Kinins

A generic term used to describe a group of polypeptides with related chemical structures and pharmacological properties that are widely distributed in nature. These peptides are AUTACOIDS that act locally to produce pain, vasodilatation, increased vascular permeability, and the synthesis of prostaglandins. Thus, they comprise a subset of the large number of mediators that contribute to the inflammatory response. (From Goodman and Gilman's The Pharmacologic Basis of Therapeutics, 8th ed, p588)

Also Known As:

Networked: 2029 relevant articles (40 outcomes, 226 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bader, Michael: 45 articles (01/2022 - 01/2002)
2.	Couture, Réjean: 35 articles (01/2021 - 06/2003)
3.	Pesquero, João B: 35 articles (06/2019 - 01/2002)
4.	Chao, Julie: 23 articles (09/2014 - 01/2003)
5.	Chao, Lee: 23 articles (09/2014 - 01/2003)
6.	Calixto, João B: 22 articles (01/2020 - 07/2000)
7.	Pesquero, João Bosco: 19 articles (01/2020 - 04/2004)
8.	Bhoola, Kanti D: 18 articles (01/2020 - 04/2004)
9.	Figueroa, Carlos D: 16 articles (01/2020 - 07/2003)
10.	Campos, Maria M: 15 articles (08/2020 - 07/2000)

Related Diseases

1.	Inflammation (Inflammations) 05/18/2023 - "This study investigated the association between the bioregulation of kinin-mediated inflammation with the clinical, quality of life, and imaging characteristics (e.g. " 01/01/2011 - "Paralleling these studies, the kinin system emerged as a proteolytic mechanism that links oedematogenic inflammation to immunity. " 08/01/1997 - "The aim of this study was to investigate the kinin generation pathways in acute and chronic inflammation of the lower airways. " 05/01/1967 - "Studies on the mechanism of kinin formation in inflammation." 01/01/2023 - "Intrinsic coagulation also induces the contact-kinin pathway of inflammation. "
2.	Pain (Aches) 02/01/2023 - "In the past years, a wide range of preclinical studies has amounted to the literature reinforcing the need for an updated review about the participation of kinins and their receptors in pain disorders. " 02/01/2012 - "Because the overall contribution of kinins to painful processes remains unclear, the aim of this study was to analyze pain-related behaviors of mice unable to respond to kinins because of a lack of both B1 and B2 receptors. " 06/29/2010 - "This study aims at defining the role of microglial kinin B1R in diabetic pain neuropathy. " 02/01/2000 - "In this regard, results of the present study confirm that blocking kinin B1 receptors is a novel approach for treatment of inflammatory pain." 05/01/1997 - "Autoradiographic studies have demonstrated the presence of B2 kinin receptor binding sites in superficial laminae of the dorsal horn and a down-regulation of those receptors in rat models of pain injury. "
3.	Insulin Resistance 01/01/2012 - "However, exclusive expression of the kinin B(1) receptor in adipose tissue completely rescued the improved systemic insulin sensitivity phenotype of B(1) (-/-) mice. " 01/01/2012 - "Kinin B(1) receptor knockout mice (B(1) (-/-)) are leaner and exhibit improved insulin sensitivity. " 01/01/2017 - "Kininase 1 As a Preclinical Therapeutic Target for Kinin B1 Receptor in Insulin Resistance." 05/01/2014 - "These data do not support a role for the TK-kinin system, protective or deleterious, in the development of insulin resistance and diabetes." 03/01/2012 - "Kinin B(1) receptor (B(1) R) contributes to insulin resistance through a mechanism involving oxidative stress. "
4.	Ischemia 02/01/2015 - "Kinin receptors are potential therapeutic targets in limb ischemia in diabetes. " 02/01/2015 - "The role of kinins in limb ischemia in the setting of diabetes is not documented. " 04/01/2014 - "On the whole an activation of the kinin system during ischemia/reperfusion of brain plays mostly pathogenetic role making worse the flow of reperfusion period and aggravating a brain damage." 04/01/2014 - "It was determined that the activation of kinins' formation by tripsin has a detrimental effect during ischemia/reperfusion of brain, producing an early development of hypoperfusion in reperfusion period, aggravating a brain damage. " 04/01/2014 - "[Cerebral blood flow and damage markers during ischemia/reperfusion of brain against a background of modulation of the kinin system's activity]."
5.	Heart Failure 01/01/2016 - "Kinin B1 receptor blockade and ACE inhibition attenuate cardiac postinfarction remodeling and heart failure in rats." 11/01/2008 - "Vascular B1 kinin receptors in patients with congestive heart failure." 04/01/2005 - "The B1 kinin receptor does not have a major vasomotor or fibrinolytic role in patients with heart failure. " 05/01/2003 - "These findings may help us understand the role of kinins in the development of cardiac failure." 12/01/2000 - "The loss of kinin and NO control of mitochondrial respiration may contribute to the pathogenesis of heart failure."

Related Drugs and Biologics

1.	2,5-dichloro-4-bromophenol (B 2)
2.	Bradykinin
3.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
4.	Kallikreins (Kallikrein)
5.	Tissue Kallikreins (Tissue Kallikrein)
6.	Prostaglandins
7.	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
8.	Glucose (Dextrose)
9.	Type 1 Angiotensin Receptor
10.	Plasma Kallikrein

Related Therapies and Procedures

1.	Analgesia
2.	Therapeutics
3.	Drug Therapy (Chemotherapy)
4.	Anesthesia
5.	Ligation