Chlordecone (Kepone)

A highly chlorinated polycyclic hydrocarbon insecticide whose large number of chlorine atoms makes it resistant to degradation. It has been shown to be toxic to mammals and causes abnormal cellular changes in laboratory animals.

Also Known As:

Networked: 114 relevant articles (1 outcomes, 19 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Thomé, Jean-Pierre: 9 articles (01/2022 - 03/2013)
2.	Cordier, Sylvaine: 8 articles (01/2022 - 07/2010)
3.	Multigner, Luc: 8 articles (01/2022 - 07/2010)
4.	Kadhel, Philippe: 7 articles (01/2022 - 03/2013)
5.	Monfort, Christine: 7 articles (01/2022 - 03/2013)
6.	Rouget, Florence: 7 articles (01/2022 - 03/2013)
7.	Costet, Nathalie: 4 articles (01/2022 - 03/2014)
8.	Roberts, Stephen M: 3 articles (09/2007 - 03/2005)
9.	Sobel, Eric S: 3 articles (09/2007 - 03/2005)
10.	Michineau, Léah: 2 articles (01/2022 - 01/2022)

Related Diseases

1.	Tremor (Tremors) 12/15/2018 - "Amplified tremors presented in the MHV3- chlordecone mouse model had led us to study the expression of specific genes in the brain. " 01/01/1986 - "Most such studies, however, have used relatively high doses of chlordecone so it has been difficult to determine if the serotoninergic change preceded or resulted from the tremor. " 01/01/1985 - "Drugs with known pharmacological effects were used to study the possible mechanism of chlordecone-induced tremor. " 01/01/1985 - "Studies on the mechanism of chlordecone-induced tremor in rats." 09/30/1983 - "Studies on the possible sites of chlordecone-induced tremor in rats."
2.	Neoplasms (Cancer) 01/01/1979 - "Kepone induced malignant tumors in the liver of rats and mice in the NCI studies and in the liver in rats in the Medical College of Virginia study. " 09/01/1978 - "Kepone induced malignant tumors in the liver of rats and mice in the National Cancer Institute studies and in the liver in rats in the Medical College of Virginia study. " 12/01/2016 - "We derive ERFs for 3 possible effects at chronic low chlordecone dose: cancers, developmental impairment, and hepatotoxicity. " 08/01/2008 - "[Chlordecone and cancer in French-West Indies]." 06/01/1989 - "In contrast, none of comparably treated males had malignant liver tumors, even after 44 weeks of 'promotion' with chlordecone. "
3.	Body Weight (Weight, Body) 01/01/2022 - "Globally, we found little evidence of an association between chlordecone exposure during the critical in utero or childhood periods of development and altered body-weight homeostasis in childhood. " 01/01/1992 - "In addition, chlordecone treatment inhibited food intake within 2 hr. Consequently, these results suggest that chlordecone suppresses food intake which in turn produces the decline in body weight." 01/01/1992 - "Effects of chlordecone on food intake and body weight in the male rat." 01/01/1991 - "Chlordecone also rapidly suppressed food intake and led to a significant decline in body weight; these nutritional factors could have contributed to the disrupted estrous cycle. " 01/01/1987 - "Male Sprague-Dawley rats were pretreated with 15 mg chlordecone per kilogram body weight (BW) intragastrically or with vehicle. "
4.	Birth Weight (Birth Weights) 11/01/2016 - "After stratification by GWG, we found a significant U-shaped association between birth weight and chlordecone exposure, within the upper quartiles of GWG or excessive GWG. " 11/01/2016 - "Overall chlordecone in cord blood was not associated with birth weight, but we found an interaction between chlordecone exposure with GWG and adherence to GWG recommendations. " 11/01/2016 - "Birth weight was analyzed relative to cord blood chlordecone levels using linear and non-linear regression models. " 11/01/2016 - "Prenatal exposure to chlordecone, gestational weight gain, and birth weight in a Guadeloupean birth cohort." 10/01/1982 - "Exposure to chlordecone had no effect on maternal weight gains after gestation nor did it affect birth weights, litter sizes, or sex ratio of the litters. "
5.	Malnutrition (Nutritional Deficiencies) 01/01/1993 - "Effect of Chlordecone (Cd) and malnutrition on total body and spleen weights, and plaque forming cells (PFC) were studied. " 01/01/1993 - "Effects of chlordecone and malnutrition on immune response in rats." 02/10/2016 - "After 21 days of depuration in undernutrition, AT PCB 153 and 180 concentrations were increased concomitantly with a decrease in adipocyte volume, whereas AT chlordecone concentration was not different from that observed at the end of the well-fed contamination period. " 02/10/2016 - "The current study aimed to determine in nonlactating ewes whether polychlorinated biphenyls (PCBs) and chlordecone are released from AT to blood along with lipids during body fat mobilization achieved through β-agonist challenges or undernutrition. "

Related Drugs and Biologics

1.	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)
2.	Acetylcholine (Acetylcholine Chloride)
3.	Mirex
4.	Insecticides
5.	Pesticides
6.	DDT
7.	Serotonin (5 Hydroxytryptamine)
8.	Endosulfan
9.	Dieldrin
10.	Transaminases (Aminotransferases)

Related Therapies and Procedures

1.	Injections
2.	Oral Administration
3.	Ovariectomy (Oophorectomy)
4.	Induced Hypothermia
5.	Hepatectomy