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Phosphatidylcholine-Sterol O-Acyltransferase (Lecithin Cholesterol Acyltransferase)

An enzyme secreted from the liver into the plasma of many mammalian species. It catalyzes the esterification of the hydroxyl group of lipoprotein cholesterol by the transfer of a fatty acid from the C-2 position of lecithin. In familial lecithin:cholesterol acyltransferase deficiency disease, the absence of the enzyme results in an excess of unesterified cholesterol in plasma. EC 2.3.1.43.
Also Known As:
Lecithin Cholesterol Acyltransferase; Acyltransferase, Lecithin Cholesterol; Cholesterol Ester Lysolecithin Acyltransferase; Phosophatidylcholine-Sterol Acyltransferase; Acyltransferase, Lecithin; Acyltransferase, Phosophatidylcholine-Sterol; Cholesterol Acyltransferase, Lecithin; O-Acyltransferase, Phosphatidylcholine-Sterol; Phosophatidylcholine Sterol Acyltransferase; Phosphatidylcholine Sterol O Acyltransferase; Lecithin Acyltransferase; Phosphatidylcholine:sterol O-acyltransferase
Networked: 397 relevant articles (8 outcomes, 30 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Ng, Dominic S: 7 articles (12/2015 - 04/2002)
2. Connelly, Philip W: 6 articles (06/2012 - 04/2002)
3. Calabresi, Laura: 5 articles (01/2012 - 06/2004)
4. Katoh, N: 5 articles (06/2001 - 01/2000)
5. Maguire, Graham F: 4 articles (06/2012 - 04/2002)
6. Franceschini, Guido: 4 articles (01/2012 - 06/2004)
7. Santamarina-Fojo, S: 4 articles (12/2001 - 02/2000)
8. Kuroda, Masayuki: 3 articles (08/2014 - 02/2011)
9. Bujo, Hideaki: 3 articles (08/2014 - 02/2011)
10. Schaefer, Ernst J: 3 articles (06/2014 - 08/2008)

Related Diseases

1. Lecithin Acyltransferase Deficiency (Lecithin:Cholesterol Acyltransferase Deficiency)
2. Atherosclerosis
3. Hyperlipidemias (Hyperlipidemia)
4. Proteinuria
5. Hypertriglyceridemia

Related Drugs and Biologics

1. Lipoproteins (Lipoprotein)
2. Apolipoprotein A-I (Apolipoprotein A1)
3. Triglycerides (Triacylglycerol)
4. Apolipoproteins E (ApoE)
5. Phospholipid Transfer Proteins
6. Scavenger Receptors (Scavenger Receptor)
7. ATP-Binding Cassette Transporters (ABC Transporters)
8. Sterol O-Acyltransferase
9. Apolipoprotein E4
10. Lipoprotein Receptors (Lipoprotein Receptor)

Related Therapies and Procedures

1. Fat-Restricted Diet (Diet, Fat Restricted)
2. Transplants (Transplant)
3. Renal Dialysis (Hemodialysis)
4. Caloric Restriction
5. Laparoscopic Cholecystectomy