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Labyrinth Diseases

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Pathological processes of the inner ear (LABYRINTH) which contains the essential apparatus of hearing (COCHLEA) and balance (SEMICIRCULAR CANALS).

Also Known As:

Ear Disease, Inner; Ear Diseases, Inner; Inner Ear Diseases; Labyrinth Disease; Inner Ear Disease

Networked: 128 relevant articles (4 outcomes, 19 trials/studies) for this Disease, Comments

Relationship Network

Disease Context: Research Results

Otorhinolaryngologic Diseases: 119
- Ear Diseases: 115
  - Labyrinth Diseases: 128

Related Diseases

1.	Tinnitus
2.	Vertigo (Positional Vertigo)
3.	Dizziness (Lightheadedness)
4.	Vascular Diseases (Vascular Disease)
5.	Sinusitis

Experts

1.	Tomasi, J P: 4 articles (09/2001 - 12/2000)
2.	Gersdorff, M: 4 articles (09/2001 - 12/2000)
3.	Deggouj, N: 4 articles (09/2001 - 12/2000)
4.	Boulassel, M R: 4 articles (09/2001 - 12/2000)
5.	Weisman, Michael H: 3 articles (06/2009 - 10/2003)
6.	Rauch, Steven D: 3 articles (06/2009 - 10/2003)
7.	Yoo, Taijune: 3 articles (01/2009 - 01/2003)
8.	Park, Rae-Kil: 3 articles (01/2009 - 09/2005)
9.	Du, Xiaoping: 3 articles (01/2009 - 01/2003)
10.	Nakagawa, Takayuki: 3 articles (03/2004 - 01/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Labyrinth Diseases:

1.	Pentoxifylline (Trental)FDA LinkGeneric 01/01/2002 - "Treatment of vascular inner ear disease in vascular patients with pentoxifylline: a controlled, randomized trial." 01/01/2002 - "Treatment of vascular inner ear disease with pentoxifylline: a 4-week, controlled, randomized trial." 01/01/2002 - "The efficacy of pentoxifylline (PXF) in vascular inner ear disease (VIED) was studied comparing PXF and placebo in a 4-week study; 60 patients with unilateral loss of hearing, vertigo, dizziness, tinnitus (analyzed with an analogue scale line), and cochlear flow reduction were included. " 01/01/2002 - "The efficacy of Pentoxifylline in vascular inner ear disease (VIED) was studied comparing PXF and placebo in a 4-week study; 40 patients with vascular disease and monolateral loss of hearing, vertigo, dizziness, tinnitus (analyzed with an analogue scale line), and cochlear flow reduction were included. " Order ALL the reference details at left...
2.	Proteins (Proteins, Gene)IBA 01/01/1997 - "The results in the present study with proteins extracted from guinea pig inner ear were consistent with our previous study using proteins from human inner ear, suggesting that the 28-kD protein may be a candidate for detecting autoimmune inner-ear disease." 01/01/1997 - "Sera from patients with various inner-ear diseases, especially Ménière's disease, were investigated by Western blot against guinea pig inner-ear proteins. " 02/01/2006 - "MATERIAL AND METHODS: Sera from 9 patients with DEH, 18 patients with profound unilateral juvenile hearing loss and 15 control volunteer without inner ear diseases were investigated by means of Western blot assay against rat inner ear proteins. " 01/01/1997 - "Of 45 patients, 24 (53%) with various inner-ear diseases had antibodies against inner-ear proteins, compared with 0 of 10 (0%) in control subjects without inner-ear diseases. " 01/01/1997 - "Antibodies against inner-ear proteins in the sera of patients with inner-ear diseases." Order ALL the reference details at left...
3.	SteroidsIBA 12/01/2003 - "These findings suggest that the intra-endolymphatic sac steroids could make regulatory effects on the inner ear AQP-3 expression via vestibular aqueduct and modulate the homeostasis of endolymphatic fluids, encouraging the possibility that the endolymphatic sac could be a therapeutic window for the inner ear disease." 03/01/2002 - "It is highly likely that this slow elimination is closely related to the therapeutic effect of steroids in inner ear diseases." 11/01/2006 - "Audiometry revealed recovered acoustic sensation in the right ear, from 50 dB to 20 dB, and in the left ear from 70 to 35 dB with 1,000 Hz. Topical ocular drug delivery of steroids may be effective for inner ear disease and sinusitis in patients with systemic side effects to oral steroids." 12/01/2006 - "Patients with autoimmune inner-ear disease (AIED) are treated with high doses of steroids in the short term when suffering an acute hearing loss. " 03/01/1998 - "BACKGROUND: Steroids are routinely used to treat inner ear pathologies, such as sudden sensorineural hearing loss and autoimmune inner ear disease. " Order ALL the reference details at left...
4.	Immunoglobulins (Immunoglobulin)IBA 11/01/1997 - "Immunoglobulin staining was conducted in cochlear tissue from the C3H/lpr autoimmune strain mouse to better understand the local immune processes underlying autoimmune inner ear disease. " 09/01/1997 - "Involvement of autoimmune mechanisms in sudden-onset, rapidly progressive, bilateral inner ear disease is supported by the following evidence: (1) the inner ear contains immune cells and mediators (immunoglobulins); (2) animal models demonstrate inner ear damage after immunization with inner ear tissue; (3) experimental autoimmune inner ear disease appears to be transferable with sensitized T cells; (4) human SNHL can occur in the context of systemic immunologic disease; (5) SNHL can be improved by immunosuppressive therapy; and (6) patients with SNHL demonstrate elevated immune responses to inner ear proteins/tissue preparations. " 12/01/1992 - "The sera of 21 patients with inner ear disease were examined for the presence of anticollagen and anticochlear antibodies; the sera were used to probe Western blots of purified human collagens II, IX, and XI, and cochlear protein extract with peroxidase-conjugated goat anti human polyvalent immunoglobulin as the second antibody. " Order ALL the reference details at left...
5.	Myelin P0 Protein (Myelin Protein Zero)IBA 08/01/2007 - "OBJECTIVE: To purify P0 protein from guinea pig's inner ear by preparative SDS-PAGE and to study the possible role it may play in the etiology of autoimmune inner ear disease. " 08/01/2007 - "OBJECTIVE: To purify P0 protein from guinea pig's inner ear by preparative SDS-PAGE and study the possible role it may play in the etiology of autoimmune inner ear disease. " 08/01/2007 - "CONCLUSION: P0 protein from guinea pigs in ner ear can be successfully purified by preparative SDS-PAGE and an animal model of experimental autoimmune inner ear disease induced by P0 protein was successfully established." 08/01/2007 - "[Animal model of experimental autoimmune inner ear disease induced by P0 protein purified from inner ear]" 08/01/2007 - "CONCLUSION: P0 protein from guinea pig's inner ear can be successfully purified by preparative SDS-PAGE and an animal model of experimental autoimmune inner ear disease induced by P0 protein is successfully established." Order ALL the reference details at left...
6.	AntigensIBA 02/01/1996 - "Guinea pig inner ear antigens: extraction and application to the study of human autoimmune inner ear disease." 03/01/2010 - "We describe 2 cases of bilateral Ménière disease with features resembling autoimmune inner ear disease in patients who were found to be carriers of human leukocyte antigen (HLA) B27. " 01/01/2009 - "Oral antigen tolerance may be used to treat autoimmune inner ear disease." 05/01/2004 - "Although immune-mediated inner ear disease was reported around 25 years ago, numerous attempts to identify the inner ear antigens have been performed. " 01/01/2002 - "Crude inner ear antigen (CIEAg) can induce autoimmune inner ear disease (AIED) although it is not known which subcomponent of CIEAg is involved. " Order ALL the reference details at left...
7.	AntibodiesIBA 05/01/2007 - "CONCLUSIONS: The sole presence of antibodies to myelin P0 may not be used as a marker of inner ear disease of autoimmune origin." 05/01/2004 - "This often leads to a clinical diagnosis of autoimmune inner ear disease, although it is not clear how these antibodies cause inner ear disease. " 09/01/2001 - "BACKGROUND: We and other groups have previously demonstrated that a 58-kDa protein extracted from guinea pig or bovine inner ear tissue is a target of antibodies in serum samples from some patients with autoimmune inner ear diseases. " 02/01/2001 - "These findings indicate that the sole presence of antibodies to myelin P0 in the sera of guinea pigs or patients suspected of having autoimmune inner ear diseases is unlikely to elicit auditory abnormalities and that additional factors are necessary for the pathogenic development of these disorders." 05/24/1995 - "These results show that antibodies in sera from patients with inner ear disease reacted with at least two polypeptide bands (30 and 58 kDa) of guinea pig inner ear extracts, and the 58 kDa antigenic epitope was not cochlea specific." Order ALL the reference details at left...
8.	Collagen Type II (Type II Collagen)IBA 01/01/1990 - "Type II collagen-induced inner ear disease: critical evaluation of the guinea pig model." 05/01/1988 - "The presence of type II collagen in these tissues is significant, since it has been postulated as an autoantigen in autoimmune inner ear disease." 09/01/1984 - "Thus, the presence of antibody against type II collagen in inner ear fluid may imply an immune injury mechanism in inner ear diseases." 09/01/1984 - "Antibody activity in perilymph from rats with type II collagen-induced autoimmune inner ear disease." 11/01/1988 - "This study examines the role of prostaglandins in type II collagen-induced inner ear disease. " Order ALL the reference details at left...
9.	GlucocorticoidsIBA 04/01/2008 - "If the variability in peak concentration and gradient is also present under clinical conditions, this may contribute to the heterogeneity of outcome that is observed after intratympanic application of glucocorticoids for various inner ear diseases." 04/01/2008 - "BACKGROUND: In recent years, intratympanically applied glucocorticoids are increasingly being used for the treatment of inner ear disease. " 09/01/2006 - "These results emphasis how GR activity modulates hearing sensitivity and its importance for the rationale use of glucocorticoids in inner ear diseases." 03/01/2003 - "BACKGROUND: Interest in glucocorticoids for topical treatment of inner ear diseases is increasing. " 03/01/2002 - "Although glucocorticoids are widely used to treat inner ear diseases, glucocorticoid concentration has never been determined in the cochlear tissue. " Order ALL the reference details at left...
10.	AutoantibodiesIBA 01/01/2001 - "Inner ear autoantibodies and their targets in patients with autoimmune inner ear diseases." 07/01/1997 - "Autoantibodies in inner ear disease." 12/01/1996 - "We have previously shown that a 30,000 Mr protein extracted from guinea pig inner ear tissue is recognized by autoantibodies present in the serum of patients suffering from autoimmune inner ear disease. " 05/24/1995 - "To define further the character of autoantibodies against the inner ear in patients with inner ear disease, Autoantibodies in sera from 82 patients with inner ear disease were investigated by immunoblotting. " 05/24/1995 - "Detection of inner ear disease autoantibodies by immunoblotting." Order ALL the reference details at left...

Therapies and Procedures

1.	Plasmapheresis 09/01/1997 - "OBJECTIVE: This study aimed to evaluate the outcome of long-term hearing benefits of plasmapheresis (PMP) in presumed autoimmune inner ear disease (AIED). " 09/01/1997 - "Plasmapheresis in autoimmune inner ear disease: long-term follow-up." 11/01/1989 - "Theoretical and practical implications for plasmapheresis in autoimmune inner ear disease." Order ALL the reference details at left...
2.	Transplantation (Transplant Recipients) 05/15/2004 - "In the present study, we investigated the potential use of human amniotic epithelial cells, proposed to possess pluripotential properties, as a source of transplantation therapy in inner ear disease. " Order ALL the reference details at left...
3.	Hemodilution 01/01/1992 - "Recent placebo-controlled clinical double-blind trials failed to confirm any beneficial effects of rheological and vasodilative drugs or hemodilution in treatment of inner ear diseases. " Order ALL the reference details at left...
4.	Drug Therapy (Chemotherapy) 02/01/2009 - "MRI may contribute to our understanding of inner ear diseases and may be a useful addition to intratympanic drug therapy in the management of inner ear diseases. " 03/01/2007 - "It is important for the development of intratympanic drug therapies for inner-ear diseases to investigate how the drugs enter and leave the inner ear." 01/01/2005 - "Round-window anatomical considerations in intratympanic drug therapy for inner-ear diseases." 11/01/2001 - "Autoimmune inner ear disease: steroid and cytotoxic drug therapy." 03/01/2000 - "The identification of neurotransmitters and their receptors in the human cochlea has implications for the pharmacotherapy of inner ear diseases." Order ALL the reference details at left...
5.	Tissue Therapy (Cell Therapy) 01/01/2005 - "Cell therapy for inner ear diseases." 03/01/2004 - "Application of cell therapy to inner ear diseases." Order ALL the reference details at left...

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