|1.||Sharma, Namrata: 28 articles (03/2015 - 07/2002)|
|2.||Vajpayee, Rasik B: 26 articles (11/2015 - 05/2002)|
|3.||Pearlman, Eric: 24 articles (01/2016 - 03/2002)|
|4.||Lietman, Thomas M: 24 articles (08/2014 - 04/2003)|
|5.||Wilhelmus, Kirk R: 23 articles (01/2015 - 05/2002)|
|6.||Lalitha, Prajna: 22 articles (01/2015 - 11/2004)|
|7.||Acharya, Nisha R: 22 articles (08/2014 - 07/2006)|
|8.||Sharma, Savitri: 21 articles (11/2015 - 07/2002)|
|9.||Garg, Prashant: 21 articles (09/2015 - 08/2002)|
|10.||McLeod, Stephen D: 21 articles (08/2014 - 03/2003)|
|1.||Ciprofloxacin (Cipro)FDA LinkGeneric
10/01/1991 - "A multicenter, prospective clinical study of 148 culture-proven cases of bacterial keratitis, treated with ciprofloxacin 0.3% ophthalmic solution, compared its clinical and antibacterial efficacy with the standard therapy regimen of each investigator. "
04/01/2009 - "In this study, except for the Streptococcus species, ciprofloxacin was effective against the species responsible for severe bacterial keratitis."
01/01/2015 - "Ciprofloxacin (CIP) was effective in treating bacterial keratitis. "
02/01/2003 - "Ciprofloxacin therapy can be effective in the treatment of pneumococcal keratitis."
09/15/1992 - "Ciprofloxacin, a new broad-spectrum antibiotic effective against a variety of gram-positive and gram-negative bacteria, has recently become available in topical ophthalmic solution (3 mg/ml) for the treatment of bacterial keratitis. "
|2.||voriconazole (Vfend)FDA LinkGeneric
06/01/2014 - "To demonstrate that ultraviolet-A (UV-A) and voriconazole combination therapy is more effective than voriconazole single treatment for fungal keratitis. "
07/01/2015 - "Voriconazole spreads well in the eye and is effective in the cure of fungal keratitis including those caused by Alternaria."
04/01/2012 - "Intracameral and topical voriconazole may be effective against deep fungal keratitis presenting with endoexudates."
01/01/2012 - "Voriconazole was effective in treating this refractory keratitis."
06/01/2009 - "The voriconazole 1% eye drop used alone is a promising, cost-effective, safe option for managing fungal keratitis, even that caused by S. "
|3.||Ophthalmic Solutions (Eye Drops)IBA
01/01/2010 - "Despite existing evidence to suggest that the eye drops are effective in the treatment of fungal keratitis, more studies are needed, especially in relation to using the eye drops as first-line and stand-alone treatment, preparation of higher concentrations, and optimal dosing frequency."
03/01/2008 - "The AS eye drops application improved significantly the values of the Schirmer test, detritus and superficial punctate keratitis as well. "
05/01/1999 - "The findings in this pilot study suggest that HSV stromal keratitis can be treated successfully with CsA eyedrops, especially in non-necrotizing disease. "
02/01/1987 - "These results indicate that 2'NDG may be therapeutically effective in treatment of herpes keratitis, and further suggest that for use as eye drops or in an ophthalmic insert, 2'NDG may be effective even if applied once per day."
10/01/2011 - "The efficacy of 0.1% MCFG eye-drops appears to be comparable with that of 0.2% FCZ eye-drops in the treatment of Candida fungal keratitis."
|4.||Acyclovir (Aciclovir)FDA LinkGeneric
04/01/1988 - "All 20 patients with active stromal keratitis or keratouveitis improved on acyclovir, all four patients using acyclovir postoperatively were disease-free while on the drug, but only two of the four patients using acyclovir to assist tapering topical medications were successful. "
02/01/1983 - "A combination of acyclovir and dilute steroid drops is effective in the management of disciform keratitis."
08/27/2005 - "This study aimed to evaluate the efficacy of topical ophthalmic aciclovir applied five times daily as a treatment for feline herpesvirus type 1 (FHV-1) keratitis in a group of cats in a first-opinion practice setting. "
09/01/2007 - "Prophylactic oral acyclovir use after PK for HSV keratitis is associated with decreased episodes of rejection and improved graft survival."
08/01/1987 - "Efficacy of (E)-5-(2-bromovinyl)- and 5-vinyl-1-beta-D-arabinofuranosyluracil against acute herpes simplex virus keratitis and the establishment of latency: comparison with acyclovir and bromovinyldeoxyuridine."
|5.||Natamycin (Pimaricin)FDA Link
03/01/2004 - "Fungal keratitis caused by Scopulariopsis brevicaulis treated successfully with natamycin."
12/01/2009 - "Treatment with topical natamycin was effective against Epidermophyton keratitis."
11/01/2015 - "Specifically, the smaller the natamycin inhibition zone, the lower the probability that the fungal keratitis had been eliminated."
09/01/2014 - "To compare the efficacy of combined intrastromal injection and topical natamycin 5% to standard topical therapy alone in an experimental rabbit model of Fusarium keratitis. "
09/01/2014 - "Safety and efficacy of intrastromal injection of 5% natamycin in experimental fusarium keratitis."
01/01/1992 - "Treatment of keratitis with antibiotic-impregnated collagen shields may reduce the need for very frequent application of topical drops, but may be more effective with topical drop supplementation to increase the amount of drug available over the course of therapy."
01/01/2013 - "Collagen cross linking (CXL) of the cornea has been developed recently as a new treatment for multidrug-resistant infectious keratitis. "
01/01/2016 - "To assess the efficacy of corneal collagen cross-linking (CXL) in the management of infectious keratitis. "
12/01/2014 - "To report the use of accelerated photoactivated chromophore for keratitis-corneal collagen cross-linking (PACK-CXL) as a first-line treatment in a patient with an atypical fungal keratitis. "
12/01/2014 - "Antibacterial efficacy of accelerated photoactivated chromophore for keratitis-corneal collagen cross-linking (PACK-CXL)."
|7.||Anti-Bacterial Agents (Antibiotics)IBA
04/01/1987 - "chelonei keratitis and aggressive therapy with appropriate antibiotics can lead to a complete cure, with excellent functional results."
01/01/2013 - "Keratitis was observed in 4 patients (10%) who were treated successfully with topical antibiotics. "
08/01/1997 - "The keratitis was treated successfully with combination fortified topical antibiotics without loss of vision. "
08/01/2009 - "With advances in the understanding of its pathogenesis, laboratory investigations like immunohistochemistry, fluorescent microscopy, enzyme immunoassays and molecular biology, and the availability of fourth generation antibiotics, the overall visual outcome in bacterial keratitis has improved with time. "
08/01/1994 - "In experimentally induced bacterial keratitis, transcorneal iontophoresis of antibacterial agents is superior to topically administered ocular drops for reducing the numbers of bacteria in the cornea. "
|8.||Adrenal Cortex Hormones (Corticosteroids)IBA
06/01/2014 - "Patients with non-Nocardia keratitis and those having no topical antibiotic use before the SCUT enrollment showed significant improvement in best spectacle-corrected visual acuity at 3 months if corticosteroids were administered earlier rather than later. "
02/01/2000 - "It is beneficial in treating infectious epithelial keratitis and prophylactically either while treating with topical corticosteroids for immune stromal keratitis or for preventing recurrent infectious epithelial keratitis."
08/01/1981 - "The safety and efficacy of corticosteroids in microbial keratitis have not been established."
03/01/2002 - "All 13 eyes responded favorably to the combination of intensive topical and oral corticosteroids and had a BCVA of 20/20 after the keratitis resolved. "
05/01/1999 - "These 6 patients with keratitis improved only with combined CsA/corticosteroids. "
|9.||Ofloxacin (Levofloxacin)FDA LinkGeneric
06/01/2014 - "Furthermore, treatment with OH-CATH30, alone or in combination with levofloxacin, significantly improved the clinical outcomes of rabbit keratitis induced by antibiotic-resistant P. "
06/01/2010 - "Levofloxacin 1.5% was effective for reducing SA and PA in the rabbit keratitis models regardless of in vitro resistance."
10/01/2002 - "Ofloxacin, VCM, and ABK are effective in the treatment of MRS keratitis. "
09/01/2010 - "Novel mucoadhesive polysaccharide isolated from Bletilla striata improves the intraocular penetration and efficacy of levofloxacin in the topical treatment of experimental bacterial keratitis."
12/01/2015 - "To compare the efficacy of topical 1.5% and 0.5% levofloxacin (LVFX) for the treatment of multidrug-resistant Pseudomonas aeruginosa (MDRP) keratitis in rabbits. "
|10.||Tobramycin (Nebcin)FDA LinkGeneric
01/01/1978 - "We evaluated several therapeutic modifications in an attempt to improve efficacy of topical therapy with tobramycin of experimental Pseudomonas keratitis in guinea pigs. "
05/01/1987 - "Finally, a Pseudomonas aeruginosa keratitis model in the rat demonstrates the antibiotic efficacy of topical tobramycin treatment over untreated controls (P less than 0.00001), and a progressively enhanced efficacy with increasing tobramycin concentrations is suggested. "
05/01/1979 - "We determined the efficacy of tobramycin administered by topical, intramuscular, and subconjunctival routes in guinea pigs and rabbits with experimental Pseudomonas keratitis. "
03/01/2015 - "Despite bacterial colonization in 9 CLs, no clinical signs of infectious keratitis were found in any of the patients with prophylactic topical tobramycin 3%. "
07/01/2001 - "The effectiveness of tobramycin and Ocuflox in a prophylaxis model of Staphylococcus keratitis."
06/01/2006 - "A combined acanthamoeba-stenotrophomonas keratitis, which is resistant to medical therapy, can be treated successfully with a conjunctival flap followed by a penetrating keratoplasty."
06/01/2006 - "Penetrating keratoplasty for viral keratitis may achieve good results with long term antiviral treatment. "
05/01/2015 - "Candida glabrata interface keratitis can occur early after DALK, which can only be effectively treated with penetrating keratoplasty. "
03/01/2010 - "To study the use of penetrating keratoplasty for the treatment of severe fungal keratitis that could not be cured by antifungal medication. "
09/01/2001 - "To study the use of penetrating keratoplasty (PKP) for the treatment of severe fungal keratitis that could not be cured by antifungal medication. "
04/01/1995 - "In the mouse model of HSV-1-induced keratitis and encephalopathy, topical administration of OC-I to the mouse cornea produced a significant decrease in virus production in the cornea (mean virus yields: 3.11 log10 PFU in the treated group and 4.37 log10 PFU in the control group) and significant improvement in survival rates (P = 0.01). "
09/01/2004 - "Standard treatment of bacterial keratitis includes topical administration of concentrated antibiotic solutions repeated at frequent intervals in order to reach sufficiently high drug levels in the corneal tissue to inhibit bacterial growth. "
01/01/2001 - "Therapeutic concentrations are achieved in the cornea after topical administration so that the fluoroqinolones have largely replaced combination therapy for the treatment of bacterial keratitis. "
10/01/1990 - "Topical administration of AC-SOD to the LPS-treated cornea markedly inhibited the infiltration of PMNs and suppressed the occurrence of keratitis. "
02/01/2000 - "Topical administration of purified GSH was able to reduce the virus titre in corneal tissue and, at the same time, was effective in reducing the severity and progression of keratitis and conjunctivitis. "
|3.||Laser In Situ Keratomileusis (LASIK)
10/01/2014 - "Post-LASIK interface fungal filamentous keratitis can present early and gives good outcomes with early microbiological diagnosis and appropriate management. "
07/01/2011 - "Improved understanding of the risk factor, different causes, along with a high degree of suspicion on initial presentation is crucial in order to provide the appropriate management in LASIK-associated infectious keratitis."
06/01/2007 - "Autologous platelet-rich plasma was effective in the treatment of patients with ocular surface syndrome following LASIK, with symptoms generally relieved and a positive effect on punctate keratitis."
06/01/2006 - "Recalcitrant post-LASIK Mycobacterium chelonae keratitis eradicated after the use of fourth-generation fluoroquinolone."
07/01/2011 - "Many recent studies of post-LASIK infectious keratitis show the predominance of atypical mycobacteria and Gram-positive cocci and the growing number of other rare pathogens. "
|4.||Transplantation (Transplant Recipients)
09/01/2014 - "In patients with viral keratitis and central neovascularization, a significant reduction in transplantation need was achieved (P = 0.048). "
01/01/2008 - "To study, with the use of an animal model, the efficacy of amniotic membrane (AM) transplantation as adjunctive treatment in corneal healing after bacterial keratitis. "
06/01/2012 - "To evaluate the efficacy of amniotic membrane transplantation (AMT) to improve the outcomes of acute Pseudomonas keratitis as compared with a control group. "
09/01/2007 - "Necrotizing herpetic stromal keratitis (HSK) in mice rapidly improved after amniotic membrane transplantation (AMT). "
06/01/2012 - "A controlled study of amniotic membrane transplantation for acute Pseudomonas keratitis."
|5.||Corneal Transplantation (Keratoplasty)
11/20/2012 - "To explore the clinical safety and efficacy of deep lamellar keratoplasty for corneal macula after viral keratitis. "
09/01/2014 - "These researches were concentrated in the following fields: Clinical and basic research in infectious keratitis; clinical application of modern corneal surgeries and technology; tissue engineering corneal material development; prevention and treatment of immune rejection after corneal transplantation, et al. These studies represented the level of our national cornea and ocular surface specialists in the international cornea and OSD field and have become the landmark study of our specialists. "
01/01/2014 - "The purpose of this study was to describe the clinical characteristics of fungal keratitis caused by Candida albicans in an eye after Descemet stripping automated endothelial keratoplasty (DSAEK). "
05/01/2012 - "The objective of this study was to report 2 cases of interface fungal keratitis in 2 separate patients following Descemet stripping automated endothelial keratoplasty (DSAEK) with tissue harvested from the same donor. "
05/01/2010 - "To study the risk factors, clinical features, and treatment of recurrent fungal keratitis after corneal transplantation. "