Infectious Keratoconjunctivitis

Infectious diseases of cattle, sheep, and goats, characterized by blepharospasm, lacrimation, conjunctivitis, and varying degrees of corneal opacity and ulceration. In cattle the causative agent is MORAXELLA (MORAXELLA) BOVIS; in sheep, MYCOPLASMA; RICKETTSIA; CHLAMYDIA; or ACHOLEPLASMA; in goats, RICKETTSIA.

Also Known As:

Networked: 18 relevant articles (0 outcomes, 2 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Herpetic Keratitis
2.	Eye Infections
3.	Inflammation (Inflammations)
4.	Infections
5.	Conjunctivitis

Experts

1.	Frey, Joachim: 3 articles (01/2017 - 01/2003)
2.	Frey, J: 2 articles (08/2003 - 03/2001)
3.	Brennan, Marnie: 1 article (01/2021)
4.	Page, Phillipa: 1 article (01/2021)
5.	Hagström, Åsa: 1 article (01/2019)
6.	Jinnerot, Tomas: 1 article (01/2019)
7.	Leijon, Mikael: 1 article (01/2019)
8.	Rockström, Ulrika K: 1 article (01/2019)
9.	Sánchez Romano, Javier: 1 article (01/2019)
10.	Tryland, Morten: 1 article (01/2019)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Infectious Keratoconjunctivitis:

1.	CopperIBA 06/01/2013 - "Our previous studies in copper-deficient bovines have shown increased susceptibility to infectious keratoconjunctivitis, an ocular disease caused by Moraxella bovis. " 06/01/2013 - "Other components of local and systemic ocular defense mechanisms that could explain the increased susceptibility to infectious keratoconjunctivitis observed in copper-deficient bovines should be investigated." 05/01/2016 - "Copper (Cu) deficiency increases occurrence of certain infectious diseases in animals, including infectious keratoconjunctivitis in bovines, a bacterial ocular inflammation caused by Moraxella bovis. "
2.	Matrix Metalloproteinases (MMPs)IBA 04/01/2023 - "This study aimed to examine the effect of PRP on re-epithelization, corneal tissue, clinical signs, and matrix metalloproteinase (MMP) expression in sheep with infectious keratoconjunctivitis. "
3.	Oxytetracycline (Terramycin)FDA Link 01/01/2021 - "Do macrolides resolve clinical signs in sheep with infectious keratoconjunctivitis more rapidly than oxytetracycline?" 06/01/2015 - "Thirty-two strains of Moraxella spp. isolated from cattle and sheep with infectious keratoconjunctivitis were tested via broth microdilution method to determine their susceptibility to ampicillin, cefoperazone, ceftiofur, cloxacillin, enrofloxacin, florfenicol, gentamicin, neomycin, oxytetracycline and penicillin. "
4.	florfenicolIBA 02/01/2013 - "To measure florfenicol concentrations in ovine tear fluid after IM and SC administration and determine minimum inhibitory concentrations (MICs) of florfenicol against field isolates of Mycoplasma organisms potentially involved in infectious keratoconjunctivitis. " 02/01/2013 - "Florfenicol concentrations in ovine tear fluid following intramuscular and subcutaneous administration and comparison with the minimum inhibitory concentrations against mycoplasmal strains potentially involved in infectious keratoconjunctivitis." 06/01/2015 - "Thirty-two strains of Moraxella spp. isolated from cattle and sheep with infectious keratoconjunctivitis were tested via broth microdilution method to determine their susceptibility to ampicillin, cefoperazone, ceftiofur, cloxacillin, enrofloxacin, florfenicol, gentamicin, neomycin, oxytetracycline and penicillin. "
5.	Metalloproteases (Metalloproteinases)IBA 04/01/2023 - "Effects of platelet-rich plasma on corneal re-epithelization and metalloproteinase expression in the cornea of sheep with experimentally-induced infectious keratoconjunctivitis."
6.	MacrolidesIBA 01/01/2021 - "Do macrolides resolve clinical signs in sheep with infectious keratoconjunctivitis more rapidly than oxytetracycline?"
7.	SilverIBA 04/01/2006 - "An infectious keratoconjunctivitis (IKC) epizootic in bighorn sheep (Ovis canadensis) occurred in the Silver Bell Mountains, Arizona, USA, from 1 December 2003 to 31 March 2004. " 04/01/2006 - "Infectious keratoconjunctivitis in bighorn sheep, Silver Bell Mountains, Arizona, USA."
8.	Serine (L-Serine)FDA Link 01/01/2003 - "A serine-rich membrane protein named LppS from Mycoplasma conjunctivae, the aetiological agent of infectious keratoconjunctivitis (IKC) of domestic and wild Caprinae, was characterized. "
9.	16S Ribosomal RNAIBA 04/01/1999 - "Detection and identification of Mycoplasma conjunctivae in infectious keratoconjunctivitis by PCR based on the 16S rRNA gene."
10.	Penicillins (Penicillin)FDA Link 06/01/2015 - "Thirty-two strains of Moraxella spp. isolated from cattle and sheep with infectious keratoconjunctivitis were tested via broth microdilution method to determine their susceptibility to ampicillin, cefoperazone, ceftiofur, cloxacillin, enrofloxacin, florfenicol, gentamicin, neomycin, oxytetracycline and penicillin. "

Therapies and Procedures

1.	Therapeutics 12/15/1969 - "[Clinical picture, course and therapy of infectious keratoconjunctivitis caused by Rickettsiae and Moraxellae in a large calve stock]." 11/01/2006 - "Feline herpetic keratitis (infectious keratoconjunctivitis), an infection of the conjunctiva and cornea that is common in cats, involves a three-pronged treatment approach: (1)antiviral therapy, (2)immunomodulatory therapy, and (3)antibacterial therapy. "
2.	Immunomodulation 11/01/2006 - "Feline herpetic keratitis (infectious keratoconjunctivitis), an infection of the conjunctiva and cornea that is common in cats, involves a three-pronged treatment approach: (1)antiviral therapy, (2)immunomodulatory therapy, and (3)antibacterial therapy. "
3.	Transcutaneous Electric Nerve Stimulation (TENS) 01/01/2019 - "Infectious keratoconjunctivitis (IKC), the most common ocular disease in ruminants worldwide, has affected semi-domesticated Eurasian reindeer (Rangifer tarandus tarandus) for over 100 years, both as individual cases and in outbreaks affecting tens to hundreds of animals. "