Lactosylceramides

Glycosphingolipids which contain as their polar head group a lactose moiety bound in glycosidic linkage to the hydroxyl group of ceramide. Their accumulation in tissue, due to a defect in lactosylceramide beta-galactosidase, is the cause of lactosylceramidosis.

Also Known As:

Networked: 16 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Baker, Nathaniel L: 2 articles (03/2022 - 05/2019)
2.	Hammad, Samar M: 2 articles (03/2022 - 05/2019)
3.	Hunt, Kelly J: 2 articles (03/2022 - 05/2019)
4.	Klein, Richard L: 2 articles (03/2022 - 05/2019)
5.	Lopes-Virella, Maria F: 2 articles (03/2022 - 05/2019)
6.	Fan, Yao-Yun: 2 articles (04/2009 - 06/2008)
7.	Khoo, Kay-Hooi: 2 articles (04/2009 - 06/2008)
8.	Lin, Chi-Hung: 2 articles (04/2009 - 06/2008)
9.	Yu, Lung-Chih: 2 articles (04/2009 - 06/2008)
10.	Adamski, Jerzy: 1 article (12/2020)

Related Diseases

1.	Chronic Kidney Failure (Chronic Renal Failure) 01/01/2011 - "The inactivation in α-GLA in FD results in the accumulation of glycosphingolipids, including globosides and lactosylceramides, which manifests as several common pathologies including end-stage kidney disease. " 11/01/2018 - "To evaluate associations of plasma sphingolipids with intermediate cardiovascular outcomes (hypertension, left ventricular hypertrophy, and decreased ejection fraction), cardiovascular mortality, and all-cause mortality in patients with end-stage renal disease, we measured plasma levels of ceramides, glucosylceramides, and lactosylceramides from the family of sphingolipids in 368 incident hemodialysis patients enrolled in the Predictors of Arrhythmic and Cardiovascular Risk in End-Stage Renal Disease study. "
2.	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 05/01/2019 - "Our findings showed that decreased levels of long and very long lactosylceramides were able to predict the development of MA in type 1 diabetes. " 03/01/2022 - "We have previously shown that very long ceramides/lactosylceramides predicted the development of macroalbuminuria (MA) in type 1 diabetes and expanded our studies into type 2 diabetes. "
3.	Metabolic Syndrome (Dysmetabolic Syndrome X) 04/18/2023 - "A total of 84 participants, including normal-weight (NW) and obese subjects without (OB-SIMET-) and with (OB-SIMET+) metabolic syndrome, were included in the study, and sphingolipidomics, including ceramides (Cer), dihydroceramides (DHCer), hexosyl-ceramides (HexCer), lactosyl-ceramides (LacCer), sphingomyelins (SM) and GM3 ganglosides families, and sphingosine-1-phosphate (S1P) and its congeners, was performed in plasma. "
4.	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 11/01/2018 - "To evaluate associations of plasma sphingolipids with intermediate cardiovascular outcomes (hypertension, left ventricular hypertrophy, and decreased ejection fraction), cardiovascular mortality, and all-cause mortality in patients with end-stage renal disease, we measured plasma levels of ceramides, glucosylceramides, and lactosylceramides from the family of sphingolipids in 368 incident hemodialysis patients enrolled in the Predictors of Arrhythmic and Cardiovascular Risk in End-Stage Renal Disease study. "
5.	Hypertension (High Blood Pressure) 11/01/2018 - "To evaluate associations of plasma sphingolipids with intermediate cardiovascular outcomes (hypertension, left ventricular hypertrophy, and decreased ejection fraction), cardiovascular mortality, and all-cause mortality in patients with end-stage renal disease, we measured plasma levels of ceramides, glucosylceramides, and lactosylceramides from the family of sphingolipids in 368 incident hemodialysis patients enrolled in the Predictors of Arrhythmic and Cardiovascular Risk in End-Stage Renal Disease study. "

Related Drugs and Biologics

1.	Ceramides
2.	Sphingomyelins
3.	Sphingolipids
4.	Glucosylceramides (Glucocerebrosides)
5.	sphingosine 1-phosphate (sphingosine-1-phosphate)
6.	Lysophosphatidylcholines (Lysophosphatidylcholine)
7.	Lipids
8.	Glycosphingolipids
9.	Biomarkers (Surrogate Marker)
10.	Triglycerides (Triacylglycerol)

Related Therapies and Procedures

1.	Renal Dialysis (Hemodialysis)