|1.||Gibson, Gary E: 12 articles (12/2011 - 03/2002)|
|2.||Xu, Hui: 7 articles (11/2009 - 03/2002)|
|3.||Gibson, G E: 6 articles (03/2011 - 01/2000)|
|4.||Shi, Qingli: 5 articles (12/2011 - 03/2005)|
|5.||Blass, J P: 4 articles (03/2011 - 02/2000)|
|6.||Butterworth, Roger F: 4 articles (03/2009 - 05/2002)|
|7.||Starkov, Anatoly A: 3 articles (07/2013 - 03/2004)|
|8.||Beal, M Flint: 3 articles (01/2010 - 03/2004)|
|9.||Blass, John P: 3 articles (01/2010 - 01/2004)|
|10.||Calingasan, N Y: 3 articles (06/2008 - 01/2000)|
|1.||Alzheimer Disease (Alzheimer's Disease)
12/01/2011 - "The activity of the α-ketoglutarate dehydrogenase complex (KGDHC), a mitochondrial enzyme complex that mediates the oxidative decarboxylation of α-ketoglutarate in the TCA cycle, is reduced in Alzheimer's disease. "
01/01/2010 - "Many experiments in tissues from humans support the notion that oxidative modification of the alpha-ketoglutarate dehydrogenase complex (KGDHC) compromises neuronal energy metabolism and enhances ROS production in Alzheimer's Disease (AD). "
11/15/2004 - "Abundant biochemical evidence links deficient activity of mitochondrial alpha-ketoglutarate dehydrogenase with neuropathologically confirmed Alzheimer's disease (AD). "
09/01/2000 - "Brain metabolism and the activity of the alpha-ketoglutarate dehydrogenase complex (KGDHC), a mitochondrial enzyme, are diminished in brains from patients with Alzheimer's disease (AD). "
01/01/1999 - "The mitochondrial alpha-ketoglutarate dehydrogenase complex (KGDHC) is deficient in Alzheimer's disease (AD). "
|2.||Parkinson Disease (Parkinson's Disease)
02/01/1994 - "We report an immunohistochemical study of the mitochondrial alpha-ketoglutarate dehydrogenase complex (KGDHC) in the substantia nigra in Parkinson's disease. "
02/01/1994 - "An immunohistochemical study on alpha-ketoglutarate dehydrogenase complex in Parkinson's disease."
01/01/1998 - "Association between the gene encoding the E2 subunit of the alpha-ketoglutarate dehydrogenase complex and Parkinson's disease."
05/30/1995 - "Defects in complex I and alpha-ketoglutarate dehydrogenase (alpha-KGDH) occur in the substantia nigra in Parkinson's disease (PD). "
02/01/2002 - "An association between both Alzheimer disease and Parkinson s disease and the 2-oxoglutarate dehydrogenase gene has been reported. "
01/01/1990 - "The activity of alpha-ketoglutarate dehydrogenase and succinic dehydrogenase in readaptation after 15-day hypokinesia was within normal limits, whereas following 30-day hypokinesia it was enhanced on days 11-15. "
09/01/1989 - "Activity of alpha-ketoglutarate dehydrogenase (KGDH) and succinate dehydrogenase (SDH) decreased immediately after hypokinesia and remained lowered till day 18. "
01/01/1983 - "On hypokinesia days 30 and 45 the activity of succinate dehydrogenase (SDH) and alpha-ketoglutarate dehydrogenase (alpha-KGDH) decreased, that of cytoplasmatic malate dehydrogenases (MDH) slightly increased, and that of NADP ICDH declined. "
11/01/1982 - "The study of 165 rats exposed to 60-day hypokinesia demonstrated a decrease in the quantity of mitochondrial protein and a decline in the activity of mitochondrial forms of NADP-isocitrate dehydrogenase (NADP-ICDH) and NAD-malate dehydrogenase (NAD-MDH), as well as NAD-ICDH, succinate dehydrogenase (SDH) and alpha-ketoglutarate dehydrogenase (alpha-KGDH). "
10/01/2010 - "Interestingly, in MCF-7 cells, 24h hypoxia decreased OxPhos flux (4-6-fold), and 2-oxoglutarate dehydrogenase and glutaminase activities (3-fold), with no changes in respiratory complexes I and IV activities. "
10/01/2005 - "Differential requirements of calcium for oxoglutarate dehydrogenase and mitochondrial nitric-oxide synthase under hypoxia: impact on the regulation of mitochondrial oxygen consumption."
10/01/2005 - "It was the aim of this study to evaluate the effect of hypoxia (20-30 microM) on the calcium-dependent activation of 2-oxoglutarate dehydrogenase (or 2-ketoglutarate dehydrogenase; OGDH) and mitochondrial nitric-oxide synthase (mtNOS). "
|5.||Korsakoff Syndrome (Wernicke-Korsakoff Syndrome)
10/01/1993 - "Results of this study demonstrate significant reductions of TPP-dependent enzymes [pyruvate dehydrogenase complex, alpha-ketoglutarate dehydrogenase (alpha KGDH), and transketolase] in autopsied cerebellar vermis samples from alcoholic patients with the clinical and neuropathologically confirmed diagnosis of Wernicke-Korsakoff Syndrome (WKS). "
|3.||Succinate Dehydrogenase (Fumarate Reductase)
|4.||Malate Dehydrogenase (Dehydrogenase, Malate)
|5.||Pyruvate Dehydrogenase Complex (Dehydrogenase Complex, Pyruvate)