HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Lactoylglutathione Lyase

An enzyme that catalyzes the interconversion of methylglyoxal and lactate, with glutathione serving as a coenzyme. EC 4.4.1.5.
Also Known As:
Glutathione Lyase, Lactoyl; Lyase, Lactoyl Glutathione; Lyase, Lactoylglutathione; Glyoxalase I; Lactoyl Glutathione Lyase; Methylglyoxalase; S-Lactoyl-glutathione methylglyoxal-lyase (isomerizing)
Networked: 178 relevant articles (6 outcomes, 24 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Takasawa, Ryoko: 6 articles (01/2021 - 07/2011)
2. Tanuma, Sei-Ichi: 6 articles (01/2021 - 07/2011)
3. Al-Balas, Qosay A: 5 articles (01/2022 - 01/2018)
4. Hollenbach, Marcus: 5 articles (10/2021 - 01/2017)
5. Suh, Kwang Sik: 5 articles (10/2021 - 01/2016)
6. Yoshimori, Atsushi: 5 articles (01/2021 - 07/2011)
7. Choi, Eun Mi: 5 articles (02/2019 - 01/2016)
8. Hassan, Mohammad A: 4 articles (01/2022 - 01/2018)
9. Al-Shar'i, Nizar A: 4 articles (03/2021 - 01/2018)
10. Shimada, Nami: 4 articles (12/2019 - 01/2016)

Related Diseases

1. Neoplasms (Cancer)
2. Body Weight (Weight, Body)
3. Inflammation (Inflammations)
4. Mitochondrial Diseases (Mitochondrial Disease)
10/04/2021 - "Pretreatment with spironolactone also increased the level of reduced GSH and the activity of glyoxalase I. MG induced mitochondrial dysfunction, but markers of mitochondrial biogenesis such as mitochondrial membrane potential, adenosine triphosphate, proliferator-activated receptor gamma coactivator 1α, and nitric oxide were significantly improved by treatment of spironolactone. "
02/01/2018 - "In addition, xanthohumol increased glyoxalase I activity, glutathione, heme oxygenase-1 and nuclear factor erythroid 2-related factor 2 levels in the presence of MG. Pretreatment with xanthohumol before MG exposure reduced MG-induced mitochondrial dysfunction. "
01/25/2016 - "Furthermore, honokiol increased the levels of Nrf2 and increased the levels of glutathione and the activity of glyoxalase I. Pretreatment with honokiol prior to MG exposure reduced MG-induced mitochondrial dysfunction and alleviated MG-induced reduction of nitric oxide and PGC1α levels, suggesting that honokiol may induce mitochondrial biogenesis. "
01/01/2018 - "Additionally bergenin increased glyoxalase I activity, glutathione, heme oxygenase-1 and nuclear factor erythroid 2-related factor 2 levels in the presence of MG. Pretreatment with bergenin before MG exposure reduced MG-induced mitochondrial dysfunction by preventing mitochondrial membrane potential dissipation, loss of adenosine triphosphate and reduced adenosine monophosphate-activated protein kinase. "
01/01/2022 - "We identified other apoptosis-inducing isoflavones with the ability to inhibit glyoxalase I. Dimeric acridone alkaloids, carbazole alkaloids, and coumarin and quinoline derivatives-all obtained mainly from plants in the family Rutaceae-induced apoptosis of HL-60 cells via the production of reactive oxygen species and mitochondrial dysfunction. "
5. Reperfusion Injury

Related Drugs and Biologics

1. Receptor for Advanced Glycation End Products
2. Nitric Oxide (Nitrogen Monoxide)
3. Adenosine Triphosphate (ATP)
4. Antioxidants
5. Sirtuin 1
6. Thiamine (Aneurin)
7. Spironolactone (Aldactone)
8. Enzymes
9. hydroxyacylglutathione hydrolase
10. Metformin (Glucophage)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Lenses
3. Therapeutics