Keratosis Follicularis (Darier's Disease)

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221 relevant articles (17 outcomes, 23 trials/studies) found for this Disease

Description: A slowly progressive autosomal dominant disorder of keratinization characterized by pinkish-to-tan papules that coalesce to form plaques. These lesions become darker over time and commonly fuse, forming papillomatous and warty malodorous growths.

Also Known As:

Darier's Disease; Darier Disease; Dariers Disease; Disease, Darier; Disease, Darier's

Relationship Network

Disease Context: Research Results

Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 422

Inborn Genetic Diseases: 549

Genetic Skin Diseases: 10

Keratosis Follicularis: 221

Skin and Connective Tissue Diseases

Skin Diseases: 5944

Keratosis: 1109

Keratosis Follicularis: 221

Genetic Skin Diseases: 10

Keratosis Follicularis: 221

Related Diseases

1.	Keratosis Follicularis (Darier's Disease)
2.	Benign Familial Pemphigus (Hailey Hailey Disease)
3.	Lamellar Ichthyosis (Harlequin Ichthyosis)
4.	Pemphigus (Pemphigus Vulgaris)
5.	Ichthyosis (Xeroderma)

Experts

1.	Hovnanian, Alain: 5 articles (10/2006 - 09/2003)
2.	Dhitavat, Jittima: 3 articles (12/2003 - 09/2003)
3.	Leslie, Natalie: 3 articles (12/2003 - 09/2003)
4.	Takahashi, Hidetoshi: 2 articles (08/2006 - 08/2004)
5.	Daiho, Takashi: 2 articles (08/2006 - 08/2004)
6.	Ishida-Yamamoto, Akemi: 2 articles (08/2006 - 08/2004)
7.	Yamasaki, Kazuo: 2 articles (08/2006 - 08/2004)
8.	Miyauchi, Yuki: 2 articles (08/2006 - 08/2004)
9.	Iizuka, Hajime: 2 articles (08/2006 - 08/2004)
10.	Suzuki, Hiroshi: 2 articles (08/2006 - 08/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Keratosis Follicularis:

1.	Etretinate FDA Link 08/12/1981 - "It is concluded that Tigason is effective in Darier's disease." 01/01/1981 - "It is pointed out that with the development of Ro 10-9359, an efficient remedy for Darier's disease has become available for the first time." 06/01/1981 - "The efficacy of an aromatic retinoid, Tigason (etretinate), in the treatment of Darier's disease." 11/01/1982 - "Histochemical study of enzyme activities during etretinate treatment of Darier's disease." 01/01/1981 - "Treatment of Darier's disease with an oral aromatic retinoid (Ro 10-9359): a clinical and light and electron microscopic study." Order ALL the reference details at left...
2.	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/01/1973 - "Zosteriform keratosis follicularis cleared with topically applied vitamin A acid." 01/01/1987 - "In order to know if this susceptibility is due to abnormal phagocytosis and if this can revert by administration of retinoic acid (RA), blood monocyte-derived macrophages, from four individuals with Darier's disease were obtained prior and after administration of RA to determine in them morphological, cytochemical and phagocytic activity changes" 01/01/1987 - "Augmentation of the phagocytic activity of monocytes in patients with Darier's disease by the oral administration of retinoic acid]" 06/01/1981 - "An ointment containing 0.05% retinoic acid (RA) was applied to the anterior surface of the chest in a patient suffering from Darier's keratosis follicularis" 08/01/1978 - "Four patients with extensive keratosis follicularis (Darler's disease) showed excellent clinical response to the oral administration of a new aromatic derivative of retinoic acid (RO 10-9359)" Order ALL the reference details at left...
3.	Acitretin FDA Link 06/01/2001 - "Acitretin is effective in cutaneous disorders of keratinization (ichtyosis, palmo-plantar keratoderma, Darier's disease)" 01/01/2008 - "Two cases with Darier's disease were previously shown to be resistant to acitretin therapy, but improved after 6 months of treatment" 09/01/1989 - "The dose response relationship to acitretin in five patients with Darier's disease was investigated" 09/01/1989 - "Acitretin monotherapy in Darier's disease." 01/01/1988 - "Clinical and ultrastructural effects of acitretin in Darier's disease." Order ALL the reference details at left...
4.	Vitamin A (Retinol)FDA Link 05/01/1951 - "Very extensive Darier's disease, considerably relieved by the administration of synthetic vitamin A.]" 05/01/1951 - "Darier's disease considerably relieved by synthetic vitamin A.]" 11/01/1982 - "Three patients with Darier's disease were treated with 1 X 10(6) IU of orally administered vitamin A daily for 14 days" 11/01/1982 - "High-dose vitamin A therapy for Darier's disease." 06/01/1982 - "Darier's disease and vitamin A" Order ALL the reference details at left...
5.	tazarotene (Tazorac)FDA Link 01/01/2006 - "The good response that was obtained suggests that the use of "short contact" tazarotene could be useful in the treatment of linear Darier's disease." 01/01/2006 - "Linear Darier's disease successfully treated with 0.1% tazarotene gel "short-contact" therapy." 03/01/2000 - "Tazarotene is an important addition to the therapeutic possibilities in Darier disease." 09/01/1999 - "The treatment of Darier's disease with topical tazarotene." 05/01/1999 - "Tazarotene gel in childhood Darier disease." Order ALL the reference details at left...
6.	Cyclosporine (Ciclosporin)FDA LinkGeneric 01/01/2008 - "Vulval Darier's disease treated successfully with ciclosporin." 11/01/1994 - "Darier's disease: severe eczematization successfully treated with cyclosporin." 01/01/1993 - "Cyclosporine and Darier's disease]" Order ALL the reference details at left...
7.	adapalene (Differin)FDA Link 04/01/1999 - "Effective treatment of localized Darier's disease with adapalene 0.1% gel." 01/01/2001 - "Acral Darier's disease successfully treated with adapalene." 04/01/1999 - "A case of localized Darier's disease is presented that responded promptly and with no side effects to the topical application of adapalene 0.1% gel" Order ALL the reference details at left...
8.	Minocycline (Cyclops)FDA LinkGeneric 08/01/1994 - "Oral minocycline improved keratosis follicularis squamosa (Dohi) and related disorder: bacterial factors are possibly involved in abberant keratinization." 08/01/1994 - "Three cases of keratosis follicularis squamosa (Dohi) and one case of papillomatose confluente et reticulee were successfully treated with oral minocycline (50-100 mg/day)" Order ALL the reference details at left...
9.	Ascorbic Acid (Vitamin C)FDA LinkGeneric 07/01/2002 - "This result strongly suggests that sunscreen and ascorbic acid would be very helpful in preventing the aggravation of Darier's disease caused by sun exposure." 07/01/2002 - "Complete lesions of Darier's disease arose with repeated exposure of ultraviolet B (2,600 mJ/cm2 for 10 days), and sunscreen and topical ascorbic acid protected against its appearance" 07/01/2002 - "We artificially induced Darier's disease in a 47-year-old Korean man, and tested the protection afforded by sunscreen and topical ascorbic acid" 07/01/2002 - "Induction of Darier's disease by repeated irradiation by ultraviolet B; protection by sunscreen and topical ascorbic acid." Order ALL the reference details at left...
10.	Adenosine Triphosphatases (ATPase)IBA 01/01/2008 - "Darier's disease (DD), an autosomal dominant inherited disorder of the skin, arising due to mutations in the isoform 2 of the sarco (endo) plasmic reticulum Ca(2+) ATPase (SERCA2), exemplifies an anomaly of Ca(2+) signaling disturbances" 01/01/2008 - "The ATP2A2 gene encodes Ca2+-dependent ATPase, the dysfunction of which causes Darier disease" 08/11/2006 - "We examined possible defects of sarco(endo)plasmic reticulum Ca2+-ATPase 2b (SERCA2b) associated with its 51 mutations found in Darier disease (DD) pedigrees, i.e" 08/11/2006 - "Comprehensive analysis of expression and function of 51 sarco(endo)plasmic reticulum Ca2+-ATPase mutants associated with Darier disease." 02/15/2006 - "ATP2C1 inactivation also diminishes Darier disease keratinocyte viability, suggesting that compensatory ATP2C1 upregulation maintains viability and partially compensates for defective endoplasmic reticulum Ca2+-ATPase in Darier disease keratinocytes" Order ALL the reference details at left...

Therapies and Procedures

1.	Dermabrasion 02/01/1979 - "Five patients with cornifying Darier's disease were treated successfully by partial-thickness resection of the skin and dermabrasion down through the papillary dermis into the reticular dermis" 01/01/1979 - "Dermabrasion was carried out in 5 patients with severe Darier's disease" 01/01/1979 - "Dermabrasion in Darier's disease." 07/01/1992 - "Dermabrasion of Hailey-Hailey disease and Darier's disease." 04/01/1976 - "A case of severe cornifying Darier disease (keratosis follicularis) was successfully treated by deep dermal excision of diseased skin and subsequent dermabrasion, resulting in a remission lasting more than four years to date" Order ALL the reference details at left...
2.	Photochemotherapy (Photodynamic Therapy) 08/01/2006 - "Photodynamic therapy in a patient with Darier's disease." 09/01/2003 - "Treatment of Darier's disease with photodynamic therapy." 09/01/2003 - "OBJECTIVES: To evaluate the efficacy of photodynamic therapy in selected patients with Darier's disease (keratosis follicularis)" 09/01/2003 - "CONCLUSIONS: Photodynamic therapy can be viewed as a potential adjunctive modality for Darier's disease but should not be considered as a substitute for retinoids in patients who require systemic treatment." 08/01/1982 - "Dyskeratosis follicularis vegetans (Darier disease)--therapy with the aromatic retinoid RO 10-9359 (Tigason) in combination with systemic photochemotherapy (RePUVA)]" Order ALL the reference details at left...
3.	Solid-State Lasers 04/01/1999 - "Efficacy of erbium:YAG laser ablation in Darier disease and Hailey-Hailey disease." Order ALL the reference details at left...
4.	Gas Lasers 10/01/2008 - "Carbon dioxide laser ablation and adjunctive destruction for darier-white disease (keratosis follicularis)." 11/01/1990 - "We suggest carbon dioxide laser vaporization for the treatment of chronic, localized, symptomatic plaques of Hailey-Hailey or Darier's disease, if medical therapy has been ineffective." 11/01/1990 - "Carbon dioxide laser vaporization of localized, recalcitrant intertriginous plaques was done in two patients with Hailey-Hailey disease and two patients with Darier's disease" 11/01/1990 - "Carbon dioxide laser vaporization of recalcitrant symptomatic plaques of Hailey-Hailey disease and Darier's disease." 04/01/1999 - "BACKGROUND: Among different surgical approaches, dermabrasion and carbon dioxide laser vaporization have been used to treat Hailey-Hailey disease (HHD) (familial benign chronic pemphigus) and Darier disease (DD) (keratosis follicularis), with various results" Order ALL the reference details at left...
5.	Dye Lasers 08/01/2008 - "Successful treatment of Darier disease with the flashlamp-pumped pulsed-dye laser." Order ALL the reference details at left...

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