a single intravenous dose of 1.5 g azithromycin for the treatment of pulmonary legionellosis. "
01/01/2010 - "It is concluded that therapy with azithromycin and levofloxacin give good clinical effect leaving no systemic lesions in patients with legionellosis pneumonia."
02/01/2010 - "Azithromycin, clarithromycin, ciprofloxacin, and gemifloxacin were also effective for treating legionellosis."

04/01/1986 - "Efficacy of pefloxacin in comparison with erythromycin in the treatment of experimental guinea pig legionellosis."
11/01/1993 - "ofloxacin, pefloxacin) in the treatment of legionellosis."
05/01/1994 - "The substantial accumulation of pefloxacin in alveolar components (alveolar macrophages and epithelial lining fluid) endorses its use in the treatment of intracellular bacterial infections such as legionellosis; for these diseases, pefloxacin represents an alternative to the macrolide antibiotics."
10/01/1988 - "The efficacy of preventive and curative treatment of experimental airborne legionellosis in guinea-pigs was studied for erythromycin, rifampicin, minocycline, doxycycline and pefloxacin. "

09/18/2008 - "Since 1999, the awareness of legionellosis among physicians, the availability of a urinary antigen tests and more efficient early warning and communication systems improved the efficiency of legionellosis outbreak management. "
11/27/2023 - "Therefore, it is important to suspect legionellosis based on clinical information, even if a urine antigen test is negative."
03/01/2022 - "Urinary antigen tests (UATs) have been used for the early detection of legionellosis and have demonstrated moderate sensitivity and high specificity. "
03/01/2022 - "Diagnostic accuracy of urinary antigen tests for legionellosis: A systematic review and meta-analysis."
04/01/2020 - "Currently, diagnosis of legionellosis relies mainly on urinary antigen testing (UAT) for Legionella pneumophila serogroup 1 (Lp1). "

08/01/2009 - "Fluoroquinolone resistance has been poorly studied in Legionella pneumophila, an intracellular pathogen responsible for legionellosis. "
11/01/2002 - "In severe Legionellosis as well as independently of severity in nosocomial legionellosis and immunosuppressed patients, intravenous fluoroquinolones are first choice drugs. "
09/01/1992 - "These two investigational fluoroquinolones appear well suited for further in vivo study of legionellosis therapy."
01/01/2022 - "Due to recent safety concerns regarding fluoroquinolones and the potential medical and economic benefits, we investigated the efficacy of a single intravenous dose of 1.5 g azithromycin for the treatment of pulmonary legionellosis. "
11/01/2002 - "Macrolides and fluoroquinolones should be the drugs of choice for the treatment of established Legionellosis. "

01/01/1997 - "Although utility of beta-lactams in the treatment of legionnaire's disease could not be demonstrated, clinical cures of human legionellosis with imipenem have been reported. "
03/01/1992 - "The therapeutic failure of amoxicillin-clavulanic acid should stimulate further reports and studies on the efficacy against legionellosis of this drug and similar beta-lactam inhibitor combinations as well as other beta-lactamase-stable beta-lactams."
11/01/1994 - "Sparfloxacin among the fluoroquinolones and imipenem among the beta-lactams require further clinical studies for legionellosis therapy."

03/01/1996 - "The efficacy of a live Francisella tularensis vaccine strain to cause nonspecific immunity toward experimental legionellosis and listeriosis was studied. "
01/01/2002 - "Notifications in 2000 consisted of 28,341 bloodborne infections (32% of total), 24,319 sexually transmitted infections (27%), 21,303 gastrointestinal infections (24%), 6,617 vaccine preventable infections (7%), 6,069 vectorborne infections (7%), 2,121 other bacterial infections (legionellosis, meningococcal infection, leprosy and tuberculosis) (2%), 969 zoonotic infections (1%) and only one case of a quarantinable infection. "
08/01/1994 - "However, as determined in vaccine trial studies in the guinea pig model for legionellosis, the species-specific antigen OmpS proved much more effective than the genus-common Hsp60 antigen."

07/01/1988 - "Efficacy of spiramycin on experimental airborne legionellosis in guinea pigs."
07/01/1988 - "Spiramycin merits further study in experimental and human legionellosis."
07/01/1988 - "Comparison of spiramycin and erythromycin in the treatment of experimental guinea pig legionellosis."

01/01/2019 - "Further studies are needed to evaluate specific antimicrobial combinations for legionellosis therapy."
12/01/2016 - "The purpose of this study was to investigate the susceptibility of waterborne strains of Legionella to eight antimicrobials commonly used in legionellosis therapy. "
10/01/2015 - "The purpose of this study was to describe the susceptibility of environmental strains of Legionella spp. to 10 antimicrobials commonly used for legionellosis therapy. "
01/01/2018 - "Legionellosis' treatment failures have been recently reported showing the possibility of resistance development to traditional therapy, especially in healthcare related disease cases. "
01/01/2014 - "BALF results were obtained after their death and therapy for legionellosis was not initiated. "

10/30/2015 - "ABCs data during 2011–2013 showed that approximately 44% of patients with legionellosis required intensive care, and 9% died. "
03/01/2004 - "In particular intensive care patients are a risk group because of their high amount of immunocompromised patients with an increased risk of developing a Legionellosis. "
06/01/1995 - "[Severe legionellosis after abuse of anti-inflammatory drugs--diagnostic and intensive care aspects based on a case report]."
10/01/1995 - "Patients requiring intensive care are also at risk of nosocomial infections including legionellosis. "
06/01/1995 - "Based on the case report, fundamental aspects of diagnostics, antibiotic treatment, intensive-care treatment and prognosis of severe cases of legionellosis are discussed."

01/01/2017 - "In Japan, hot springs and public baths are the major sources of legionellosis. "
03/01/2007 - "[Largest outbreak of legionellosis associated with spa baths: comparison of diagnostic tests]."
06/01/2005 - "[The largest outbreak of legionellosis in Japan associated with spa baths: epidemic curve and environmental investigation]."
11/01/2023 - "Public baths are considered the primary cause of legionellosis infection in Japan. "

01/01/2020 - "We describe the use of extracorporeal life support (ECLS) for Legionellosis in the pediatric and adult populations and report complications, morbidity, and mortality by conducting a retrospective review of patients from the Extracorporeal Life Support Organization registry, including two cases at our pediatric institution. "
08/15/2021 - "Here, we describe a fatal case report of pulmonary legionellosis with acute respiratory distress syndrome (ARDS), sepsis, associated cutaneous manifestation, and extracorporeal membrane oxygenation in a full-term neonate. "

03/01/2016 - "Legionellosis in Transplantation."
02/01/1981 - "The risk of acquiring sporadic legionellosis was increased among males and persons 50 years or older; persons with renal disease necessitating dialysis or transplantation, with chronic bronchitis or emphysema, with diabetes mellitus, and with cancer (10 selected sites or types); persons who smoke; and persons being treated with immunosuppressive drugs. "