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Darier Disease (Darier's Disease)

An autosomal dominantly inherited skin disorder characterized by warty malodorous papules that coalesce into plaques. It is caused by mutations in the ATP2A2 gene encoding SERCA2 protein, one of the SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES. The condition is similar, clinically and histologically, to BENIGN FAMILIAL PEMPHIGUS, another autosomal dominant skin disorder. Both diseases have defective calcium pumps (CALCIUM-TRANSPORTING ATPASES) and unstable desmosomal adhesion junctions (DESMOSOMES) between KERATINOCYTES.
Also Known As:
Darier's Disease; Acantholytic Dyskeratotic Epidermal Nevi; Acantholytic Dyskeratotic Epidermal Nevus; Acrokeratosis Verruciformis; Hopf Disease; Darier White Disease; Darier-White Diseases; Dariers Disease; Disease, Darier; Disease, Darier's; Disease, Darier-White; Disease, Hopf; Diseases, Darier-White; Diseases, Hopf; Hopf Acrokeratosis Verruciformis; Hopf Diseases; Verruciformis, Acrokeratosis; Acrokeratosis Verruciformis of Hopf; Darier-White Disease; Keratosis Follicularis
Networked: 319 relevant articles (28 outcomes, 25 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Darier Disease (Darier's Disease)
2. Benign Familial Pemphigus (Hailey Hailey Disease)
3. Psoriasis (Pustulosis Palmaris et Plantaris)
4. Hidradenitis Suppurativa
5. Lamellar Ichthyosis (Harlequin Ichthyosis)

Experts

1. Hovnanian, Alain: 8 articles (07/2014 - 09/2003)
2. Hovnanian, A: 5 articles (01/2007 - 09/2000)
3. Munro, C S: 4 articles (09/2013 - 11/2001)
4. Shimizu, H: 4 articles (04/2004 - 04/2000)
5. Burge, S: 4 articles (02/2004 - 09/2000)
6. Ikeda, S: 3 articles (05/2012 - 01/2000)
7. Ogawa, H: 3 articles (05/2012 - 01/2000)
8. Burge, S M: 3 articles (09/2010 - 05/2004)
9. Tavadia, S: 3 articles (09/2010 - 11/2001)
10. Craddock, N: 3 articles (09/2010 - 01/2001)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Darier Disease:
1. EtretinateFDA Link
2. Tretinoin (Retinoic Acid)FDA LinkGeneric
3. AcitretinFDA Link
4. Vitamin A (Retinol)FDA LinkGeneric
5. Isotretinoin (Accutane)FDA LinkGeneric
6. RetinoidsIBA
7. tazarotene (Tazorac)FDA Link
8. alitretinoinFDA Link
9. adapalene (Differin)FDA LinkGeneric
10. Cyclosporine (Ciclosporin)FDA LinkGeneric

Therapies and Procedures

1. Photochemotherapy (Photodynamic Therapy)
2. Radiotherapy
3. Dermabrasion
4. Solid-State Lasers
5. Induced Hyperthermia (Thermotherapy)